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1 2 3 O. D. Wiestler , U. Schlege1 , andJ. Schramm lInstitut flir
Neuropathologie, Universitatskliniken Bonn, Sigmund-Freud-Str. 25,
53127 Bonn, Germany 2Neurologische Universitatsklinik,
Sigmund-Freud-Str. 25, 53127 Bonn, Germany 3Neurochirurgische
Universitatsklinik, Sigmund-Freud-Str. 25,53127 Bonn, Germany In
contrast to various other neoplastic disorders, there has still
been no dramatic progress in the treatment of gliomas. Modem
microsurgical and imaging techniques have made more tumors
surgically accessible and have allowed a more extensive surgical
resection. However, these new developments have not improved the
clinical outcome. Recently, molecular biological studies on genes
and genetic loci affected in tumors of the nervous system have
yielded significant new insights into pathoge- netic machanisms.
Many neuro-oncologists are therefore looking forward to transla-
ting molecular genetic findings into novel diagnostic and
therapeutic strategies for the management of these devastating
neoplasms. We have produced this volume with the intention of
highlighting major developments in both molecular and clinical
neuro-oncology and of stimulating the communication and cooperation
between these two fields. Two major families of growth-controlling
genes have emerged from the past decade of intense research on the
molecular genetics of tumors: oncogenes and tumor suppressor genes.
Oncogenes are characterized by their potential to stimulate the
growth of susceptible cells whereas tumor suppressor genes share a
growth-inhibi- ting property. A stringently controlled interplay
between these two regulatory me- chanisms is required to maintain a
stable composition of tissues.
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