To make innovations work commercially among the target group requires institutional approach that can anticipate and predict users’ urgent needs through participation. Conversely, to make innovations work technically requires a pile of junk and good imagination according to Thomas Edison. Biotechnology no doubt is a significant innovation that can enable farmers in developing countries increase productivity and manage their products. Nevertheless, biotech application is surrounded with many controversial debates. These controversies have affected its perception among farmers and consumers alike. Using a mixed method approach, empirical data were gathered from farmers and extension agents in six geopolitical divisions of Nigeria to determine factors capable of ensuring sustainable biotech adoption. Results revealed that the probability of biotech adoption is dependent on a cause and effect relationship.