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This is the story of steroid-protein interactions as one
investigator sees it. Following the general concept of this
monograph series, it emphasizes the results and interpretations
obtained in the author's laboratory, and is therefore a subjective
account. Recognizing, how ever, that the discussion of the subject
would be incomplete if the material were limited to one scientist's
work, the essential achieve ments of other investigators have been
incorporated. An effort has thus been made to give a balanced
presentation and to enable the reader to see in perspective the
varied facets of the interactions between steroids and proteins.
Since this is the first comprehensive treatment of the topic, it
seems appropriate to go to the roots, and try to find out how it
all started. The first chapters, therefore, take the reader to the
laboratories of those who very early conceived the significance of
the attachment of dyes, drugs, and other conspicuous molecules to
those colloids called proteins. The discovery of the steroid
hormones set the stage for meaningful investigation of their
interaction with proteins of various origins and functions - a
process which is continuing today with increasing vigor."
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