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This second edition further develops the principles of applying
kinetic principles to drug metabolizing enzymes and transporters.
Chapters are divided into six sections detailing fundamental
principles of enzyme kinetics, enzyme and transporter structures,
highlighting specific oxidative and conjugative drug metabolizing
enzymes and drug transporters, modeling approaches for drug
metabolizing enzymes and transporters, understanding of variability
both experimental and interindividual (pharmacogenomic), and
expanded case studies that provide real life examples of applying
these principles. Written in the highly successful Methods in
Molecular Biology series format, chapters include introductions to
their respective topics, in some cases step-by-step instructions
with readily reproducible laboratory protocols, and tips on
troubleshooting and avoiding known pitfalls with extensive cross
referencing to assist in learning. Authoritative and fully updated,
Enzyme Kinetics in Drug Metabolism: Fundamentals and Applications,
Second Edition serves as a practical teaching tool for novice and
advanced scientists interested in the fundamental concepts.
Drug metabolism and transport are very important facets within the
discipline of pharmaceutical sciences, with enzyme kinetic concepts
utilized regularly in characterizing and modeling the disposition
and elimination of drugs. Enzyme Kinetics in Drug Metabolism:
Fundamentals and Applications focuses on very practical aspects of
applying kinetic principles to drug metabolizing enzymes and
transporters. Divided into five convenient sections, topics include
the fundamental principles of enzyme kinetics, the kinetics of
oxidative and conjugative drug metabolizing enzymes and drug
transporters, modeling approaches for both drug metabolizing
enzymes and transporters including novel systems biology
approaches, understanding of variability both experimental and
interindividual (pharmacogenomic), and case studies that provide
real life examples of applying these principles. Written in the
successful Methods in Molecular Biology series format, chapters
include introductions to their respective topics especially
suitable for the novice, in some cases step-by-step, readily
reproducible protocols, and insights to help with troubleshooting
and avoiding known pitfalls with extensive cross referencing to
assist in learning. Authoritative and easily accessible, Enzyme
Kinetics in Drug Metabolism: Fundamentals and Applications serves
as a very practical teaching tool for novice, non-mathematically
trained scientists interested in these fundamental concepts and as
an aid for their supervisors in teaching these principles.
Drug metabolism and transport are very important facets within the
discipline of pharmaceutical sciences, with enzyme kinetic concepts
utilized regularly in characterizing and modeling the disposition
and elimination of drugs. Enzyme Kinetics in Drug Metabolism:
Fundamentals and Applications focuses on very practical aspects of
applying kinetic principles to drug metabolizing enzymes and
transporters. Divided into five convenient sections, topics include
the fundamental principles of enzyme kinetics, the kinetics of
oxidative and conjugative drug metabolizing enzymes and drug
transporters, modeling approaches for both drug metabolizing
enzymes and transporters including novel systems biology
approaches, understanding of variability both experimental and
interindividual (pharmacogenomic), and case studies that provide
real life examples of applying these principles. Written in the
successful Methods in Molecular Biology series format, chapters
include introductions to their respective topics especially
suitable for the novice, in some cases step-by-step, readily
reproducible protocols, and insights to help with troubleshooting
and avoiding known pitfalls with extensive cross referencing to
assist in learning. Authoritative and easily accessible, Enzyme
Kinetics in Drug Metabolism: Fundamentals and Applications serves
as a very practical teaching tool for novice, non-mathematically
trained scientists interested in these fundamental concepts and as
an aid for their supervisors in teaching these principles.
This second edition further develops the principles of applying
kinetic principles to drug metabolizing enzymes and transporters.
Chapters are divided into six sections detailing fundamental
principles of enzyme kinetics, enzyme and transporter structures,
highlighting specific oxidative and conjugative drug metabolizing
enzymes and drug transporters, modeling approaches for drug
metabolizing enzymes and transporters, understanding of variability
both experimental and interindividual (pharmacogenomic), and
expanded case studies that provide real life examples of applying
these principles. Written in the highly successful Methods in
Molecular Biology series format, chapters include introductions to
their respective topics, in some cases step-by-step instructions
with readily reproducible laboratory protocols, and tips on
troubleshooting and avoiding known pitfalls with extensive cross
referencing to assist in learning. Authoritative and fully updated,
Enzyme Kinetics in Drug Metabolism: Fundamentals and Applications,
Second Edition serves as a practical teaching tool for novice and
advanced scientists interested in the fundamental concepts.
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