The book aims to cover basic physiologic functions of melatonin, and its therapeutic applications in humans for a variety of clinically relevant disorders. This book contains chapters on the recent aspects of melatonin physiology, its receptors and their role in mitochondrial function, its immunomodulatory role and importance in seasonal dependent diseases, role in human reproduction, role in sleep, circadian rhythm and sleep disorders, role in neurologic disorders such as Parkinson's disease, Alzheimer's disease. Additionally, melatonin's therapeutic use in neurobehavioral disorders in children, migraine and tension headache is also covered in this book. Melatonin's antioxidant role in Duchenne's muscular dystrophy and in glaucoma have also been discussed in short chapters. Two major melatonin agonists, ramelteon and agomelatine are discussed extensively on their current clinical application and ongoing research. Two chapters on agomelatonin and its role in mood disorders, particularly depressive disorders, are an important feature of this book. The chapters are written by experts from the global academia recognized for their original research and published work in the field of melatonin science.

The book aims to cover basic physiologic functions of melatonin, and its therapeutic applications in humans for a variety of clinically relevant disorders. This book contains chapters on the recent aspects of melatonin physiology, its receptors and their role in mitochondrial function, its immunomodulatory role and importance in seasonal dependent diseases, role in human reproduction, role in sleep, circadian rhythm and sleep disorders, role in neurologic disorders such as Parkinson's disease, Alzheimer's disease. Additionally, melatonin's therapeutic use in neurobehavioral disorders in children, migraine and tension headache is also covered in this book. Melatonin's antioxidant role in Duchenne's muscular dystrophy and in glaucoma have also been discussed in short chapters. Two major melatonin agonists, ramelteon and agomelatine are discussed extensively on their current clinical application and ongoing research. Two chapters on agomelatonin and its role in mood disorders, particularly depressive disorders, are an important feature of this book. The chapters are written by experts from the global academia recognized for their original research and published work in the field of melatonin science.

the enterprise of today has changed wherever you sit in this new corporation Srinivasan gives us a practical and provocative guide for rethinking our business process calling us all to action around rapid development of our old, hierarchical structures into flexible customer centric competitive force . A must read for today s business leader. Mark Nunnelly, Executive Director, MassIT, Commonwealth of Massachusetts and Managing Director, Bain Capital Efficiency, agile, and analytics used to be the rage. Venkat Srinivasan explains in this provocative book why organizations can no longer afford to stop there. They need to move beyond to be intelligent. It isn t just theory. He s done it. Bharat Anand, Henry R. Byers Professor of Business Administration, Harvard Business School In the era of big data and automation, the book presents a cutting-edge approach to how enterprises should organize and function. Striking a practical balance between theory and practice, The Intelligent Enterprise in the Era of Big Data presents the enterprise architecture that identifies the power of the emerging technology environment. Beginning with an introduction to the key challenges that enterprises face, the book systematically outlines modern enterprise architecture through a detailed discussion of the inseparable elements of such architecture: efficiency, flexibility, and intelligence. This architecture enables rapid responses to market needs by sensing important developments in internal and external environments in real time. Illustrating all of these elements in an integrated fashion, The Intelligent Enterprise in the Era of Big Data also features: A detailed discussion on issues of time-to-market and flexibility with respect to enterprise application technology Novel analyses illustrated through extensive real-world case studies to help readers better understand the applicability of the architecture and concepts Various applications of natural language processing to real-world business transactions Practical approaches for designing and building intelligent enterprises The Intelligent Enterprise in the Era of Big Data is an appropriate reference for business executives, information technology professionals, data scientists, and management consultants. The book is also an excellent supplementary textbook for upper-undergraduate and graduate-level courses in business intelligence, data mining, big data, and business process automation. a compelling vision of the next generation of organization the intelligent enterprise which will leverage not just big data but also unstructured text and artificial intelligence to optimize internal processes in real time a must-read book for CEOs and CTOs in all industries. Ravi Ramamurti, D Amore-McKim Distinguished Professor of International Business and Strategy, and Director, Center for Emerging Markets, Northeastern University It is about the brave new world that narrows the gap between technology and business . The book has practical advice from a thoughtful practitioner. Intelligent automation will be a competitive strength in the future. Will your company be ready? Victor J. Menezes, Retired Senior Vice Chairman, Citigroup Venkat Srinivasan, PhD, is Chairman and Chief Executive Officer of RAGE Frameworks, Inc., which supports the creation of intelligent business process automation solutions and cognitive intelligence solutions for global corporations. He is an entrepreneur and holds several patents in the area of knowledge-based technology architectures. He is the author of two edited volumes and over 30 peer-reviewed publications. He has served as an associate professor in the College of Business Administration at Northeastern University.