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During the past few years, a considerable number of monographs on
bone tumors have been published. They are mainly restricted to bone
tumors as clinical-pathological entities, since their diagnosis,
more than that of other tumors, requires the interdisciplinary
cooperation between orthopedic specialist, radiologist, and
pathologist. However, investiga tions concerning the histogenesis
of bone tumors are rather limited, although they might be helpful
in explaining the unique morphological heterogeneity of tumors of
the skeletal system. Furthermore, the histo genetic approach in the
study of bone tumors may facilitate the inter pretation of the
advanced cytobiological methods available for improv ing
classification and diagnosis. Therefore, this volume presents
recent pathological advances in the biological characterization of
bone tumors. A major chapter deals with the differential diagnosis
of Ewing's sarcoma as regards its demarcation from the so-called
neuroectodermal tumor of bone. The analysis of the ground
substances in bone-forming tumors may be helpful for their
classification. Therefore the volume includes a chapter on the
biochemical and histochemical analysis of different osteosarcoma
types. Recently it has become clear that in addition to different
collagen types which are not specific for bone tissue, several
bone-specific proteins occur, one of which is osteonectin. Its
distribu tion is obviously important for the classification and
diagnosis of osteo blastic tumors. Proliferative behavior is of
major importance for the diagnosis of malignant tumors.
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