This is the very first book to deal with sex and gender differences in drug therapy - an increasingly recognized medical need. It starts with an overview on S/G in clinical syndromes and a documentation of the medical and socioeconomic damage caused by gender specific adverse drug effects. Part I covers S/G differences in pharmacokinetics. Researchers will be satisfied by the detailed discussion of the mechanisms of S/G differences in drug effects that represents cutting edge science and includes interaction of drugs with sex hormones, genomic and epigenetic mechanisms. It also covers S/G in drug development, in animal models and clinical development and S/G in drug prescriptions. Part II targets S/G differences in drug effects in cardiovascular, pulmonary, CNS, neuromuscular, neuropsychiatric and metabolic diseases, in cancer, inflammation, and rheumatic diseases, in bacterial and retroviral infections, thrombosis, embolism. New drugs will be discussed.

This is the very first book to deal with sex and gender differences in drug therapy - an increasingly recognized medical need. It starts with an overview on S/G in clinical syndromes and a documentation of the medical and socioeconomic damage caused by gender specific adverse drug effects. Part I covers S/G differences in pharmacokinetics. Researchers will be satisfied by the detailed discussion of the mechanisms of S/G differences in drug effects that represents cutting edge science and includes interaction of drugs with sex hormones, genomic and epigenetic mechanisms. It also covers S/G in drug development, in animal models and clinical development and S/G in drug prescriptions. Part II targets S/G differences in drug effects in cardiovascular, pulmonary, CNS, neuromuscular, neuropsychiatric and metabolic diseases, in cancer, inflammation, and rheumatic diseases, in bacterial and retroviral infections, thrombosis, embolism. New drugs will be discussed.

Das Buch ist ein praxisorientiertes Nachschlagewerk für alle Ärztinnen und Ärzte, die die komplizierten Zusammenhänge zwischen Geschlecht und Gesundheit verstehen wollen. Geschlechtsspezifische Konzepte werden für die Innere Medizin und die Neurologie praxisrelevant aufbereitet – als Information für Kliniker*innen in den internistischen Disziplinen und der Neurologie, daneben auch für Spezialist*innen, die sich mit Pharmakotherapie, Pathophysiologie und Genomik befassen. Die einzelnen Gebiete werden systematisch im Hinblick auf geschlechtsspezifische Unterschiede in Prävention, Klinik, Diagnose, interventioneller und pharmakologischer Therapie dargestellt.