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This is the very first book to deal with sex and gender differences
in drug therapy - an increasingly recognized medical need. It
starts with an overview on S/G in clinical syndromes and a
documentation of the medical and socioeconomic damage caused by
gender specific adverse drug effects. Part I covers S/G differences
in pharmacokinetics. Researchers will be satisfied by the detailed
discussion of the mechanisms of S/G differences in drug effects
that represents cutting edge science and includes interaction of
drugs with sex hormones, genomic and epigenetic mechanisms. It also
covers S/G in drug development, in animal models and clinical
development and S/G in drug prescriptions. Part II targets S/G
differences in drug effects in cardiovascular, pulmonary, CNS,
neuromuscular, neuropsychiatric and metabolic diseases, in cancer,
inflammation, and rheumatic diseases, in bacterial and retroviral
infections, thrombosis, embolism. New drugs will be discussed.
This is the very first book to deal with sex and gender differences
in drug therapy - an increasingly recognized medical need. It
starts with an overview on S/G in clinical syndromes and a
documentation of the medical and socioeconomic damage caused by
gender specific adverse drug effects. Part I covers S/G differences
in pharmacokinetics. Researchers will be satisfied by the detailed
discussion of the mechanisms of S/G differences in drug effects
that represents cutting edge science and includes interaction of
drugs with sex hormones, genomic and epigenetic mechanisms. It also
covers S/G in drug development, in animal models and clinical
development and S/G in drug prescriptions. Part II targets S/G
differences in drug effects in cardiovascular, pulmonary, CNS,
neuromuscular, neuropsychiatric and metabolic diseases, in cancer,
inflammation, and rheumatic diseases, in bacterial and retroviral
infections, thrombosis, embolism. New drugs will be discussed.
Das Buch ist ein praxisorientiertes Nachschlagewerk für alle
Ärztinnen und Ärzte, die die komplizierten Zusammenhänge
zwischen Geschlecht und Gesundheit verstehen wollen.
Geschlechtsspezifische Konzepte werden für die Innere Medizin und
die Neurologie praxisrelevant aufbereitet – als Information für
Kliniker*innen in den internistischen Disziplinen und der
Neurologie, daneben auch für Spezialist*innen, die sich mit
Pharmakotherapie, Pathophysiologie und Genomik befassen. Die
einzelnen Gebiete werden systematisch im Hinblick auf
geschlechtsspezifische Unterschiede in Prävention, Klinik,
Diagnose, interventioneller und pharmakologischer Therapie
dargestellt.
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