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Fluorine chemistry is an expanding area of research that is
attracting international interest, due to the impact of fluorine in
drug discovery and in clinical and molecular imaging (e.g. PET,
MRI). Many researchers and academics are entering this area of
research, while scientists in industrial and clinical environments
are also indirectly exposed to fluorine chemistry through the use
of fluorinated compounds for imaging.This book provides an overview
of the impact that fluorine has made in the life sciences. In the
first section, the emphasis is on how fluorine substitution of
amino acids, peptides, nucleobases and carbohydrates can provide
invaluable information at a molecular level. The following chapters
provide answers to the key questions posed on the importance of
fluorine in drug discovery and clinical applications. For examples,
the reader will discover how fluorine has found its place as a key
element improving drug efficacy, with reference to some of the
best-selling drugs on the market. Finally, a thorough review on the
design, synthesis and use of 18F-radiotracers for positron emission
tomography is provided, and this is complemented with a discussion
on how 19F NMR has advanced molecular and clinical imaging.
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