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The present investigation was designed with an aim to formulate
Chitosan (CH) films by cross-linking with Sodium citrate (Nacit),
Sodium tripolyphosphate (NaTPP) or Chondroitin sulphate (CS) that
shall be capable of simulating the in vitro permeation of model
polar drug, 5-Fluorouracil (5-FU) and non polar drug, Indomethacin
(INDO) across rat/rabbit or human epidermis. Optimization design
was employed to identify and optimize various process and
formulation variables significantly (p
Chitosan is the deacetylated form of chitin. Generally, the
substance becomes soluble in dilute acids when the degree of
deacetylation is more than 50%. The solubility of chitosan in
dilute acids is often needed to be modified when specific drug
release properties have to be tailored into the dosage form. The
available toxicological data on chitosan and its modified forms
appears to indicate its safety for oral use because high doses have
been found to be tolerated well in rodents and rabbits. However,
its local action as a haemostatic together with its ability to
activate macrophages and cause cytokine release may require a
careful assessment of its safety for parenteral use. This book
offers the dynamics of chitosan's detailed composition.
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