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Chemistry is the science of substances (today we would say
molecules) and their transformations. Central to this science is
the complexity of shape and function of its typical
representatives. There lies, no longer dependent on its vitalistic
antecedents, the rich realm of molecular possibility called organic
chemistry. In this century we have learned how to determine the
three-dimensional structure of molecules. Now chemistry as whole,
and organic chemistry in particular, is poised to move to the
exploration of its dynamic dimension, the busy business of
transformations or reactions. Oh, it has been done all along, for
what else is synthesis? What I mean is that the theoretical
framework accom panying organic chemistry, long and fruitfully
laboring on a quantum chemical understanding of structure, is now
making the first tentative motions toward building an organic
theory of reactivity. The Minkin, Simkin, Minyaev book takes us in
that direction. It incorporates the lessons of frontier orbital
theory and of Hartree-Fock SCF calculations; what chemical
physicists have learned about trajectory calculations of selected
reactions, and a simplified treatment of all-important solvent
effects. It is written by professional, accomplished organic
chemists for other organic chemists; it is consistently even-toned
in its presentation of contending approaches. And very much up to
date. That this contemporary work should emerge from a regional
university in a country in which science has been highly
centralized and organic chemistry not very modern, invites
reflection."
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