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Chemical sensors are in high demand for applications as varied as
water pollution detection, medical diagnostics, and battlefield air
analysis. Designing the next generation of sensors requires an
interdisciplinary approach. The book provides a critical analysis
of new opportunities in sensor materials research that have been
opened up with the use of combinatorial and high-throughput
technologies, with emphasis on experimental techniques. For a view
of component selection with a more computational perspective,
readers may refer to the complementary volume of Integrated
Analytical Systems edited by M. Ryan et al., entitled
"Computational Methods for Sensor Material Selection".
The traditional concept of biological sensors, based on enzymatic
receptors and potentiometric or amperometric transducers has
undergone several genera tions of development. Such types of
biosensors have been extensively reviewed, described in many
textbooks and commercialized. This book is focused on alternative
types of chemical and biological sensors or sensor-like structures
and approaches, exploring electrical or electrochemical signal
detection. Spe cial attention is paid to applications of linear and
nonlinear impedance. Some basic ideas in this field are very old -
first described, for example, in the classi cal work by Warburg at
the end of the 19th century. Later impedance spectrosco py became a
popular approach for studying adsorption of organic molecules on
polarizable metal electrodes. However, analytical applications of
this approach have only been developed over the last decade, after
the establishment of the technology of self-assembled monolayers.
In that time, when many scientists were disappointed with attempts
to use the Langmuir-Blodgett technique for manufacturing
electrochemical devices, the self-assembled monolayers became a
viable technology for immobilization of organic molecules on
electrodes and for the formation of covalently stabilized receptor
layers and even more sophis ticated organic nano- and
microstructures. This resulted in the development of numerous
analytical applications of impedometric methods which are the main
topic of the present book. The book consists of four parts."
The traditional concept of biological sensors, based on enzymatic
receptors and potentiometric or amperometric transducers has
undergone several genera tions of development. Such types of
biosensors have been extensively reviewed, described in many
textbooks and commercialized. This book is focused on alternative
types of chemical and biological sensors or sensor-like structures
and approaches, exploring electrical or electrochemical signal
detection. Spe cial attention is paid to applications of linear and
nonlinear impedance. Some basic ideas in this field are very old -
first described, for example, in the classi cal work by Warburg at
the end of the 19th century. Later impedance spectrosco py became a
popular approach for studying adsorption of organic molecules on
polarizable metal electrodes. However, analytical applications of
this approach have only been developed over the last decade, after
the establishment of the technology of self-assembled monolayers.
In that time, when many scientists were disappointed with attempts
to use the Langmuir-Blodgett technique for manufacturing
electrochemical devices, the self-assembled monolayers became a
viable technology for immobilization of organic molecules on
electrodes and for the formation of covalently stabilized receptor
layers and even more sophis ticated organic nano- and
microstructures. This resulted in the development of numerous
analytical applications of impedometric methods which are the main
topic of the present book. The book consists of four parts."
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