This volume presents the proceedings of the 4th International Scientific and Practical Conference on Digital Economy and Finances (DEFIN22) at the Saint-Petersburg University of Management Technologies and Economics (UMTE), which took place in March 2022. It includes the newest research on the impact of new digital technologies on the growth and capitalization of companies and the labor market. The volume discusses the problems of situational modeling of economic processes and the creation of "digital twins" of enterprises. The contributions analyse how big data and artificial intelligence technologies are shaping the financial markets.