This volume presents the Proceedings of the University of Chicago's third Cancer Training Grant supported Teaching Symposium. This Symposium received much of its support from grant number T12 CA 08077-02. Most of the planning of the Symposium and most of the local editing of the Proceedings was carried out by Dr. R. J. Michael Fry of the A.E.C. Argonne National Laboratory and by two members of the Advisory Committee of the Cancer Training Grant, Drs. Melvin Griem and Werner Kirsten. They carried the main responsibility for the Symposium. The subject of the Symposium, "Normal and Malignant Cell Growth," was chosen because, as the Proceedings reflect, it is a rapidly advancing field of endeavor which is of utmost importance to the understanding of the processes of malignant neoplasia. In fact, there is increasing evidence that knowledge of the kinetics of the cancer cell will greatly influence approaches to cancer therapy. Like the first two of these Teaching Symposia held in 1964 and 1966, this one attracted about 400 students and staff from this medical institution as well as from other medical centers in the Chicago area. The effective interplay of an excellent group of scientists with a lively and responsive audience was evident as they considered together a topic of great current interest in the field of neoplasia. Much of the credit for the smooth organization and implementation of the Symposium must go to Mrs.

This volume summarizes the Proceedings of the fourth biennial Cancer Teaching Symposium held on March 7 and 8, 1970, at the University of Chicago Pritzker School of Medicine. The program was prepared by Drs. LAWRENCE ALLEN, MELVIN GRIEM, WERNER KIRSTEN, LEON JACOBSON, JOHN ULTMANN, ROBERT WISSLER, and STANLEY Y ACHNIN. The purpose of the Symposium was to present current advances in the area of lymphoma and leukemia to the staff and students of this medical center and to students and interested physicians from other institutions in the Chicago area. Like the other teaching symposia held in 1964, 1966, and 1968, this Symposium attracted over 450 physicians and scientists. In the course of one and a half days the audience had the opportunity to listen to the twenty-four invited speakers and to lively discussions. The formal presentations as well as discussions are recorded in these pages. This Teaching Symposium could not have been undertaken without the faithful assistance of the Program Committee, the Cancer Training Grant Advisory Com mittee, the staff who recorded and transcribed the Proceedings, and the editorial assistants. We wish to thank the following for their efforts: DOROTHY A. WILLIS, Administrative Secretary for Institutional Cancer Training Grant, Dr. ROBERT L. HUNTER, Dr. ROBERT H. KIRSCHNER, Dr. ROBERT A. ORLANDO, Dr. STEPHEN STRUM, RANDOLPH HUGHES, JULIA KANT, GEORGIA MOHR, TERRY PEARSON, FRIEDA RANNEY, and CAROL REESE. This Symposium received financial support from the Cancer Training Program Tt2 CA 08077-04 and The Chicago Tumor Institute."

(North American) Blastomycosis is caused by the dimorphic fungus Blastomyces dermati- tidis, first described by Gilchrist andStokes in 1896. The perfect stage was grown by Mc- Donough and Lewis in 1967 and is known as Ajellomyces dermatitidis. In the body and on appropriate media at 37 C, the organism presents itself as a round, thick-walled budding yeast cell, characteristically with a broad porus between mother and daughter cells. The yeast cell is multinucleated. For many years, North America was assumed to be the only place where blastomycosis was found, but recent demonstration of indigenous African cases changed this impression (Emmons et al., 1964). Within the United States, more cases are seen in Kentucky, Ohio, the Carolinas, Illinois, Michigan, Wisconsin, Iowa, Tennessee, Arkansas, and the Virginias than in the remainder of the country (Chick, 1971). In Mexico, occasionally, and in the provinces of Canada adjacent to the endemic areas of the United States, endemic blasto- mycosis has been recognized. Soil has been long suspected as the habitat for the fungus, but recovery from soil has seldom been successful (Denton and Di Salvo, 1964). The primary infection is, as a rule, pulmonary with frequent secondary foci in skin, bone, male genital system, and, eventually, spares no organ in widely disseminated cases. The rare cases of primary cutaneous blastomycosis are consequences of accidental percutaneous laboratory infection. These can be clinically easily differentiated from the average case of secondary hematogenous spread to the skin (Landay and Schwarz, 1971).