Delivery Routes to the Lysosome. The Taxonomy of Lysosomes and Related Structures; J.B. Lloyd. Origin of Lysosomal Proteins; T. Braulke. Endocytosis; E. Smythe. Autophagy; E.G. Mortimore, et al. Selective Proteolysis: 70kD Heat Shock Protein and Ubiquitin-Dependent Mechanisms; R.J. Mayer, F.J. Doherty. Metabolism in the Lysosome. Lysosomal Metabolism of Proteins; R.W. Mason. Lysosomal Metabolism of Glycoconjugates; B.G. Winchester. Lysosomal Metabolism of Lipids; W.J. Johnson, et al. Lysosomal Nucleic Acid and Phosphate Metabolism, and Related Metabolic Reactions; R.L. Pisoni. The Lysosome in Its Cytoplasmic Environment. Acidification of Lysosomes and Endosomes; R.W. Van Dyke. Metabolite Efflux and Influx Across the Lysosome Membrane; J.B. Lloyd. Lysosome Pharmacology and Toxicology; R. Wattiaux, S. Wattiaux-De Coninck. Index.

Detailed exploration of an enigmatic manuscript containing the texts to hundreds of songs, but no musical notation. The medieval songbook known variously as trouvere manuscript C or the "Bern Chansonnier" (Bern, Burgerbibliothek, Cod. 389) is one of the most important witnesses to musical life in thirteenth-century France. Almost certainly copied in Metz, it provides the texts to over five hundred Old French songs, and is a unique insight into cultures of song-making and copying on the linguistic and political borders between French and German-speaking lands in the Middle Ages. Notably, the names of trouveres, including several female poet-musicians, are found in its margins, names which would be unknown today without this evidence. However, the manuscript has received relatively little scholarly attention, partly because the songs' musical staves remained empty for reasons now unknown, and partly because of where it was copied. This collection of essays is the first to consider C on its own terms and from a range of disciplinary perspectives, including philology, art history, literary studies, and musicology. The contributors explore the process of creating the complex object that is a music manuscript, examining the work of the scribes and artists who worked on C, and questioning how scribes acquired and organised exemplars for copying. The peculiarly Messine flavour of the repertoire and authors is also discussed, with contributors showing that C frames the tradition of Old French song from a unique perspective. As a whole, the volume demonstrates how in this eastern hub of music and poetry, poet-composers, readers, and scribes interacted with the courtly song tradition in fascinating and unusual ways.

This book charts the history of the last fifty years of the Austro-Hungarian Empire from 1867 to 1918. it reveals that the Habsburg Monarchy, though not in a healthy state before 1914, was not in fact doomed to collapse. The author examines foreign and domestic policies and reveals the weaknesses inherent in the Empire.He also shows how the Austro-Hungarian Empire attempted to satisfy the claims of eleven distinct national groups.

A group of resourceful kids start "solution-seekers.com," a website where "cybervisitors" can get answers to questions that trouble them. But when one questioner asks the true meaning of Christmas, the kids seek to unravel the mystery by journeying back through the prophecies of the Old Testament. What they find is a series of "S" words that reveal a "spectacular story!" With creative characters, humorous dialogue and great music, The "S" Files is a children's Christmas musical your kids will love performing.

This collection of essays, four of which are published in English for the first time, represents the life's work of the historian Tim Mason, one of the most original and perceptive scholars of National Socialism, who pioneered its social and labour history. His provocative articles and essays, written between 1964 and 1990, exhibit a combination of empirical rigour and theoretical astuteness which made them landmarks in the definition and elaboration of major debates in the historiography of National Socialism. These ten essays collect together Mason's most significant writings, including discussions of the domestic origins of the Second World War, the role of Hitler, and the character of working-class resistance, as well as his pathbreaking study of women under National Socialism, and examples of comparative work on fascism and Nazism. A complete bibliography of his publications is also appended.

"Lysosomes are now known tobe notjustacollectionofisolatedorganellesofin- terest only to the biochemist, but part ofa complex, dynamic, membranous sys- tem essential to the cell's economy." So wrote the late Dame Honor Fell and I in the preface to the first volume of Lysosomes in Biology and Pathology almost 30 years ago. We wentonto say thatresearchonthelysosomalsystematthetimewas in a state ofexplosive and chaotic growth. While the chaos has beenlargely reduced, the growthofresearch into the bi- ology ofthe lysosome remains considerable. Biologists worldwide are still fasci- nated by the diversity of activities and the interaction between the various membranous systems of the cell, both in biological and pathological situations. The present volume, edited by John Lloyd and Robert Mason, who have each made major contributions to research in this field, continues to systematize the growthofinformation in this importantarea. Taken together, the twelve chaptersofthis volume form an extensive update ofour knowledge of the biological and physiological role of the lysosomal sys- tem. The book will enhance our knowledge ofcell function and help in our un- derstanding ofthe factors that control cell metabolism in health and disease. John T. Dingle Hughes Hall Cambridge, England ix Preface Lysosomes are still orphan organelles. Even in the 1990s, it is not unknown for members of a scientific or medical audience to reveal, by a question following a lecture, thatthey confuse lysosome with lysozyme or liposome.Andthis ignorance has adeeperreasonthan mereconfusionoversimilar-sounding terms. Itarisesbe- cause Iysosomes exist on the periphery of cell function, rather than at its center.

This is a collection of ten path-breaking essays on the history of the National Socialist regime in Germany. The topics covered here include the origins of the Second World War, the role of Hitler in the Nazi regime, and the position of the working class and of women under National Socialism. Each essay defines or reinterprets a significant debate in the history of the Nazi period. The essays, collected here for the first time, include four hitherto not published in English.

This book charts the history of the last fifty years of the Austro-Hungarian Empire from 1867 to 1918. it reveals that the Habsburg Monarchy, though not in a healthy state before 1914, was not in fact doomed to collapse. The author examines foreign and domestic policies and reveals the weaknesses inherent in the Empire.He also shows how the Austro-Hungarian Empire attempted to satisfy the claims of eleven distinct national groups.

Dieses Buch ist die iiberarbeitete Fassung der Einleitung zu der Quellenedition Arbeiterklasse und Volksgemeinscbaft. Dokumente und Materialien zur deutscben Arbeiterpolitik 1936-1939 (West- deutscher Verlag, Opladen, 1975). Fiir die hiermit getrennt vorge1egte Neuveroffentlichung des Ein- leitungsteils habe ich Kapite1 II fast vollstandig neu geschrieben und dabei erheblich erweitert; ich habe ansonsten die Ge1egenheit be- nutzt, zahlreiche kleine Verbesserungen verschiedenster Art vorzu- nehmen und die Bibliographie zu erganzen. Doch hat die Schrift in starkem Mage den Charakter einer Einleitung beibehalten. Sie ist zwar insofern in sich geschlossen und verstandlich, als die Haupt- linien der Darstellung und Interpretation auch ohne das in der grogen Edition verOffentlichte Aktenmaterial klar hervortreten. Mir liegt aber viel daran, dag das Buch den Leser unter anderem auch zur Lektiire jener Dokumente und MateriaJien anreizt, denn sie vermitteln ein umfassendes, detailliertes und zugleich anschau- liches Bild der Sozialgeschichte des nationalsozialistischen Deutsch- land, wie es keine wissenschaftliche Monographie zu erst ellen ver- mag. Aus diesem Grunde verweisen die Anmerkungen zu diesem Buch nicht auf das urspriingliche Dokument und seinen Fundort, sondern auf die Veroffentlichung in Arbeiterklasse und Volksge- meinschaft: "Vgl. Dok. 154" heigt also z.B., dag das betreffende Aktenstiick als Nr. 154 in dem erwahnten Dokumentenband zu finden ist. Urn solche Verweise iibersichtlicher zu machen, ist ein komplettes Register der 244 in der Quellenedition vorge1egten Do- kumente diesem Buch als Anhang beigegeben (S. 323 ff.).