Unlike some other reproductions of classic texts (1) We have not used OCR(Optical Character Recognition), as this leads to bad quality books with introduced typos. (2) In books where there are images such as portraits, maps, sketches etc We have endeavoured to keep the quality of these images, so they represent accurately the original artefact. Although occasionally there may be certain imperfections with these old texts, we feel they deserve to be made available for future generations to enjoy.

Originally published in 1881 this early work on Fly Fishing in Maines Lakes is both expensive and hard to find in its first edition. It is a fascinating novel and still an interesting read today, It will appeal greatly to the keen angler. Many of the earliest books, particularly those dating back to 1900s and before, are now extremely scarce and increasingly expensive. We are republishing these classic works in affordable, high quality, modern editions, using the original artwork and text.

G Protein-Coupled Receptor Genetics: Research and Methods in the Post-Genomic Era features practical techniques inspired by the fast moving GPCR field. From powerful bioinformatic tools tracing the evolution of GPCRs, to methods for the cellular transfection of engineered viruses containing GPCRs, to optogenetic techniques that produce light-activated GPCRs in live mice, what was once science fiction is now science fact. This detailed volume includes sections covering genetic mechanisms, a genetic toolbox for GPCR discovery, as well as genetic aspects of G protein-coupled receptors in health and medicine. Written for the Methods in Pharmacology and Toxicology series, this book contains the kind of key implementation advice that encourages successful results in the lab. Authoritative and easy to use, G Protein-Coupled Receptor Genetics: Research and Methods in the Post-Genomic Era serves as an ideal guide for researchers aiming to continue our progress in this dynamic and exciting area of study.

The goal of the characterization and discovery of G protein-coupled receptors, arguably the most important class of signaling molecules in humans and other vertebrates, has spawned numerous vital methodologies. In "Methods for the Discovery and Characterization of G Protein-Coupled Receptors," experts in the field present the very latest on the methods and technology used to characterize and discover novel mechanisms of GPCRs which, in many cases, can be used directly to design experiments for the reader s particular GPCR of interest and their specific avenue of investigation. Divided into four convenient sections, this detailed volume covers GPCRs in the genome, trafficking of GPCRs, GPCRs on the membrane, as well as the regulation of these key receptors. Chapters also feature an important section called Future Directions which gives the reader an insight into advances soon to be realized in each area. Written for the popular "Neuromethods" series, this book contains the kind of detailed description and implementation advice that is crucial for getting optimal results.

Authoritative and cutting-edge, "Methods for the Discovery and Characterization of G Protein-Coupled Receptors" serves as an ideal guide for scientists determined to further our knowledge of crucially important set of receptors.

G Protein-Coupled Receptor Genetics: Research and Methods in the Post-Genomic Era features practical techniques inspired by the fast moving GPCR field. From powerful bioinformatic tools tracing the evolution of GPCRs, to methods for the cellular transfection of engineered viruses containing GPCRs, to optogenetic techniques that produce light-activated GPCRs in live mice, what was once science fiction is now science fact. This detailed volume includes sections covering genetic mechanisms, a genetic toolbox for GPCR discovery, as well as genetic aspects of G protein-coupled receptors in health and medicine. Written for the Methods in Pharmacology and Toxicology series, this book contains the kind of key implementation advice that encourages successful results in the lab. Authoritative and easy to use, G Protein-Coupled Receptor Genetics: Research and Methods in the Post-Genomic Era serves as an ideal guide for researchers aiming to continue our progress in this dynamic and exciting area of study.

The goal of the characterization and discovery of G protein-coupled receptors, arguably the most important class of signaling molecules in humans and other vertebrates, has spawned numerous vital methodologies. In Methods for the Discovery and Characterization of G Protein-Coupled Receptors, experts in the field present the very latest on the methods and technology used to characterize and discover novel mechanisms of GPCRs which, in many cases, can be used directly to design experiments for the reader's particular GPCR of interest and their specific avenue of investigation. Divided into four convenient sections, this detailed volume covers GPCRs in the genome, trafficking of GPCRs, GPCRs on the membrane, as well as the regulation of these key receptors. Chapters also feature an important section called "Future Directions" which gives the reader an insight into advances soon to be realized in each area. Written for the popular Neuromethods series, this book contains the kind of detailed description and implementation advice that is crucial for getting optimal results. Authoritative and cutting-edge, Methods for the Discovery and Characterization of G Protein-Coupled Receptors serves as an ideal guide for scientists determined to further our knowledge of crucially important set of receptors.

The Drug Expert: A Practical Guide to the Impact of Drug Use in Legal Proceedings targets academic and industry pharmacologists, pharmacology graduate students, and professionals and students of affiliated disciplines, such as pharmacy and toxicology. Users will find it to be an invaluable reference for those involved in the field. In addition, pharmacists and others who increasingly serve as expert witnesses and toxicologists will find an array of very useful information.

Religion has been on the rise in America for decades-which strikes many as a shocking new development. To the contrary, Jason Stevens asserts, the rumors of the death of God were premature. Americans have always conducted their cultural life through religious symbols, never more so than during the Cold War. In God-Fearing and Free, Stevens discloses how the nation, on top of the world and torn between grandiose self-congratulation and doubt about the future, opened the way for a new master narrative. The book shows how the American public, powered by a national religious revival, was purposefully disillusioned regarding the country's mythical innocence and fortified for an epochal struggle with totalitarianism. Stevens reveals how the Augustinian doctrine of original sin was refurbished and then mobilized in a variety of cultural discourses that aimed to shore up democratic society against threats preying on the nation's internal weaknesses. Suddenly, innocence no longer meant a clear conscience. Instead it became synonymous with totalitarian ideologies of the fascist right or the communist left, whose notions of perfectability were dangerously close to millenarian ideals at the heart of American Protestant tradition. As America became riddled with self-doubt, ruminations on the meaning of power and the future of the globe during the "American Century" renewed the impetus to religion. Covering a wide selection of narrative and cultural forms, Stevens shows how writers, artists, and intellectuals, the devout as well as the nonreligious, disseminated the terms of this cultural dialogue, disputing, refining, and challenging it-effectively making the conservative case against modernity as liberals floundered.

Practical, in-depth knowledge of the system programming interfaces that drive the UNIX and Linux kernels Building on W. Rich Stevens' pioneering work, this third edition of the classic was updated by Steve Rago, a colleague of Stevens, to reflect technical advances and best practices aligning with Version 4 of the Single UNIX Specification. This edition covers more than seventy interfaces including: POSIX asynchronous I/O Spin locks Barriers POSIX semaphores Steve carefully retains the spirit and approach that have made this book so valuable, starting with files, directories, and processes, carefully laying the groundwork for more advanced techniques, such as signal handling and terminal I/O. And he thoroughly covers threads and multithreaded programming, and socket-based IPC. Filled with examples, case-studies, and access to thousands of lines of downloadable code, Advanced Programming in the UNIX (R) Environment has helped generations of programmers write code with exceptional power, performance, and reliability.

"For an engineer determined to refine and secure Internet operation or to explore alternative solutions to persistent problems, the insights provided by this book will be invaluable." -Vint Cerf, Internet pioneer TCP/IP Illustrated, Volume 1, Second Edition, is a detailed and visual guide to today's TCP/IP protocol suite. Fully updated for the newest innovations, it demonstrates each protocol in action through realistic examples from modern Linux, Windows, and Mac OS environments. There's no better way to discover why TCP/IP works as it does, how it reacts to common conditions, and how to apply it in your own applications and networks. Building on the late W. Richard Stevens' classic first edition, author Kevin R. Fall adds his cutting-edge experience as a leader in TCP/IP protocol research, updating the book to fully reflect the latest protocols and best practices. He first introduces TCP/IP's core goals and architectural concepts, showing how they can robustly connect diverse networks and support multiple services running concurrently. Next, he carefully explains Internet addressing in both IPv4 and IPv6 networks. Then, he walks through TCP/IP's structure and function from the bottom up: from link layer protocols-such as Ethernet and Wi-Fi-through network, transport, and application layers. Fall thoroughly introduces ARP, DHCP, NAT, firewalls, ICMPv4/ICMPv6, broadcasting, multicasting, UDP, DNS, and much more. He offers extensive coverage of reliable transport and TCP, including connection management, timeout, retransmission, interactive data flow, and congestion control. Finally, he introduces the basics of security and cryptography, and illuminates the crucial modern protocols for protecting security and privacy, including EAP, IPsec, TLS, DNSSEC, and DKIM. Whatever your TCP/IP experience, this book will help you gain a deeper, more intuitive understanding of the entire protocol suite so you can build better applications and run more reliable, efficient networks.