G Protein-Coupled Receptor Genetics: Research and Methods in the Post-Genomic Era features practical techniques inspired by the fast moving GPCR field. From powerful bioinformatic tools tracing the evolution of GPCRs, to methods for the cellular transfection of engineered viruses containing GPCRs, to optogenetic techniques that produce light-activated GPCRs in live mice, what was once science fiction is now science fact. This detailed volume includes sections covering genetic mechanisms, a genetic toolbox for GPCR discovery, as well as genetic aspects of G protein-coupled receptors in health and medicine. Written for the Methods in Pharmacology and Toxicology series, this book contains the kind of key implementation advice that encourages successful results in the lab. Authoritative and easy to use, G Protein-Coupled Receptor Genetics: Research and Methods in the Post-Genomic Era serves as an ideal guide for researchers aiming to continue our progress in this dynamic and exciting area of study.

The goal of the characterization and discovery of G protein-coupled receptors, arguably the most important class of signaling molecules in humans and other vertebrates, has spawned numerous vital methodologies. In Methods for the Discovery and Characterization of G Protein-Coupled Receptors, experts in the field present the very latest on the methods and technology used to characterize and discover novel mechanisms of GPCRs which, in many cases, can be used directly to design experiments for the reader's particular GPCR of interest and their specific avenue of investigation. Divided into four convenient sections, this detailed volume covers GPCRs in the genome, trafficking of GPCRs, GPCRs on the membrane, as well as the regulation of these key receptors. Chapters also feature an important section called "Future Directions" which gives the reader an insight into advances soon to be realized in each area. Written for the popular Neuromethods series, this book contains the kind of detailed description and implementation advice that is crucial for getting optimal results. Authoritative and cutting-edge, Methods for the Discovery and Characterization of G Protein-Coupled Receptors serves as an ideal guide for scientists determined to further our knowledge of crucially important set of receptors.

G Protein-Coupled Receptor Genetics: Research and Methods in the Post-Genomic Era features practical techniques inspired by the fast moving GPCR field. From powerful bioinformatic tools tracing the evolution of GPCRs, to methods for the cellular transfection of engineered viruses containing GPCRs, to optogenetic techniques that produce light-activated GPCRs in live mice, what was once science fiction is now science fact. This detailed volume includes sections covering genetic mechanisms, a genetic toolbox for GPCR discovery, as well as genetic aspects of G protein-coupled receptors in health and medicine. Written for the Methods in Pharmacology and Toxicology series, this book contains the kind of key implementation advice that encourages successful results in the lab. Authoritative and easy to use, G Protein-Coupled Receptor Genetics: Research and Methods in the Post-Genomic Era serves as an ideal guide for researchers aiming to continue our progress in this dynamic and exciting area of study.

The goal of the characterization and discovery of G protein-coupled receptors, arguably the most important class of signaling molecules in humans and other vertebrates, has spawned numerous vital methodologies. In "Methods for the Discovery and Characterization of G Protein-Coupled Receptors," experts in the field present the very latest on the methods and technology used to characterize and discover novel mechanisms of GPCRs which, in many cases, can be used directly to design experiments for the reader s particular GPCR of interest and their specific avenue of investigation. Divided into four convenient sections, this detailed volume covers GPCRs in the genome, trafficking of GPCRs, GPCRs on the membrane, as well as the regulation of these key receptors. Chapters also feature an important section called Future Directions which gives the reader an insight into advances soon to be realized in each area. Written for the popular "Neuromethods" series, this book contains the kind of detailed description and implementation advice that is crucial for getting optimal results.

Authoritative and cutting-edge, "Methods for the Discovery and Characterization of G Protein-Coupled Receptors" serves as an ideal guide for scientists determined to further our knowledge of crucially important set of receptors.

Religion has been on the rise in America for decades-which strikes many as a shocking new development. To the contrary, Jason Stevens asserts, the rumors of the death of God were premature. Americans have always conducted their cultural life through religious symbols, never more so than during the Cold War. In God-Fearing and Free, Stevens discloses how the nation, on top of the world and torn between grandiose self-congratulation and doubt about the future, opened the way for a new master narrative. The book shows how the American public, powered by a national religious revival, was purposefully disillusioned regarding the country's mythical innocence and fortified for an epochal struggle with totalitarianism. Stevens reveals how the Augustinian doctrine of original sin was refurbished and then mobilized in a variety of cultural discourses that aimed to shore up democratic society against threats preying on the nation's internal weaknesses. Suddenly, innocence no longer meant a clear conscience. Instead it became synonymous with totalitarian ideologies of the fascist right or the communist left, whose notions of perfectability were dangerously close to millenarian ideals at the heart of American Protestant tradition. As America became riddled with self-doubt, ruminations on the meaning of power and the future of the globe during the "American Century" renewed the impetus to religion. Covering a wide selection of narrative and cultural forms, Stevens shows how writers, artists, and intellectuals, the devout as well as the nonreligious, disseminated the terms of this cultural dialogue, disputing, refining, and challenging it-effectively making the conservative case against modernity as liberals floundered.

Practical, in-depth knowledge of the system programming interfaces that drive the UNIX and Linux kernels Building on W. Rich Stevens' pioneering work, this third edition of the classic was updated by Steve Rago, a colleague of Stevens, to reflect technical advances and best practices aligning with Version 4 of the Single UNIX Specification. This edition covers more than seventy interfaces including: POSIX asynchronous I/O Spin locks Barriers POSIX semaphores Steve carefully retains the spirit and approach that have made this book so valuable, starting with files, directories, and processes, carefully laying the groundwork for more advanced techniques, such as signal handling and terminal I/O. And he thoroughly covers threads and multithreaded programming, and socket-based IPC. Filled with examples, case-studies, and access to thousands of lines of downloadable code, Advanced Programming in the UNIX (R) Environment has helped generations of programmers write code with exceptional power, performance, and reliability.

The Drug Expert: A Practical Guide to the Impact of Drug Use in Legal Proceedings targets academic and industry pharmacologists, pharmacology graduate students, and professionals and students of affiliated disciplines, such as pharmacy and toxicology. Users will find it to be an invaluable reference for those involved in the field. In addition, pharmacists and others who increasingly serve as expert witnesses and toxicologists will find an array of very useful information.

The Sissification Of America: A Fifty-Year Decline In American Exceptionalism, is a nonfiction narrative which addresses current events within the context of comparing America's vibrant history to its contemporary era. The book specifically examines how the federal government and some of our nation's public and private institutions have gradually led the nation down a precipitous fifty-year decline of virtues that once made America unique in world history. This intriguing book focuses on American virtues consisting of: a spirit of independence and rugged individualism, a thriving work ethic, honesty, capitalism, competition, excellence in education, limited government, Godliness, and a Judaic-Christian rectitude of impeccable character. While these virtues are still evident in America today, they exist to a much lesser degree when compared to the years between 1620 and 1961. The seven chapters of this book touch upon many topics that correlate directly with these unique American virtues and their declining influence upon society such as: the demise of common sense; the continual assault being waged upon the individual rights and freedoms of all Americans; the squelching of states' rights by the leviathan federal government; the breakdown of the traditional family unit due to fatherless homes, the feminization of our culture, the feminization of America's public schools, and the feminization of our nation's men and boys; last-but certainly not least-the controversial issues confronting America's public schools and teachers. Be prepared to experience a wild roller coaster ride as you read The Sissification of America: A Fifty-Year Decline in American Exceptionalism

Title: Adventures, American anecdotes: biographical, historical, and descriptive.Author: George W StevensPublisher: Gale, Sabin Americana Description: Based on Joseph Sabin's famed bibliography, Bibliotheca Americana, Sabin Americana, 1500--1926 contains a collection of books, pamphlets, serials and other works about the Americas, from the time of their discovery to the early 1900s. Sabin Americana is rich in original accounts of discovery and exploration, pioneering and westward expansion, the U.S. Civil War and other military actions, Native Americans, slavery and abolition, religious history and more.Sabin Americana offers an up-close perspective on life in the western hemisphere, encompassing the arrival of the Europeans on the shores of North America in the late 15th century to the first decades of the 20th century. Covering a span of over 400 years in North, Central and South America as well as the Caribbean, this collection highlights the society, politics, religious beliefs, culture, contemporary opinions and momentous events of the time. It provides access to documents from an assortment of genres, sermons, political tracts, newspapers, books, pamphlets, maps, legislation, literature and more.Now for the first time, these high-quality digital scans of original works are available via print-on-demand, making them readily accessible to libraries, students, independent scholars, and readers of all ages.++++The below data was compiled from various identification fields in the bibliographic record of this title. This data is provided as an additional tool in helping to insure edition identification: ++++SourceLibrary: Huntington LibraryDocumentID: SABCP03322500CollectionID: CTRG00-B979PublicationDate: 18450101SourceBibCitation: Selected Americana from Sabin's Dictionary of books relating to AmericaNotes: Collation: 224 p