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Unlike some other reproductions of classic texts (1) We have not
used OCR(Optical Character Recognition), as this leads to bad
quality books with introduced typos. (2) In books where there are
images such as portraits, maps, sketches etc We have endeavoured to
keep the quality of these images, so they represent accurately the
original artefact. Although occasionally there may be certain
imperfections with these old texts, we feel they deserve to be made
available for future generations to enjoy.
Originally published in 1881 this early work on Fly Fishing in
Maines Lakes is both expensive and hard to find in its first
edition. It is a fascinating novel and still an interesting read
today, It will appeal greatly to the keen angler. Many of the
earliest books, particularly those dating back to 1900s and before,
are now extremely scarce and increasingly expensive. We are
republishing these classic works in affordable, high quality,
modern editions, using the original artwork and text.
G Protein-Coupled Receptor Genetics: Research and Methods in the
Post-Genomic Era features practical techniques inspired by the fast
moving GPCR field. From powerful bioinformatic tools tracing the
evolution of GPCRs, to methods for the cellular transfection of
engineered viruses containing GPCRs, to optogenetic techniques that
produce light-activated GPCRs in live mice, what was once science
fiction is now science fact. This detailed volume includes sections
covering genetic mechanisms, a genetic toolbox for GPCR discovery,
as well as genetic aspects of G protein-coupled receptors in health
and medicine. Written for the Methods in Pharmacology and
Toxicology series, this book contains the kind of key
implementation advice that encourages successful results in the
lab. Authoritative and easy to use, G Protein-Coupled Receptor
Genetics: Research and Methods in the Post-Genomic Era serves as an
ideal guide for researchers aiming to continue our progress in this
dynamic and exciting area of study.
The goal of the characterization and discovery of G
protein-coupled receptors, arguably the most important class of
signaling molecules in humans and other vertebrates, has spawned
numerous vital methodologies. In "Methods for the Discovery and
Characterization of G Protein-Coupled Receptors," experts in the
field present the very latest on the methods and technology used to
characterize and discover novel mechanisms of GPCRs which, in many
cases, can be used directly to design experiments for the reader s
particular GPCR of interest and their specific avenue of
investigation. Divided into four convenient sections, this detailed
volume covers GPCRs in the genome, trafficking of GPCRs, GPCRs on
the membrane, as well as the regulation of these key receptors.
Chapters also feature an important section called Future Directions
which gives the reader an insight into advances soon to be realized
in each area. Written for the popular "Neuromethods" series, this
book contains the kind of detailed description and implementation
advice that is crucial for getting optimal results.
Authoritative and cutting-edge, "Methods for the Discovery and
Characterization of G Protein-Coupled Receptors" serves as an ideal
guide for scientists determined to further our knowledge of
crucially important set of receptors.
G Protein-Coupled Receptor Genetics: Research and Methods in the
Post-Genomic Era features practical techniques inspired by the fast
moving GPCR field. From powerful bioinformatic tools tracing the
evolution of GPCRs, to methods for the cellular transfection of
engineered viruses containing GPCRs, to optogenetic techniques that
produce light-activated GPCRs in live mice, what was once science
fiction is now science fact. This detailed volume includes sections
covering genetic mechanisms, a genetic toolbox for GPCR discovery,
as well as genetic aspects of G protein-coupled receptors in health
and medicine. Written for the Methods in Pharmacology and
Toxicology series, this book contains the kind of key
implementation advice that encourages successful results in the
lab. Authoritative and easy to use, G Protein-Coupled Receptor
Genetics: Research and Methods in the Post-Genomic Era serves as an
ideal guide for researchers aiming to continue our progress in this
dynamic and exciting area of study.
The goal of the characterization and discovery of G protein-coupled
receptors, arguably the most important class of signaling molecules
in humans and other vertebrates, has spawned numerous vital
methodologies. In Methods for the Discovery and Characterization of
G Protein-Coupled Receptors, experts in the field present the very
latest on the methods and technology used to characterize and
discover novel mechanisms of GPCRs which, in many cases, can be
used directly to design experiments for the reader's particular
GPCR of interest and their specific avenue of investigation.
Divided into four convenient sections, this detailed volume covers
GPCRs in the genome, trafficking of GPCRs, GPCRs on the membrane,
as well as the regulation of these key receptors. Chapters also
feature an important section called "Future Directions" which gives
the reader an insight into advances soon to be realized in each
area. Written for the popular Neuromethods series, this book
contains the kind of detailed description and implementation advice
that is crucial for getting optimal results. Authoritative and
cutting-edge, Methods for the Discovery and Characterization of G
Protein-Coupled Receptors serves as an ideal guide for scientists
determined to further our knowledge of crucially important set of
receptors.
The Drug Expert: A Practical Guide to the Impact of Drug Use in
Legal Proceedings targets academic and industry pharmacologists,
pharmacology graduate students, and professionals and students of
affiliated disciplines, such as pharmacy and toxicology. Users will
find it to be an invaluable reference for those involved in the
field. In addition, pharmacists and others who increasingly serve
as expert witnesses and toxicologists will find an array of very
useful information.
Religion has been on the rise in America for decades-which strikes
many as a shocking new development. To the contrary, Jason Stevens
asserts, the rumors of the death of God were premature. Americans
have always conducted their cultural life through religious
symbols, never more so than during the Cold War. In God-Fearing and
Free, Stevens discloses how the nation, on top of the world and
torn between grandiose self-congratulation and doubt about the
future, opened the way for a new master narrative. The book shows
how the American public, powered by a national religious revival,
was purposefully disillusioned regarding the country's mythical
innocence and fortified for an epochal struggle with
totalitarianism. Stevens reveals how the Augustinian doctrine of
original sin was refurbished and then mobilized in a variety of
cultural discourses that aimed to shore up democratic society
against threats preying on the nation's internal weaknesses.
Suddenly, innocence no longer meant a clear conscience. Instead it
became synonymous with totalitarian ideologies of the fascist right
or the communist left, whose notions of perfectability were
dangerously close to millenarian ideals at the heart of American
Protestant tradition. As America became riddled with self-doubt,
ruminations on the meaning of power and the future of the globe
during the "American Century" renewed the impetus to religion.
Covering a wide selection of narrative and cultural forms, Stevens
shows how writers, artists, and intellectuals, the devout as well
as the nonreligious, disseminated the terms of this cultural
dialogue, disputing, refining, and challenging it-effectively
making the conservative case against modernity as liberals
floundered.
Practical, in-depth knowledge of the system programming interfaces
that drive the UNIX and Linux kernels Building on W. Rich Stevens'
pioneering work, this third edition of the classic was updated by
Steve Rago, a colleague of Stevens, to reflect technical advances
and best practices aligning with Version 4 of the Single UNIX
Specification. This edition covers more than seventy interfaces
including: POSIX asynchronous I/O Spin locks Barriers POSIX
semaphores Steve carefully retains the spirit and approach that
have made this book so valuable, starting with files, directories,
and processes, carefully laying the groundwork for more advanced
techniques, such as signal handling and terminal I/O. And he
thoroughly covers threads and multithreaded programming, and
socket-based IPC. Filled with examples, case-studies, and access to
thousands of lines of downloadable code, Advanced Programming in
the UNIX (R) Environment has helped generations of programmers
write code with exceptional power, performance, and reliability.
"For an engineer determined to refine and secure Internet operation
or to explore alternative solutions to persistent problems, the
insights provided by this book will be invaluable." -Vint Cerf,
Internet pioneer TCP/IP Illustrated, Volume 1, Second Edition, is a
detailed and visual guide to today's TCP/IP protocol suite. Fully
updated for the newest innovations, it demonstrates each protocol
in action through realistic examples from modern Linux, Windows,
and Mac OS environments. There's no better way to discover why
TCP/IP works as it does, how it reacts to common conditions, and
how to apply it in your own applications and networks. Building on
the late W. Richard Stevens' classic first edition, author Kevin R.
Fall adds his cutting-edge experience as a leader in TCP/IP
protocol research, updating the book to fully reflect the latest
protocols and best practices. He first introduces TCP/IP's core
goals and architectural concepts, showing how they can robustly
connect diverse networks and support multiple services running
concurrently. Next, he carefully explains Internet addressing in
both IPv4 and IPv6 networks. Then, he walks through TCP/IP's
structure and function from the bottom up: from link layer
protocols-such as Ethernet and Wi-Fi-through network, transport,
and application layers. Fall thoroughly introduces ARP, DHCP, NAT,
firewalls, ICMPv4/ICMPv6, broadcasting, multicasting, UDP, DNS, and
much more. He offers extensive coverage of reliable transport and
TCP, including connection management, timeout, retransmission,
interactive data flow, and congestion control. Finally, he
introduces the basics of security and cryptography, and illuminates
the crucial modern protocols for protecting security and privacy,
including EAP, IPsec, TLS, DNSSEC, and DKIM. Whatever your TCP/IP
experience, this book will help you gain a deeper, more intuitive
understanding of the entire protocol suite so you can build better
applications and run more reliable, efficient networks.
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