Men's biological clocks may not be ticking loudly, but what about the social clock? Are there benefits to being in-step with social norms for the timing of parenthood? In a clear and accessible style, this book examines the advantages and disadvantages of early, on-time, and delayed first fatherhood. The book includes a foreword by Ross D. Parke.

This volume covers all methods used to discover the composition, structure, and dynamics of the nuclear pore complex (NPC), as well as the soluble transport factors involved in the transport process. Chapters detail structural biology methods, biophysical, transport factors , and a wide range of model organisms that have been used over the years. Written in the format of the highly successful Methods in Molecular Biology series, each chapter includes an introduction to the topic, lists necessary materials and reagents, includes tips on troubleshooting and known pitfalls, and step-by-step, readily reproducible protocols. Authoritative and cutting-edge, The Nuclear Pore Complex: Methods and Protocols: Methods and Protocols aims to be a useful and practical guide to new researchers and experts looking to expand their knowledge.

Health Reform Policy to Practice: Oregon as a Case Study for a Path to a Comprehensive and Sustainable Health Delivery Model offers a real world example of an innovative, successful and comprehensive program conducted by the U.S. State of Oregon. In 1991, Oregon embarked on a journey to improve health for all its citizens by radically re-thinking how to approach health care for long-term benefits. Over more than two decades, Oregonians have participated in a dialogue to create a new approach to solve the dilemma of providing high quality health care that is affordable and effective. Traditionally, health care reform looked at cutting people from care, cutting provider rates or cutting services. Oregon's approach is unique in that it built a new system of delivery from the ground (community) up. The Oregon model took a "Fourth Path" to health care by redesigning the clinical delivery system through reducing waste, improving individual health and prevention, and therefore reducing utilization of services, creating local accountability, aligning financial incentives and creating fiscal accountability. This is not only an Oregon story, but a national one as other states, payers and purchasers implement health care reform.

This book constitutes the refereed proceedings of the 8th International Workshop on Internet and Network Economics, WINE 2012, held in Liverpool, UK, in December 2012. The 36 revised full papers and 13 revised short papers presented together with the abstracts of 3 papers about work in progress and 3 invited talks were carefully reviewed and selected from 112 submissions. The papers are organized in topical sections on algorithmic game theory; algorithmic mechanism design; auction algorithms and analysis; computational advertising; computational aspects of equilibria; computational social choice; convergence and learning in games; coalitions, coordination and collective action; economics aspects of security and privacy; economics aspects of distributed and network computing; information and attention economics; network games; price differentiation and price dynamics; social networks.

Kinase inhibition remains an area of significant interest, and growing importance, across academia and the pharmaceutical industry. There are now many marketed drugs that target kinases and a significant number of compounds are currently in various stages of clinical development. This book is a forward-looking analysis of a number of key areas for kinase inhibition in the coming years and builds on the first volume. This includes topics such as screening approaches to target kinases along with different modes of inhibition such as allosteric and covalent. Novel approaches such as macrocyclisation are considered along with how the properties of kinase inhibitors have evolved, including the potential for brain penetration. Recent areas of great importance also covered include cutting edge molecular modelling approaches and the importance of kinase mutations. The evolving biology of kinases has also resulted in increased interest in the immuno-oncology area and also pseudokinases as a target family. As with the first volume the book finishes with a forward looking view of how research against this fascinating target class may evolve.

This volume covers all methods used to discover the composition, structure, and dynamics of the nuclear pore complex (NPC), as well as the soluble transport factors involved in the transport process. Chapters detail structural biology methods, biophysical, transport factors , and a wide range of model organisms that have been used over the years. Written in the format of the highly successful Methods in Molecular Biology series, each chapter includes an introduction to the topic, lists necessary materials and reagents, includes tips on troubleshooting and known pitfalls, and step-by-step, readily reproducible protocols.  Authoritative and cutting-edge, The Nuclear Pore Complex: Methods and Protocols: Methods and Protocols aims to be a useful and practical guide to new researchers and experts looking to expand their knowledge. 

Men's biological clocks may not be ticking loudly, but what about the social clock? Are there benefits to being in-step with social norms for the timing of parenthood? In a clear and accessible style, this book examines the advantages and disadvantages of early, on-time, and delayed first fatherhood. The book includes a foreword by Ross D. Parke.