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Transferring hematopoietic stem cells and immune cells has continued to be a promising therapeutic alternative and a fascinating area of cell biology as well as a field of persistent procedural problems. This explains why substantial parts of basic research on cell growth and differentiation, immune tolerance and antitumor effects, gene transfer, minimal residual disease and supportive care have settled around clinical transplantation in hematology and oncology. This second volume updates the current role of allogeneic and autologous transplantation in leukemias, lymphomas and solid cancers, including controversial strategies and novel experimental approaches. Outstanding representatives of leading groups guarantee first-hand information and indicate how we can work and cooperate more effectively to the benefit of our patients.
Some three decades after bone marrow transplantation was introduced
in the field of hematology and oncology, transplantation today
continues to rapidly grow and expand into a variety of new
modalities. Peripheral blood has been established as an effective
source of autologous progenitor cells. Furthermore, the
graft-versus-leukemia effect has resulted in novel strategies of
adoptive immunotherapy for cancer. Finally, approaches to gene
transfer and therapy are utilizing transplantation methodologies
and can augment their effects. Current results, new developments
and perspectives are presented in this volume. Conventional and
innovative experimental approaches, the past and the future of bone
marrow transplantation are reviewed and discussed by leading
representatives.
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