This is a little book with no great pretensions. The authors do not claim it to be world-startling nor Nobel- or Pulitzer-prize-winning. It is a valuable primer for pharmacokinetics for those desiring a proper initiation into previously assumed mysteries. It is fully intended as an introduction to the basic concept of pharmacokinetics and will be welcomed by all who wish to apply its principles to their own disciplines, whether in life sciences or medicine, without being confused by excess mathematics. It is edited by two well-known German scientists who are primarily practicing pediatricians and who use pharmacokinetics in their daily work, in a field of medicine where the proper adjustment of doses for infants and children is a delicate and life-preserving art. They were trained as pediatricians and as pharmacokinetists by the world-renowned Profes sor F. HARTMUT DOST, who uniquely synthesized these two disciplines and who, as a pioneer in this field, published the first book on pharmacokine tics in 1953. In their own right, the editors have conducted excellent and unique research on the effect and fate of drugs and have followed up the unexpected changes in drug action accompanying the rapid developments encountered in the initial hours, days, and weeks after birth. You will find some interesting Germanisms in this book a la Professor DOST. I personally feel that these will give some spice to their renditions.

2. Elimination . . . . . . . . . 102 a) Krankhafte Veranderungen des eliminierenden Organs 102 b) Altersabhangige Veranderungen der Elimination . . . 104 c) Pharmakogenetische Faktoren. . . . . . . . . . . 105 d) Abhangigkeit der Eliminationsgeschwindigkeit vom Saure-Basen- Haushalt . . . . . . . . . . . . . . . . . . . 106 e) Cicadiane Rhythmik der Eliminationsgeschwindigkeit . 108 f) Wasserdiurese und Eliminationsgeschwindigkeit 108 g) Loesungsmittelmangel . . . . . . . . . . . . . . 108 h) Enzyminduktion . . . . . . . . . . . . . . . . 109 i) Hemmung der Elimination durch toxische Wirkung. 113 cx) Verdrangung aus der Eiweissbindung . . . . . . 113 ss) Clearancedepression . . . . . . . . . . . . . 114 y) Beschleunigung der Elimination durch enteral verabreichte Komplexbildner und Adsorbentien 114 3. Verteilungsvolumen . . . . . . 115 a) Dehydratation - Hydratation 115 b) Hydropische Zustande 116 4. Schlussbemerkung . . . . . . 116 IX. Verwendung von Analog-Rechnern in der Pharmakokinetik . 118 1. Einfuhrung . . . . . . . . . . . . . 118 2. Arbeitsprinzip des Analogrechners. . . . 119 3. Die Programmierung des Analogrechners . 122 4. Anwendung . . . . . . . . . . . . . 124 x. Praktische Anwendung pharmakokinetischer Verfahren . . . . . . . . 130 (Von W. -H. Wagner) 1. Einleitung. . . . . . 130 2. Messverfahren . . . . 130 130 a) Mikrobiologische Methode 131 b) Chemisch-analytische Methode. c) Nachweis mittels radioaktiv markierter Substanz 131 3. Bewertung der Ergebnisse von Tierversuchen . . . 132 4. Gewinnung pharmakokinetischer Groessen und Konstanten . 133 a) Bestimmung aus der graphischen Darstellung . . . . 133 b) Verwendung programmierter Verfahren. . . . . . . . 133 5. Mathematische Grundlagen der programmierten Verfahren. 134 XI a) Verteilung einer Substanz in mehreren Kompartimenten. 134 b) Blutspiegelverlaufe bei reiner Invasion. . . . . . . . . 135 c) Blutspiegelverlaufe bei reiner Elimination . . . . . . . 137 d) Blutspiegelverlaufe bei gleichzeitiger Invasion und Elimination (Bateman-Funktion) . . 137 e) Kumulation, Grenzkurve 142 f) Dosierungsschema 142 6. Auswertungsbeispiele . 143 Weiterfuhrende Literatur. 154 Sachverzeichnis . . . .

Praise for Investment Management

"A compelling analysis of the challenges of investment management, and why investment management firms require innovation to succeed."
--Blake Grossman, CEO, Barclays Global Investors

"Great investment managers understand that positioning portfolios for clients should not be an act of conformity, but rather a constant journey of shifting fundamentals and opinion. Wayne and Ralph bring this fact to life by addressing some of the key challenges to serious investment thinking, using top-level researchers in their respective fields. For those investment managers and clients who want to go beyond the ordinary."
--Jeff Diermeier, former CEO of CFA Institute and retired CIO of UBS Global Asset Management

"The essays in this book provide an invaluable reference point of serious readings for money managers. The works provide the analyst with the most recent scholarship in a single book, presenting ideas and philosophy that will lead me back to its various sections time and time again."
--Kenneth S. Hackel, CFA, President, CT Capital LLC

"The crash of 2007-2009 brought a harsh conclusion to a quarter of a century of unprecedented growth and prosperity for the investment management industry, which faces no less a task than reinventing itself. Rieves' and Wagner's contribution to the way forward couldn't be timelier."
--Richard Ennis, Principal, Ennis Knupp + Associates

"This book uniformly focuses on the best practices to which investment management professionals should commit. I highly recommend this book to investment managers, sales people, and trustees of pensions, endowments, trusts, and mutual funds."
--Jack Clark Francis, PhD, Professor of Economics and Finance, Bernard Baruch College