An exciting contribution to the field, Visual Dysfunction in Diabetes: The Science of Patient Impairment and Improvement is designed with two overriding objectives: to help readers understand the impact of vision impairment in people living daily with diabetes rather than considering diabetic retinopathy solely as a medical problem, and to explore what we know and don't know about the ways diabetes affect the eye. With the plethora of new information being generated, there are still a series of fundamental questions that must be addressed if effective treatments for diabetic retinopathy are to be found and applied. Developed by a renowned group of authorities, Visual Dysfunction in Diabetes: The Science of Patient Impairment and Improvement offers responses and context for a range of questions, such as: do metabolic factors beyond glucose contribute to vision-threatening diabetic retinopathy? If so, how do these lead to vision impairment? Is diabetic retinopathy a response to systemic metabolic abnormalities or are there unique ocular problems related to insulin resistance? What is the relationship between the neural, vascular, and inflammatory abnormalities in diabetic retinopathy? Do they represent a pathological cascade induced sequentially or simultaneous responses to one or more metabolic perturbations? The authors note that if we do not address these types of questions, it is possible that the long process of developing new therapeutic s will target only one arm of the pathology and leave the retina open to damaging consequences of the others. State-of-the-art, comprehensive, and an invaluable addition the research and clinical literature, Visual Dysfunction in Diabetes: The Science of Patient Impairment and Improvement offers guidance and a significant step toward new scientific approaches that can lessen the devastating vision impairment associated with diabetes.

In the newly revised seventh edition of Managing Quality: Integrating the Supply Chain, a decorated team of operations experts delivers a thorough introduction to quality management with an enduring emphasis on the importance of the supply chain for quality improvement. You'll obtain an integrated understanding of the customers, suppliers, technology, and people essential to maintaining and enhancing product quality in business.

This latest edition combines the unifying theme of the supply chain with the latest developments in critical subject areas, like Lean, Six Sigma, and service quality. Updated vignettes and references maintain the currency of the work, while new content expands its scope and increases readability and accessibility for students of operations, quality management, and business.

Studies on Retinal and Choroidal Disorders examines the role that oxidative and nitrosative stress plays in the complex physiology and pathophysiology of the retina and choroid. Both the basic science researcher and the clinical practitioner can use this book as a guide to the current understanding of retinal and choroidal cellular mechanisms involved in aging and disease. Beginning with a review of oxidative stress and inflammation in the pathoetiology of AMD and a review of the complement system in the retina, the book then takes a detailed look at oxidative stress in lipid metabolism and oxidized lipoproteins in the retina. It examines the anti-apoptotic activity of -crystallins in the presence of glutathione, oxidative stress in the mitochondria and endoplasmic reticulum, the role of iron in retinal disease, the mechanisms of pathological VEGF expression, NAPDH oxidase mechanisms, and Hepatocyte Growth Factor in oxidative stress in the retina. A detailed look at the Ccl2-/-/Cx3cr1-/- mouse model of AMD follows. Then a detailed examination of the systemic changes in AMD is followed by a discussion of cerium oxide nanoparticle reduction of oxidative stress. Two chapters discuss progenitor cells in the cause and treatment of retinal diseases including AMD and diabetic retinopathy. Natural compounds in the prevention and treatment of retinal diseases are exhaustively presented, followed by a chapter on serotonin 5-HT1A receptor agonists in oxidative stress of the retina. The current anti-VEGF treatment strategies of neovascular AMD are then given. The volume continues with a detailed look at nitric oxide and inducible nitric oxide synthase in retinal vascular disease, an explanation of an in vivo technique of studying the effect of lipid hydroperoxides on circulating leucocytes in the retina, an excellent review of oxidative stress in retinopathy of prematurity, and a look at VEGF induced oxidative stress in the retinal ganglion cell. The book ends with a detail examination of the role of carotenoids in retinal health and disease. These 31 chapters summarize what is known about oxidative stress in retinal and choroidal disorders. All those involved with degenerative diseases of the eye will find Studies on Retinal and Choroidal Disorders to be illuminating and comprehensive.

Electronic Noses and Olfaction 2000 reflects the state of progress toward the development and application of electronic instruments called electronic noses (e-noses). These instruments are generally based on arrays of sensors for volatile chemicals with broadly tuned selectivity, coupled to appropriate pattern recognition systems. They are capable of detecting and discriminating a number of different simple and complex odors, such as the headspace of coffee and olive oil, as well as being able to perform simple multicomponent gas analysis. Written by international scientists, engineers, technologists, clinicians, investigators, and instrument manufacturers working in the applied research of e-noses as well as in the applications of olfaction and taste, this volume is essential reading for anyone who wants a review of the latest developments in odor sensors, instrumentation and signal processing, and their medical, agricultural, and food-related applications.

Discipline Over Punishment is an exploration of the transformative potential of restorative discipline practices in schools, ranging from the micro-level of one-on-one interactions with students to the macro-level of re-routing the school-to-prison pipeline and improving life outcomes for young people. Gardner, who continues to teach high school in Oakland, CA, has spent nearly 20 years innovating, struggling, and succeeding to implement various restorative justice practices in classrooms and schools around the Bay Area. Using classrooms and schools where he has taught and students, families and educators with whom he has worked, Gardner examines how restorative justice, as a set of beliefs and practices can be a force for justice and equity in our classrooms, schools, and beyond.

Discipline Over Punishment is an exploration of the transformative potential of restorative discipline practices in schools, ranging from the micro-level of one-on-one interactions with students to the macro-level of re-routing the school-to-prison pipeline and improving life outcomes for young people. Gardner, who continues to teach high school in Oakland, CA, has spent nearly 20 years innovating, struggling, and succeeding to implement various restorative justice practices in classrooms and schools around the Bay Area. Using classrooms and schools where he has taught and students, families and educators with whom he has worked, Gardner examines how restorative justice, as a set of beliefs and practices can be a force for justice and equity in our classrooms, schools, and beyond.

Chemical Intolerance identifies phenolic (aromatic) chemical compounds present in natural foodstuffs, pollens, certain food additives, tobacco smoke, perfumes, air pollution, etc., as nonimmunologic, but pharmacologic activators of allergic reactions in chemically intolerant individuals. Biochemical pathway sequences, with supporting scientific literature, are outlined to elucidate the mechanisms associated with formation of inflammatory mediators (prostaglandins, thromboxanes, and leukotrienes) upon activation by phenolic compounds and other chemical stimulants. The role of these inflammatory agents in respiratory, gastrointestinal, neurological, cardiovascular, and other disorders is discussed. Treatment modalities using precise dosages of selected phenolic compounds are outlined to provide clinicians with an effective means of therapy. The author also shares his own experience and personal findings based on 20 years of research, including his recommendations for therapy.

Leaders today are familiar with the demand that they come forward with a new vision. But it is not a matter of fabricating a new vision out of whole cloth. A vision relevant for us today will build on values deeply embedded in human history and in our own tradition. It is not as though we come to the task unready. Men and women from the beginning of history have groped and struggled for various pieces of the answer. The materials out of which we build the vision will be the moral strivings of the species, today and in the distant past.

Most of the ingredients of a vision for this country have been with us for a long time. As the poet wrote, "The light we sought is shining still." That we have failed and fumbled in some of our attempts to achieve our ideals is obvious. But the great ideas still beckon—freedom, equality, justice, the release of human possibilities. The vision is to live up to the best in our past and to reach the goals we have yet to achieve—with respect to our domestic problems and our responsibilities worldwide.

—From the Preface to On Leadership

This book offers interpretations of the work of specific moral philosophers that can be used to present a challenge to what the author have been calling the view of moral philosophy. It focuses on interpreting women moral philosophers and discusses whether women have "prudence" or "natural sense".

Electronic Noses and Olfaction 2000 reflects the state of progress toward the development and application of electronic instruments called electronic noses (e-noses). These instruments are generally based on arrays of sensors for volatile chemicals with broadly tuned selectivity, coupled to appropriate pattern recognition systems. They are capable of detecting and discriminating a number of different simple and complex odors, such as the headspace of coffee and olive oil, as well as being able to perform simple multicomponent gas analysis.
Written by international scientists, engineers, technologists, clinicians, investigators, and instrument manufacturers working in the applied research of e-noses as well as in the applications of olfaction and taste, this volume is essential reading for anyone who wants a review of the latest developments in odor sensors, instrumentation and signal processing, and their medical, agricultural, and food-related applications.

Leading in the Belly of the Beast is an anthology of essays from transformational school leaders around the country who lead in a school system that is not set up for the success of their students, namely students of color and students living in poverty. The book highlights leaders who begin from the premise that the institution of school/system of education in the United States, since its inception, has been established to maintain the racial, cultural, and economic status quo - and to maintain divisions among these racial, cultural, and class groups. These leaders use this very assertion as a foundation for their transformational leadership from within the system. Leading in the Belly of the Beast includes the voices of nine educators in a variety of positions of school leadership, from principals and deans to teacher leaders. The unifying experience of these leaders is that they all currently work in the context of a school and, therefore, have authentic and fresh experiences and expertise to share. The goal of Leading in the Belly of the Beast is to emphasize the need to understand that our current system of education as not broken but as functioning to achieve exactly the results it was designed to achieve, and then to demonstrate why and how transformative leaders can and must achieve different results for students of color and students living in poverty, even while operating in the "belly of the beast".

Leading in the Belly of the Beast is an anthology of essays from transformational school leaders around the country who lead in a school system that is not set up for the success of their students, namely students of color and students living in poverty. The book highlights leaders who begin from the premise that the institution of school/system of education in the United States, since its inception, has been established to maintain the racial, cultural, and economic status quo - and to maintain divisions among these racial, cultural, and class groups. These leaders use this very assertion as a foundation for their transformational leadership from within the system. Leading in the Belly of the Beast includes the voices of nine educators in a variety of positions of school leadership, from principals and deans to teacher leaders. The unifying experience of these leaders is that they all currently work in the context of a school and, therefore, have authentic and fresh experiences and expertise to share. The goal of Leading in the Belly of the Beast is to emphasize the need to understand that our current system of education as not broken but as functioning to achieve exactly the results it was designed to achieve, and then to demonstrate why and how transformative leaders can and must achieve different results for students of color and students living in poverty, even while operating in the "belly of the beast".

Closer to Dylan Thomas than Matthew Arnold in his 'creative violence' and insistence on the sound of poetry, Gerard Manley Hopkins was no staid, conventional Victorian. On entering the Society of Jesus at the age of twenty-four, he burnt all his poetry and 'resolved to write no more, as not belonging to my profession, unless by the wishes of my superiors'. The poems, letters and journal entries selected for this edition were written in the following twenty years of his life, and published posthumously in 1918. His verse is wrought from the creative tensions and paradoxes of a poet-priest who wanted to evoke the spiritual essence of nature sensuously, and to communicate this revelation in natural language and speech-rhythms while using condensed, innovative diction and all the skills of poetic artifice. Intense, vital, individual, his writing is the 'terrible crystal' through which the soul, the inscape, the nature of things, may be illuminated.

Studies on Retinal and Choroidal Disorders examines the role that oxidative and nitrosative stress plays in the complex physiology and pathophysiology of the retina and choroid. Both the basic science researcher and the clinical practitioner can use this book as a guide to the current understanding of retinal and choroidal cellular mechanisms involved in aging and disease. Beginning with a review of oxidative stress and inflammation in the pathoetiology of AMD and a review of the complement system in the retina, the book then takes a detailed look at oxidative stress in lipid metabolism and oxidized lipoproteins in the retina. It examines the anti-apoptotic activity of -crystallins in the presence of glutathione, oxidative stress in the mitochondria and endoplasmic reticulum, the role of iron in retinal disease, the mechanisms of pathological VEGF expression, NAPDH oxidase mechanisms, and Hepatocyte Growth Factor in oxidative stress in the retina. A detailed look at the Ccl2-/-/Cx3cr1-/- mouse model of AMD follows. Then a detailed examination of the systemic changes in AMD is followed by a discussion of cerium oxide nanoparticle reduction of oxidative stress. Two chapters discuss progenitor cells in the cause and treatment of retinal diseases including AMD and diabetic retinopathy. Natural compounds in the prevention and treatment of retinal diseases are exhaustively presented, followed by a chapter on serotonin 5-HT1A receptor agonists in oxidative stress of the retina. The current anti-VEGF treatment strategies of neovascular AMD are then given. The volume continues with a detailed look at nitric oxide and inducible nitric oxide synthase in retinal vascular disease, an explanation of an in vivo technique of studying the effect of lipid hydroperoxides on circulating leucocytes in the retina, an excellent review of oxidative stress in retinopathy of prematurity, and a look at VEGF induced oxidative stress in the retinal ganglion cell. The book ends with a detail examination of the role of carotenoids in retinal health and disease. These 31 chapters summarize what is known about oxidative stress in retinal and choroidal disorders. All those involved with degenerative diseases of the eye will find Studies on Retinal and Choroidal Disorders to be illuminating and comprehensive.

The German attack on merchant shipping in the Second World War, known as the Battle of the Atlantic, was countered partly by code-breaking intelligence known as Ultra. The dramatic revelation of this factor in the middle 1970s resulted in many works giving this as the most important cause of Allied success.

This book aims to discuss the basic principles of an electronic nose, and to provide an account of recent developments in this field, with practical examples of its application. It seeks to review the field together with the many new developments that have occurred since the first meeting was held on electronic noses in Iceland in 1991. It will be essential reading for anyone who is working, researching or simply interested in electronic noses or machine olfaction. A comprehensive appendix is provided at the end of the book.

An exciting contribution to the field, Visual Dysfunction in Diabetes: The Science of Patient Impairment and Improvement is designed with two overriding objectives: to help readers understand the impact of vision impairment in people living daily with diabetes rather than considering diabetic retinopathy solely as a medical problem, and to explore what we know and don't know about the ways diabetes affect the eye. With the plethora of new information being generated, there are still a series of fundamental questions that must be addressed if effective treatments for diabetic retinopathy are to be found and applied. Developed by a renowned group of authorities, Visual Dysfunction in Diabetes: The Science of Patient Impairment and Improvement offers responses and context for a range of questions, such as: do metabolic factors beyond glucose contribute to vision-threatening diabetic retinopathy? If so, how do these lead to vision impairment? Is diabetic retinopathy a response to systemic metabolic abnormalities or are there unique ocular problems related to insulin resistance? What is the relationship between the neural, vascular, and inflammatory abnormalities in diabetic retinopathy? Do they represent a pathological cascade induced sequentially or simultaneous responses to one or more metabolic perturbations? The authors note that if we do not address these types of questions, it is possible that the long process of developing new therapeutic s will target only one arm of the pathology and leave the retina open to damaging consequences of the others. State-of-the-art, comprehensive, and an invaluable addition the research and clinical literature, Visual Dysfunction in Diabetes: The Science of Patient Impairment and Improvement offers guidance and a significant step toward new scientific approaches that can lessen the devastating vision impairment associated with diabetes.