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Impact of Genetic Targets on Cancer Therapy (Hardcover, 2013 ed.): Wafik S ElDeiry Impact of Genetic Targets on Cancer Therapy (Hardcover, 2013 ed.)
Wafik S ElDeiry
R6,881 Discovery Miles 68 810 Ships in 12 - 19 working days

The volume provides a forum for original peer-reviewed short communications, full-length research and review articles on new research findings and developments on the topic of genetic targets on cancer therapies. As the field is highly important it requires co-operation between research communities from all over the world to share their knowledge and experience in order to move the field forward. Each chapter includes a discussion of the impact of the tumor microenvironment and cancer stem cells and cover current knowledge in this area as it pertains to the disease, including emerging therapy targeting the microenvironment and/or cancer stem cells.

Tumor Suppressor Genes - Volume 2: Regulation, Function, and Medicinal Applications (Hardcover, 2003 ed.): Wafik S ElDeiry Tumor Suppressor Genes - Volume 2: Regulation, Function, and Medicinal Applications (Hardcover, 2003 ed.)
Wafik S ElDeiry
R4,798 Discovery Miles 47 980 Ships in 12 - 19 working days

It has become clear that tumors result from excessive cell proliferation and a corresponding reduction in cell death caused by the successive accumulation of mutations in key regulatory target genes over time. During the 1980s, a number of oncogenes were characterized, whereas from the 1990s to the present, the emp- sis has shifted to tumor suppressor genes (TSGs). It has become clear that oncogenes and TSGs function in the same pathways, providing positive and negative growth regulatory activities. The signaling pathways controlled by these genes involve virtually every process in cell biology, including nuclear events, cell cycle, cell death, cytoskeletal, cell membrane, angiogenesis, and cell adhesion effects. Mu- tions in tumor suppressor genes have been identified in familial cancer syndromes, and the same genes in many cases have been found to be mutationally inactivated in sporadically occurring cancers. In their normal state, TSGs control cancer development and progression, as well as contribute to the sensitivity of cancers to a variety of therapeutics. Understanding the classes of TSGs, the biochemical pa- ways they function in, and how they are regulated provides an essential lesson in cancer biology. We cannot hope to advance our current knowledge and to develop new and more effective therapies without understanding the relevant pathways and how they influence the present approaches to therapy. Moreover, it is important to be able to access not only the powerful tools now available to discover these genes, but also their links to cell biology and growth control.

Tumor Suppressor Genes - Volume 1: Pathways and Isolation Strategies (Hardcover, 2nd Revised edition): Wafik S ElDeiry Tumor Suppressor Genes - Volume 1: Pathways and Isolation Strategies (Hardcover, 2nd Revised edition)
Wafik S ElDeiry
R4,484 Discovery Miles 44 840 Ships in 10 - 15 working days

It has become clear that tumors arise from excessive cell proliferation and a c- responding reduction in cell death. Tumors result from the successive accumulation of mutations in key regulatory target genes over time. During the 1980s, a number of oncogenes were characterized, whereas from the 1990s to the present, the emphasis shifted to tumor suppressor genes (TSGs). It has become clear that oncogenes and tumor suppressor genes function in the same pathways, providing positive and ne- tive growth regulatory activities. The signaling pathways controlled by these genes involve virtually every process in cell biology, including nuclear events, cell cycle, cell death, cytoskeletal, cell membrane, angiogenesis, and cell adhesion effects. Tumor suppressor genes are mutated in hereditary cancer syndromes, as well as somatically in nonhereditary cancers. In their normal state, TSGs control cancer development and p- gression, as well as contribute to the sensitivity of cancers to a variety of therapeutics. Understanding the classes of TSGs, the biochemical pathways they function in, and how they are regulated provides an essential lesson in cancer biology. We cannot hope to advance our current knowledge and to develop new and more effective therapies without understanding the relevant pathways and how they influence the present approaches to therapy. Moreover, it is important to be able to access the powerful tools now available to discover these genes, as well as their links to cell biology and growth control.

Death Receptors in Cancer Therapy (Hardcover, 2005 ed.): Wafik S ElDeiry Death Receptors in Cancer Therapy (Hardcover, 2005 ed.)
Wafik S ElDeiry
R4,644 Discovery Miles 46 440 Ships in 10 - 15 working days

An in depth review of our latest understanding of the molecular events that regulate cell death and those molecules that provide targets for developing agonists or antagonists to modulate death signaling for therapeutic purposes. The authors focus on the extrinsic system of death receptors, their regulation and function, and their abnormalities in cancer. Topics of particular interest include resistance to apoptosis, TRAIL signaling, death receptors in embryonic development, mechanisms of caspase activation, and death receptor mutations in cancer. Additional chapters address death signaling in melanoma, synthetic retinoids and death receptors, the role of p53 in death receptor regulation, immune suppression of cancer, and combination therapy with death ligands.

Impact of Genetic Targets on Cancer Therapy (Paperback, 2013 ed.): Wafik S ElDeiry Impact of Genetic Targets on Cancer Therapy (Paperback, 2013 ed.)
Wafik S ElDeiry
R6,834 Discovery Miles 68 340 Ships in 10 - 15 working days

The volume provides a forum for original peer-reviewed short communications, full-length research and review articles on new research findings and developments on the topic of genetic targets on cancer therapies. As the field is highly important it requires co-operation between research communities from all over the world to share their knowledge and experience in order to move the field forward. Each chapter includes a discussion of the impact of the tumor microenvironment and cancer stem cells and cover current knowledge in this area as it pertains to the disease, including emerging therapy targeting the microenvironment and/or cancer stem cells.

Tumor Suppressor Genes - Volume 2: Regulation, Function, and Medicinal Applications (Paperback, Softcover reprint of the... Tumor Suppressor Genes - Volume 2: Regulation, Function, and Medicinal Applications (Paperback, Softcover reprint of the original 1st ed. 2003)
Wafik S ElDeiry
R3,280 Discovery Miles 32 800 Ships in 10 - 15 working days

It has become clear that tumors result from excessive cell proliferation and a corresponding reduction in cell death caused by the successive accumulation of mutations in key regulatory target genes over time. During the 1980s, a number of oncogenes were characterized, whereas from the 1990s to the present, the emp- sis has shifted to tumor suppressor genes (TSGs). It has become clear that oncogenes and TSGs function in the same pathways, providing positive and negative growth regulatory activities. The signaling pathways controlled by these genes involve virtually every process in cell biology, including nuclear events, cell cycle, cell death, cytoskeletal, cell membrane, angiogenesis, and cell adhesion effects. Mu- tions in tumor suppressor genes have been identified in familial cancer syndromes, and the same genes in many cases have been found to be mutationally inactivated in sporadically occurring cancers. In their normal state, TSGs control cancer development and progression, as well as contribute to the sensitivity of cancers to a variety of therapeutics. Understanding the classes of TSGs, the biochemical pa- ways they function in, and how they are regulated provides an essential lesson in cancer biology. We cannot hope to advance our current knowledge and to develop new and more effective therapies without understanding the relevant pathways and how they influence the present approaches to therapy. Moreover, it is important to be able to access not only the powerful tools now available to discover these genes, but also their links to cell biology and growth control.

Death Receptors in Cancer Therapy (Paperback, Softcover reprint of hardcover 1st ed. 2005): Wafik S ElDeiry Death Receptors in Cancer Therapy (Paperback, Softcover reprint of hardcover 1st ed. 2005)
Wafik S ElDeiry
R3,175 Discovery Miles 31 750 Ships in 10 - 15 working days

An in depth review of our latest understanding of the molecular events that regulate cell death and those molecules that provide targets for developing agonists or antagonists to modulate death signaling for therapeutic purposes. The authors focus on the extrinsic system of death receptors, their regulation and function, and their abnormalities in cancer. Topics of particular interest include resistance to apoptosis, TRAIL signaling, death receptors in embryonic development, mechanisms of caspase activation, and death receptor mutations in cancer. Additional chapters address death signaling in melanoma, synthetic retinoids and death receptors, the role of p53 in death receptor regulation, immune suppression of cancer, and combination therapy with death ligands.

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