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Books > Science & Mathematics > Biology, life sciences > Cellular biology
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Tumor Suppressor Genes - Volume 1: Pathways and Isolation Strategies (Hardcover, 2nd Revised edition)
Loot Price: R4,309
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Tumor Suppressor Genes - Volume 1: Pathways and Isolation Strategies (Hardcover, 2nd Revised edition)
Series: Methods in Molecular Biology, 222
Expected to ship within 12 - 17 working days
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It has become clear that tumors arise from excessive cell
proliferation and a c- responding reduction in cell death. Tumors
result from the successive accumulation of mutations in key
regulatory target genes over time. During the 1980s, a number of
oncogenes were characterized, whereas from the 1990s to the
present, the emphasis shifted to tumor suppressor genes (TSGs). It
has become clear that oncogenes and tumor suppressor genes function
in the same pathways, providing positive and ne- tive growth
regulatory activities. The signaling pathways controlled by these
genes involve virtually every process in cell biology, including
nuclear events, cell cycle, cell death, cytoskeletal, cell
membrane, angiogenesis, and cell adhesion effects. Tumor suppressor
genes are mutated in hereditary cancer syndromes, as well as
somatically in nonhereditary cancers. In their normal state, TSGs
control cancer development and p- gression, as well as contribute
to the sensitivity of cancers to a variety of therapeutics.
Understanding the classes of TSGs, the biochemical pathways they
function in, and how they are regulated provides an essential
lesson in cancer biology. We cannot hope to advance our current
knowledge and to develop new and more effective therapies without
understanding the relevant pathways and how they influence the
present approaches to therapy. Moreover, it is important to be able
to access the powerful tools now available to discover these genes,
as well as their links to cell biology and growth control.
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