An in depth review of our latest understanding of the molecular
events that regulate cell death and those molecules that provide
targets for developing agonists or antagonists to modulate death
signaling for therapeutic purposes. The authors focus on the
extrinsic system of death receptors, their regulation and function,
and their abnormalities in cancer. Topics of particular interest
include resistance to apoptosis, TRAIL signaling, death receptors
in embryonic development, mechanisms of caspase activation, and
death receptor mutations in cancer. Additional chapters address
death signaling in melanoma, synthetic retinoids and death
receptors, the role of p53 in death receptor regulation, immune
suppression of cancer, and combination therapy with death ligands.
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