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Tumor Suppressor Genes - Volume 2: Regulation, Function, and Medicinal Applications (Hardcover, 2003 ed.)
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Tumor Suppressor Genes - Volume 2: Regulation, Function, and Medicinal Applications (Hardcover, 2003 ed.)
Series: Methods in Molecular Biology, 223
Expected to ship within 12 - 17 working days
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It has become clear that tumors result from excessive cell
proliferation and a corresponding reduction in cell death caused by
the successive accumulation of mutations in key regulatory target
genes over time. During the 1980s, a number of oncogenes were
characterized, whereas from the 1990s to the present, the emp- sis
has shifted to tumor suppressor genes (TSGs). It has become clear
that oncogenes and TSGs function in the same pathways, providing
positive and negative growth regulatory activities. The signaling
pathways controlled by these genes involve virtually every process
in cell biology, including nuclear events, cell cycle, cell death,
cytoskeletal, cell membrane, angiogenesis, and cell adhesion
effects. Mu- tions in tumor suppressor genes have been identified
in familial cancer syndromes, and the same genes in many cases have
been found to be mutationally inactivated in sporadically occurring
cancers. In their normal state, TSGs control cancer development and
progression, as well as contribute to the sensitivity of cancers to
a variety of therapeutics. Understanding the classes of TSGs, the
biochemical pa- ways they function in, and how they are regulated
provides an essential lesson in cancer biology. We cannot hope to
advance our current knowledge and to develop new and more effective
therapies without understanding the relevant pathways and how they
influence the present approaches to therapy. Moreover, it is
important to be able to access not only the powerful tools now
available to discover these genes, but also their links to cell
biology and growth control.
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