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Find out where our world is headed with this dazzling first-hand account of inventing the future from the #1 New York Times bestselling author of What Should I Do With My Life? and the founder of science accelerator IndieBio. Decoding the World is a buddy adventure about the quest to live meaningfully in a world with such uncertainty. It starts with Po Bronson coming to IndieBio. Arvind Gupta created IndieBio as a laboratory for early biotech startups trying to solve major world problems. Glaciers melting. Dying bees. Infertility. Cancer. Ocean plastic. Pandemics. Arvind is the fearless one, a radical experimentalist. Po is the studious detective, patiently synthesizing clues others have missed. Their styles mix and create a quadratic speedup of creativity. Yin and Yang crystallized. As they travel around the world, finding scientists to join their cause, the authors bring their firsthand experience to the great mysteries that haunt our future. Natural resource depletion. Job-taking robots. China's global influence. Arvind feels he needs to leave IndieBio to help startups do more than just get started. But as his departure draws near, he struggles to leave the sanctum he created. While Po has to prove he can keep the "indie" in IndieBio after Arvind is gone. After looking through their lens, you'll never see the world the same.
For courses in Microbiology Lab and Nursing and Allied Health Microbiology Lab A Flexible Approach to the Modern Microbiology Lab Easy to adapt for almost any microbiology lab course, this versatile, comprehensive, and clearly written manual is competitively priced and can be paired with any undergraduate microbiology text. Known for its thorough coverage, straightforward procedures, and minimal equipment requirements, the Eleventh Edition incorporates current safety protocols from governing bodies such as the EPA, ASM, and AOAC. The new edition also includes alternate organisms for experiments for easy customization in Biosafety Level 1 and 2 labs. New lab exercises have been added on Food Safety and revised experiments, and include options for alternate media, making the experiments affordable and accessible to all lab programs. Ample introductory material, engaging clinical applications, and laboratory safety instructions are provided for each experiment along with easy-to-follow procedures and flexible lab reports with review and critical thinking questions.
A comprehensive laboratory manual containing 39 experiments that parallel the text, including a final group of six experiments on qualitative cation analysis.
Responding to the developments of the past twenty years, Les Kirkup has thoroughly updated his popular book on experimental methods, while retaining the extensive coverage and practical advice from the first edition. Many topics from that edition remain, including keeping a record of work, how to deal with measurement uncertainties, understanding the statistical basis of data analysis and reporting the results of experiments. However, with new technologies influencing how experiments are devised, carried out, analyzed, presented and reported, this new edition reflects the digital changes which have taken place and the increased emphasis on the importance of communication skills in reporting results. Bringing together key elements of experimental methods into one coherent book, it is perfect for students seeking guidance with their experimental work, including how to acquire, analyse and present data. Exercises, worked examples and end-of-chapter problems are provided throughout the book to reinforce fundamental principles.
The definitive guide to the principles and practice of experimental organic chemistry - fully updated and now featuring more than 100 experiments The latest edition of this popular guide to experimental organic chemistry takes students from their first day in the laboratory right through to complex research procedures. All sections have been updated to reflect new techniques, equipment and technologies, and the text has been revised with an even sharper focus on practical skills and procedures. The first half of the book is devoted to safe laboratory practice as well as purification and analytical techniques; particularly spectroscopic analysis. The second half contains step-by-step experimental procedures, each one illustrating a basic principle, or important reaction type. Tried and tested over almost three decades, over 100 validated experiments are graded according to their complexity and all are chosen to highlight important chemical transformations and to teach key experimental skills. New sections cover updated health and safety guidelines, additional spectroscopic techniques, electronic notebooks and record keeping, and techniques, such as semi-automated chromatography and enabling technologies such as the use of microwave and flow chemistry. New experiments include transition metal-catalysed cross-coupling, organocatalysis, asymmetric synthesis, flow chemistry, and microwave-assisted synthesis. Key aspects of this third edition include: * Detailed descriptions of the correct use of common apparatus used in the organic laboratory * Outlines of practical skills that all chemistry students must learn * Highlights of aspects of health and safety in the laboratory, both in the first section and throughout the experimental procedures * Four new sections reflecting advances in techniques and technologies, from electronic databases and information retrieval to semi-automated chromatography * More than 100 validated experiments of graded complexity from introductory to research level * A user-friendly experiment directory * An instructor manual and PowerPoint slides of the figures in the book available on a companion website A comprehensive guide to contemporary organic chemistry laboratory principles, procedures, protocols, tools and techniques, Experimental Organic Chemistry, Third Edition is both an essential laboratory textbook for students of chemistry at all levels, and a handy bench reference for experienced chemists.
By illustrating a wide range of specific applications in all major industries, this work broadens the coverage of X-ray diffraction beyond basic tenets, research and academic principles. The book serves as a guide to solving problems faced everyday in the laboratory, and offers a review of the current theory and practice of X-ray diffraction, major advances and potential uses.
This research-level reference provides a review of the morphological techniques that have become a primary method of anatomical study correlating structure and function in lung physiology and pathology. Detailing the evolution of anatomy as a research discipline, it explores general structural techn
This unique, practical, pocket-sized guide and reference provides every first year bioscience student with all they need to know to prepare reagents correctly and perform fundamental laboratory techniques. It also helps them to analyse their data and present their findings, in addition to directing the reader, via a comprehensive list of references, to relevant further reading
All of the core bioscience laboratory techniques are covered including: basic calculations and the preparation of solutions; aseptic techniques; microscopy techniques; cell fractionation; spectrophotometry; chromatography of small and large molecules: electrophoresis of proteins and nucleic acids and data analysis. In addition the book includes clear, relevant diagrams and worked examples of calculations.
In short, this is a 'must-have' for all first year bioscience students struggling to get to grips with this vitally important element of their course.
The first volume in the new Cambridge Handbooks in Behavioral Genetics series, Behavioral Genetics of the Mouse provides baseline information on normal behaviors, essential in both the design of experiments using genetically modified or pharmacologically treated animals and in the interpretation and analyses of the results obtained. The book offers a comprehensive overview of the genetics of naturally occurring variation in mouse behavior, from perception and spontaneous behaviors such as exploration, aggression, social interactions and motor behaviors, to reinforced behaviors such as the different types of learning. Also included are numerous examples of potential experimental problems, which will aid and guide researchers trying to troubleshoot their own studies. A lasting reference, the thorough and comprehensive reviews offer an easy entrance into the extensive literature in this field, and will prove invaluable to students and specialists alike.
How do scientists impact society in the twenty-first century? Many scientists are increasingly interested in the impact that their research will have on the public. Scientists likewise must answer the question above when applying for funding from government agencies, particularly as part of the 'Broader Impacts' criterion of proposals to the US National Science Foundation. This book equips scientists in all disciplines to do just that, by providing an overview of the origins, history, rationale, examples, and case studies of broader impacts, primarily drawn from the author's experiences over the past five decades. Beyond including theory and evidence, it serves as a 'how to' guide for best practices for scientists. Although this book primarily uses examples from the NSF, the themes and best practices are applicable to scientists and applications around the world where funding also requires impacts and activities that benefit society.
Specifically intended for lab-based biomedical researchers, this practical guide shows how to design experiments that are reproducible, with low bias, high precision, and widely applicable results. With specific examples from research using both cell cultures and model organisms, it explores key ideas in experimental design, assesses common designs, and shows how to plan a successful experiment. It demonstrates how to control biological and technical factors that can introduce bias or add noise, and covers rarely discussed topics such as graphical data exploration, choosing outcome variables, data quality control checks, and data pre-processing. It also shows how to use R for analysis, and is designed for those with no prior experience. An accompanying website (https://stanlazic.github.io/EDLB.html) includes all R code, data sets, and the labstats R package. This is an ideal guide for anyone conducting lab-based biological research, from students to principle investigators working in either academia or industry.
"Essential Laboratory Skills for Biosciences" is an essential companion during laboratory sessions. It is designed to be simple and give clear step by step instructions on essential techniques, supported by relevant diagrams. The book includes the use of particular equipment and how to do simple calculations that students come across regularly in laboratory practicals.
Written by experienced lecturers this handy pocket book provides: Simple to follow laboratory techniquesClear use of diagrams and illustrations to explain techniques, procedures and equipmentStep by step worked out examples of calculations including concentrations, dilutions and molarity
Suitable for all first year university students, the techniques in the book will also be useful for postgraduate and final year project students and enhance the practical and theoretical knowledge of all those studying bioscience related subjects.
A revealing and provocative look at the current state of global science We take the advance of science as given. But how does science really work? Is it truly as healthy as we tend to think? How does the system itself shape what scientists do? The Secret Life of Science takes a clear-eyed and provocative look at the current state of global science, shedding light on a cutthroat and tightly tensioned enterprise that even scientists themselves often don't fully understand. The Secret Life of Science is a dispatch from the front lines of modern science. It paints a startling picture of a complex scientific ecosystem that has become the most competitive free-market environment on the planet. It reveals how big this ecosystem really is, what motivates its participants, and who reaps the rewards. Are there too few scientists in the world or too many? Are some fields expanding at the expense of others? What science is shared or published, and who determines what the public gets to hear about? What is the future of science? Answering these and other questions, this controversial book explains why globalization is not necessarily good for science, nor is the continued growth in the number of scientists. It portrays a scientific community engaged in a race for limited resources that determines whether careers are lost or won, whose research visions become the mainstream, and whose vested interests end up in control. The Secret Life of Science explains why this hypercompetitive environment is stifling the diversity of research and the resiliency of science itself, and why new ideas are needed to ensure that the scientific enterprise remains healthy and vibrant.
Well-structured and adopting a pedagogical approach, this self-contained monograph covers the fundamentals of scanning probe microscopy, showing how to use the techniques for investigating physical and chemical properties on the nanoscale and how they can be used for a wide range of soft materials. It concludes with a section on the latest techniques in nanomanipulation and patterning. This first book to focus on the applications is a must-have for both newcomers and established researchers using scanning probe microscopy in soft matter research. From the contents: * Atomic Force Microscopy and Other Advanced Imaging Modes * Probing of Mechanical, Thermal Chemical and Electrical Properties * Amorphous, Poorly Ordered and Organized Polymeric Materials * Langmuir-Blodgett and Layer-by-Layer Structures * Multi-Component Polymer Systems and Fibers * Colloids and Microcapsules * Biomaterials and Biological Structures * Nanolithography with Intrusive AFM Tipand Dip-Pen Nanolithography * Microcantilever-Based Sensors
This textbook helps you to prepare for your next exams and practical courses by combining theory with virtual lab simulations. The "Labster Virtual Lab Experiments" series gives you a unique opportunity to apply your newly acquired knowledge in a learning game that simulates exciting laboratory experiments. Try out different techniques and work with machines that you otherwise wouldn't have access to.In this book, you'll learn the fundamental concepts of basic biochemistry focusing on: Ionic and Covalent Bonds Introduction to Biological Macromolecules Carbohydrates Enzyme Kinetics In each chapter, you'll be introduced to one virtual lab simulation and a true-to-life challenge. Following a theory section, you'll be able to play the relevant simulation that includes quiz questions to reinforce your understanding of the covered topics. 3D animations will show you molecular processes not otherwise visible to the human eye. If you have purchased a printed copy of this book, you get free access to five simulations for the duration of six months. If you're using the e-book version, you can sign up and buy access to the simulations at www.labster.com/springer. If you like this book, try out other topics in this series, including "Basic Biology", "Basic Genetics", and "Genetics of Human Diseases". Please note that the simulations in the book are not virtual reality (VR) but 2D virtual experiments.
Microscopy plays an integral role in the research and development of new medicines. Pharmaceutical Microscopy describes a wide variety of techniques together with numerous practical applications of importance in drug development. The first section presents general methods and applications with an emphasis on the physical science aspects. Techniques covered include optical crystallography, thermal microscopy, scanning electron microscopy, energy dispersive x-ray spectrometry, microspectroscopy (infrared and Raman), and particle size and shape by image analysis. The second section presents applications of these techniques to specific topics of pharmaceutical interest, including studies of polymorphism, particle size and shape analysis, and contaminant identification. Pharmaceutical Microscopy is designed for those scientists who must use these techniques to solve pharmaceutical problems but do not need to become expert microscopists. Consequently, each section has exercises designed to teach the reader how to use and apply the techniques in the book. Although the focus is on pharmaceutical development, workers in other fields such as food science and organic chemistry will also benefit from the discussion of techniques and the exercises. Provides comprehensive coverage of key microscopy techniques used in pharmaceutical development Helps the reader to solve specific problems in pharmaceutical quality assurance Oriented and designed for pharmaceutical scientists who need to use microscopy but are not expert microscopists Includes a large number of practical exercises to give the reader hands-on experience with the techniques Written by an author with 21 years of experience in the pharmaceutical industry
This open access book provides a comprehensive overview of the application of the newest laser and microscope/ophthalmoscope technology in the field of high resolution imaging in microscopy and ophthalmology. Starting by describing High-Resolution 3D Light Microscopy with STED and RESOLFT, the book goes on to cover retinal and anterior segment imaging and image-guided treatment and also discusses the development of adaptive optics in vision science and ophthalmology. Using an interdisciplinary approach, the reader will learn about the latest developments and most up to date technology in the field and how these translate to a medical setting. High Resolution Imaging in Microscopy and Ophthalmology - New Frontiers in Biomedical Optics has been written by leading experts in the field and offers insights on engineering, biology, and medicine, thus being a valuable addition for scientists, engineers, and clinicians with technical and medical interest who would like to understand the equipment, the applications and the medical/biological background. Lastly, this book is dedicated to the memory of Dr. Gerhard Zinser, co-founder of Heidelberg Engineering GmbH, a scientist, a husband, a brother, a colleague, and a friend.
The third edition of this volume focuses on experimental models that are useful for investigating various aspects of cytoskeleton structure and function. Animal, plant, protist, and fungal models highlight twenty-four chapters that provide detailed protocols for live and fixed-cell imaging, dynamics of cytoskeleton components, cell and organelle motility, and genetics and proteomics. Written in the highly successful Methods in Molecular Biology series format, protocols in each chapter are up-to-date menus organized in a useful step-by-step format appropriate for novice and established investigators. Each chapter is equipped with a valuable notes section that provides a troubleshooting guide and helpful, and often unpublished, technical information aimed at ensuring success with implementation of the protocols. Authoritative and thorough, Cytoskeleton Methods and Protocols, Third Edition helps researchers expand their understanding of cytoskeleton structure and function.
This book is about China's ambitions in its most complex and internationally visible space endeavor, namely its human space exploration programme. It provides a comprehensive reflection on Chinas strategic direction and objectives in space, including in particular those set forth in its human spaceflight programme and analyses the key domestic and external factors affecting the country's presumed manned lunar ambitions. The objective of the book is to disentangle the opportunities and challenges Chinas space ambitions are creating for other spacefaring nations and for Europe in particular. It therefore includes an in-depth analysis of possible European postures towards China in space exploration and seeks to stimulate a debate on future space strategies in the broader context of world politics.
Since its discovery, Atomic Force Microscopy (AFM) has become a technique of choice for non-destructive surface characterization with sub-molecular resolution. The AFM has also emerged as a problem-solving tool in applications relevant to particle-solid and particle-liquid interactions, design, fabrication, and characterization of new materials, and development of new technologies for processing and modification of materials. This volume is a comprehensive review of AFM techniques and their application in adhesion studies. It is intended for both researchers and students in engineering disciplines, physics and biology. Over 100 authors contributed to this book, summarizing current status of research on measurements of colloidal particle-solid adhesion and molecular forces, solid surface imaging and mapping, and discussing the contact mechanics models applicable to particle-substrate and particle-particle systems.
The first book on the topic, with each chapter written by pioneers in the field, this essential resource details the fundamental theory, applications, and future developments of liquid cell electron microscopy. This book describes the techniques that have been developed to image liquids in both transmission and scanning electron microscopes, including general strategies for examining liquids, closed and open cell electron microscopy, experimental design, resolution, and electron beam effects. A wealth of practical guidance is provided, and applications are described in areas such as electrochemistry, corrosion and batteries, nanocrystal growth, biomineralization, biomaterials and biological processes, beam-induced processing, and fluid physics. The book also looks ahead to the future development of the technique, discussing technical advances that will enable higher resolution, analytical microscopy, and even holography of liquid samples. This is essential reading for researchers and practitioners alike.
This fully updated, self-contained textbook covering modern optical microscopy equips students with a solid understanding of the theory underlying a range of advanced techniques. Two new chapters cover pump-probe techniques, and imaging in scattering media, and additional material throughout covers light-sheet microscopy, image scanning microscopy, and much more. An array of practical techniques are discussed, from classical phase contrast and confocal microscopy, to holographic, structured illumination, multi-photon, and coherent Raman microscopy, and optical coherence tomography. Fundamental topics are also covered, including Fourier optics, partial coherence, 3D imaging theory, statistical optics, and the physics of scattering and fluorescence. With a wealth of end-of-chapter problems, and a solutions manual for instructors available online, this is an invaluable book for electrical engineering, biomedical engineering, and physics students taking graduate courses on optical microscopy, as well as advanced undergraduates, professionals, and researchers looking for an accessible introduction to the field.
Team leaders should be full of ideas for new research projects and inspire a research group to achieve great results. This practical guide for team leaders, and those who aspire to become team leader, offers a unique approach to help readers develop research and become a more independent and productive investigator. Readers can learn how to recruit and develop talented team members, how to negotiate contracts and manage projects, and how to create wider visibility and publicity for their science. From human resources and project finances, legal affairs and knowledge transfer to public engagement and media performance, the book provides guidance to enhance skills and combine them with those of support staff on the road to success. With numerous valuable tips, real-life stories and practical exercises, this must-read guide provides everything needed to take responsibility for leading research teams. This title is available as Open Access via Cambridge Core.
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