The detection and measurement of the dynamic regulation and interactions of cells and proteins within the living cell are critical to the understanding of cellular biology and pathophysiology. The multidisciplinary field of molecular imaging of living subjects continues to expand with dramatic advances in chemistry, molecular biology, therapeutics, engineering, medical physics and biomedical applications. Molecular Imaging: Principles and Practice, Volumes 1 and 2, Second Edition provides the first point of entry for physicians, scientists, and practitioners. This authoritative reference book provides a comprehensible overview along with in-depth presentation of molecular imaging concepts, technologies and applications making it the foremost source for both established and new investigators, collaborators, students and anyone interested in this exciting and important field.

cryoEM, a new volume in the Methods in Enzymology series, continues the legacy of this premier serial with quality chapters authored by leaders in the field. This volume covers research methods and new developments in recording images, the creation, evaluation and validation of 3D maps from the images, model building into maps and refinement of the resulting atomic structures, and applications of essentially single particle methods to helical structures and to sub-tomogram averaging.

Information literacy-the ability to find, evaluate, and use information resources-is an important skill for future chemists. Students and scientists need to distinguish between information provided by Wikipedia, ChemSpider, research journals, and The New York Times, depending on the intended use of the information sought. Instructors and librarians may often teach these skills through stand-alone database demonstrations, video tutorials, and lectures. However, it is possible to teach these skills in a more contextual and integrated manner by designing chemistry assignments that incorporate information literacy as a learning outcome. This book will prove useful for librarians and chemistry instructors who are designing courses in which students develop information literacy in the context of a chemistry course at two-year colleges, public and private universities, and high schools. The chapters in this book review the current state of information literacy in chemistry and provide concrete examples of assignments and interventions aimed at teaching information literacy skills in chemistry curricula. A wide range of options are offered for integrating information literacy into college-level chemistry courses, including general chemistry, organic chemistry, science courses for students not majoring in science, and chemistry capstone research courses.

Work with individual atoms and molecules aims to demonstrate that miniaturized electronic, optical, magnetic, and mechanical devices can operate ultimately even at the level of a single atom or molecule. As such, atomic and molecular manipulation has played an emblematic role in the development of the field of nanoscience. New methods based on the use of the scanning tunnelling microscope (STM) have been developed to characterize and manipulate all the degrees of freedom of individual atoms and molecules with an unprecedented precision. In the meantime, new concepts have emerged to design molecules and substrates having specific optical, mechanical and electronic functions, thus opening the way to the fabrication of real nano-machines. Manipulation of individual atoms and molecules has also opened up completely new areas of research and knowledge, raising fundamental questions of "Optics at the atomic scale," "Mechanics at the atomic scale," Electronics at the atomic scale," "Quantum physics at the atomic scale," and "Chemistry at the atomic scale." This book aims to illustrate the main aspects of this ongoing scientific adventure and to anticipate the major challenges for the future in "Atomic and molecular manipulation" from fundamental knowledge to the fabrication of atomic-scale devices.
Provides a broad overview of the field to aid those new and entering into this research areaPresents a review of the historical development and evolution of the fieldOffers a clear personalized view of current scanning probe microscopy research from world experts

Compelling evidence exists to support the hypothesis that both formal and informal mentoring practices that provide access to information and resources are effective in promoting career advancement, especially for women. Such associations provide opportunities to improve the status, effectiveness, and visibility of a faculty member via introductions to new colleagues, knowledge of information about the organizational system, and awareness of innovative projects and new challenges.
This volume developed from the symposium "Successful Mentoring Strategies to Facilitate the Advancement of Women Faculty" held at the 239th National Meeting of the American Chemical Society in San Francisco in March 2010. The organizers of the symposium, also serving as the editors of this volume, aimed to feature an array of successful mechanisms for enhancing the leadership, visibility, and recognition of academic women scientists using various mentoring strategies. It was their goal to have contributors share creative approaches to address the challenge of broadening the participation and advancement of women in science and engineering at all career stages and from a wide range of institutional types. Inspired by the successful outcomes of the editors' own NSF-ADVANCE project that involved the formation of horizontal peer mentoring alliances, this book is a collection of valuable practices and insights to both share how their horizontal mentoring strategy has impacted their professional and personal lives and to learn of other effective mechanisms for advancing women faculty.

Collaborations between scientists often transcend borders and cultural differences. The fundamental nature of science allows scientists to communicate using knowledge of their field but the institutions that support them are often hindered by financial and cultural barriers. As a result, science suffers. This book evolved from an August 2009 symposium at the 238th annual meeting of the American Chemical Society in Washington, DC. Its focus is on chemistry students and professors interested in developing a global approach to teaching chemistry, by participating in an international exchange program or incorporating culturally inclusive techniques into their classroom. The book has three broad themes; education research with a globalized perspective, experiences of teaching and learning in different countries, and organizations that support a global view of chemical education and chemistry.

This is the first book to bring together both the basic theory and proven process engineering practice of AFM. It is presented in a way that is accessible and valuable to practising engineers as well as to those who are improving their AFM skills and knowledge, and to researchers who are developing new products and solutions using AFM.

The book takes a rigorous and practical approach that ensures it is directly applicable to process engineering problems. Fundamentals and techniques are concisely described, while specific benefits for process engineering are clearly defined and illustrated. Key content includes: particle-particle, and particle-bubble interactions; characterization of membrane surfaces; the development of fouling resistant membranes; nanoscale pharmaceutical analysis; nanoengineering for cellular sensing; polymers on surfaces; micro and nanoscale rheometry.
Atomic force microscopy (AFM) is an important tool for process engineers and scientists as it enables improved processes and productsThe only book dealing with the theory and practical applications of atomic force microscopy in process engineeringProvides best-practice guidance and experience on using AFM for process and product improvement

This book brings together the latest perspectives and ideas on teaching modern physical chemistry. It includes perspectives from experienced and well-known physical chemists, a thorough review of the education literature pertaining to physical chemistry, a thorough review of advances in undergraduate laboratory experiments from the past decade, in-depth descriptions of using computers to aid student learning, and innovative ideas for teaching the fundamentals of physical chemistry. This book will provide valuable insight and information to all teachers of physical chemistry.

New Publication! Based on years of experience and prior publications, the NEW two-volume book, STEM RESEARCH for STUDENTS, is a vital resource for K-12 teachers, higher education faculty, and their students. In Volume One, students acquire the fundamentals and apply them to their investigations: Conduct experiments and refine the design and procedures; Construct data tables and graphs, use descriptive statistics, and make sense of an experiment; Meet a human need by designing, building, and testing a model; Communicate findings through reports and interactions with peers; Apply mathematical concepts to data including ratio and proportional relationships, geometry and measurement, algebra, and statistics. STEM Research for Students, Volume 1, is: Student friendly! Chapters contain investigations with readily available materials, explanations of major concepts, practice sets, and formative assessment tools. Use as a sequence or as individual units of study for specific content. STEM encompassing! For each core experiment, students have multiple options for making connections to various scientific disciplines, engineering, and mathematics. Teacher enhanced! Each chapter contains learning objectives and assessment tools checklists or rubrics. Answers to the practice sets are available on a secure Kendall Hunt web site. Standards aligned! All chapters are aligned with the Next Generation Science Standards, Common Core Standards for Mathematics and Literacy in Science and Technical Subjects, and the International Standards for Technology in Education Standards for Students. Available in print and e-Book formats, STEM Research for Students, Volume 1, may be used: As a supplemental text in upper elementary, middle, and senior high classrooms; As a core text for introductory research courses and STEM research clubs; For pre-service and in-service teachers of science, mathematics, career and technical courses, and gifted students; As a resource for all teachers involved with experiments, engineering designs, mathematical investigations, and competitive STEM projects. The companion volume, STEM Research for Students, Volume 2 enables students to build upon this strong foundation and create effective science experiments, engineering designs, and mathematical investigations.

New Publication! Based on years of experience and prior publications, the NEW two-volume book, STEM RESEARCH for STUDENTS, is a vital resource for K-12 teachers, higher education faculty, and their students. In Volume Two, students build upon a strong foundation to create original STEM projects: Brainstorm ideas for projects; Analyze and address the safety risks involved in a project; Use the library and Web to expand understanding and develop a valid idea; Conduct a group mini-project which involves readily-available materials in the classroom, on a field site, or at a community location. Use algebra to represent patterns and develop mathematical models; Use statistics to detect the significance of relationships; and Communicate project findings through formal papers, visual presentations, and interactions with peers or judges. STEM Research for Students, Volume 2 is: Student friendly! Each chapter is carefully sequenced and contains a variety of formative assessment tools. Key definitions are included in an appendix. Essential foundational knowledge from Volume 1 is clearly referenced. STEM encompassing! Students have multiple opportunities to make connections by applying information from the various chapters to original projects. Teacher enhanced! Each chapter contains learning objectives and assessment tools checklists or rubrics. Answers to the practice sets are available on a secure Kendall Hunt web site. Standards aligned! All chapters are aligned with the Next Generation Science Standards, Common Core Standards for Mathematics and Literacy in Science and Technical Subjects, and the International Standards for Technology in Education Standards for Students. Available in print and e-Book formats, STEM Research for Students, Volume 2, may be used: As a supplemental text in middle school, high school, and introductory college courses; As core text for research classes and STEM clubs where students are ready to engage in group or individual projects: For pre-service and in-service teachers of science, mathematics, career and technical courses, and gifted students; As a resource for all teachers involved with experiments, engineering designs, mathematical investigations, and competitive STEM projects. The companion volume, STEM Research for Students, Volume 1, is a resource for students to acquire or strengthen the foundational knowledge necessary to engage in an original project.

This volume, from an international authority on the subject, deals with the physical and instrumentation aspects of measurement science, the availability of major measurement tools, and how to use them. This book not only lays out basic concepts of electronic measurement systems, but also provides numerous examples and exercises for the student.
.Ideal for courses on instrumentation, control engineering and physics
.Numerous worked examples and student exercises

There have been many recent discussions of the replication crisis in psychology and other social sciences. This has been attributed, in part, to the fact that researchers hesitate to submit null results and journals fail to publish such results. In this book, Allan Franklin and Ronald Laymon analyze what constitutes a null result and present evidence, spanning a 400-year history, that null results play significant roles in physics. They begin with Galileo's experiments on falling bodies and conclude with tests of the weak equivalence principle in general relativity, the search for physics beyond the Standard Model, and the search for neutrinoless double beta decay, all in the 21st century. As these case studies make evident, null results have refuted theories, confirmed theories, provided evidence for potential new theories to explain, introduced new experimental techniques, corrected previous incorrect or misinterpreted results, and have been used to explore previously unstudied phenomena. What makes these many roles possible is the development of increasingly more accurate replications of a zero value result and the value of these replications for the effective treatment of systematic uncertainty. The book concludes with a brief analysis of certain fundamental differences between physics and social psychology in the role played by replication where these differences explain the absence of a replication crisis in physics.

This book provides a detailed overview of cancer theranostics applications of magnetic iron oxide nanoparticles. Their synthesis, characterization, multifunctionality, disease targeting, biodistribution, pharmacokinetics and toxicity are highlighted, along with current examples of clinical trials of magnetic nanoparticles in cancer theranostics, and their future scopes and challenges.

This is the fifth volume of "Advances in Sonochemistry" the first having been published in 1990. The definition of sonochemistry has developed to include not only the ways in which ultrsound has been harnessed to effect chemistry but also its uses in material processing. Subjects included range from chemical dosimetry to ultrasound in microbiology to ultrasound in the extraction of plant materials and in leather technology.

Though many separation processes are available for use in todays analytical laboratory, chromatographic methods are the most widely used. The applications of chromatography have grown explosively in the last four decades, owing to the development of new techniques and to the expanding need of scientists for better methods of separating complex mixtures. With its comprehensive, unified approach, this book will greatly assist the novice in need of a reference to chromatographic techniques, as well as the specialist suddenly faced with the need to switch from one technique to another.

This book is meant to be a companion volume for the ACS Symposium Series Book entitled Nuts and Bolts of Chemical Education Research. In the Nuts and Bolts book (edited by Diane M. Bunce and Renee Cole), readers were presented with information on how to conduct quality chemical education research. In the Myth book, exemplars of chemical education research are featured. In the cases where the chapter in the book is describing research that has already been published (typically in the Journal of Chemical Education), additional information is provided either in terms of research questions investigated that were not reported in the published article or background information on decisions made in the research that helped the investigation. The main focus of this type of discussion is to engage the reader in the reality of doing chemical education research including a discussion of the authors' motivation. It is expected that these two books could be used as textbooks for graduate chemical education courses showing how to do chemical education research and then providing examples of quality research.

Inspired by the opportunities and challenges presented by rapid advances in the fields of retrieval of chemical and other scientific information, several speakers presented at a symposium, The History of the Future of Chemical Information, on Aug. 20, 2012, at the 244th Meeting of the American Chemical Society in Philadelphia, PA. Storage and retrieval is of undeniable value to the conduct of chemical research. The participants believe that past practices in this field have not only contributed to the increasingly rapid evolution of the field but continue to do so, hence the somewhat unusual title. Even with archival access to several of the presentations, a number of the presenters felt that broader access to this information is of value. Thus, the presenters decided to create an ACS Symposium book based on the topic, with the conviction that it would be valuable to chemists of all disciplines. The past is a moving target depending on the vagaries of technology, economics, politics and how researchers and professionals choose to build on it. The aim of The History of the Future of Chemical Information is to critically examine trajectories in chemistry, information and communication as determined by the authors in the light of current and possible future practices of the chemical information profession. Along with some additional areas primarily related to present and future directions, this collection contains most of the topics covered in the meeting symposium. Most of the original authors agreed to write chapters for this book. Much of the historical and even current material is scattered throughout the literature so the authors strived to gather this information into a discrete source. Faced with the rapid evolution of such aspects as mobile access to information, cloud computing, and public resource production, this book will be not only of interest but provide valuable insight to this rapidly evolving field, both to practitioners within the field of chemical information and chemists everywhere whose need for current and accurate information on chemistry and related fields is increasingly important.

Students taught with inquiry-based methods have been shown to make significant progress in their ability to formulate hypotheses, make proper assumptions, design and execute investigations, understand variables, record data, and synthesize new knowledge. are taught with it. This text presents a series of experiments that are intended to serve as the solid basis for a first-year chemistry or physical sciences course, using an inquiry based approach. Each provides: 1)instructions for an experiment; 2) in-depth teachers notes and 3) a sample lab report.

Tools of Chemistry Education Research meets the current need for information on more in-depth resources for those interested in doing chemistry education research. Renowned chemists Diane M. Bunce and Renee S. Cole present this volume as a continuation of the dialogue started in their previous work, Nuts and Bolts of Chemical Education Research. With both volumes, new and experienced researchers will now have a place to start as they consider new research projects in chemistry education. Tools of Chemistry Education Research brings together a group of talented researchers to share their insights and expertise with the broader community. The volume features the contributions of both early career and more established chemistry education researchers, so as to promote the growth and expansion of chemistry education. Drawing on the expertise and insights of junior faculty and more experienced researchers, each author offers unique insights that promise to benefit other practitioners in chemistry education research.

The interactions of microbes with surfaces are important to many natural and engineered processes, affecting a wide range of applications from decontamination of surfaces or drinking water, prevention of microbial colonization of biomaterials, and bacterial processes in the environment. Therefore, there is great interest in understanding the fundamental behavior of microbes at surfaces. Topics are included that address interactions of cells with a number of surfaces for antifouling and microbial cell-based sensor applications; mechanistic studies of antimicrobial peptides and quorum sensing; exploration of experimental and theoretical models of a cell surface; cell surface display of peptides and enzymes as biofabrication techniques; the fate and transport of bacteria in the natural environment, as well as new experimental tools or modeling techniques to study interactions at the microbial surface.
While most of the papers are geared towards a specific application, they all contain fundamental information regarding bacterial behavior at interfaces that allows their contents to translate to other problems, as well. For example, many parallels are noted between the way bacteria interact with proteins-coated polymers on a catheter and bacterial-peptide interactions in a cellular detection assay. An overlying theme of all the manuscripts is that they represent studies of microbial interfaces using the most sophisticated experimental and modeling tools available, and many feature interdisciplinary approaches to tackling the given problems.

The book gives an overview of the current state-of-the-art concerning the activation and dissolution of cellulose in a broad variety of solvents. Research on this topic can lead to new pathways for the utilization of the most abundant terrestrial biomolecule and may therefore be the basis for new green strategies towards advanced materials. Leading scientists in the field show different conceptions for the solubilization of cellulose. The long history and groundbreaking developments in the field of polymer chemistry, which are related to this subject, have lead to timely alternatives to already established methods. In addition to discussing attempts for the optimization of known dissolving procedures, this book also details new solvent systems. New solvents include inorganic and organic salt melts (ionic liquids), new aqueous media, multi-component organic solvents and the dissolution under partial derivatization of the polysaccharide. The opportunities and the limitations of the solvents are demonstrated, with a particular emphasis on the stability of the solutions and a possible recycling of the solvent components.
This book illustrates that the new procedures for cellulose dissolution can lead to a huge number of unconventional superstructures of regenerated cellulose material, such as fibers and polymer layers with a thickness in the nanometer range or aerogels, i.e. regenerates with a highly porous character and a large surface. Moreover, cellulose blends can be generated via solutions. The book also contains chapters that show the amazing potential of solvents for defined modification reactions on the cellulose backbone. On one hand, it is possible to synthesize known cellulose derivatives with new substitution patterns both on the basis of the repeating unit and along the polymer chain. On the other hand, completely new derivatives are presented which are hardly accessible via heterogeneous reactions. Consequently, the book is intended to give a comprehensive overview of procedures for dissolution of cellulose. It is of interest for scientists new in the field but is also a timely summary of trends for experts who are looking for new approaches for problems related to cellulose shaping or chemical modification.