Lead (Pb) is an environmental pollutant, especially due to its anthropogenic activity.The present study aimed to investigate some of the toxic effects of lead exposure in quails and its amelioration through vitamin E supplementation. A total number of 420, day old chicks of Japanese quail were assigned seven dietary treatments.. Control group received only basal diet without any supplementation. Other groups received lead (Pb) alone or in different combinations with vitamin E. Lead (Pb) was administered in the feed at a dose level of 50, 75 and 100 mg/kg Pb. Vitamin E was administered in the feed at a dose level of 40mg/kg vit E .The body weight of each bird was weighed weekly and found significant changes in the weight of quails. Pathological lesions in lead (Pb) fed birds included enlarged, pale, friable liver and swollen kidneys.On the other hand, supplementation of vitamins E in lead intoxicated birds showed ameliorative effects in Lead (pb) toxicity. It was concluded that the vitamin E ameliorated the lead induced toxic effects in some of parameters studied