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As with other areas of biological research, the progress that has
been made over the past 25 years in the field of cell adhesion is
impressive. In the late 1970s, the searchfor specific cell surface
receptors for adhesion processes was initiated - ing mainly
biochemical and immunological approaches. Since then, theint-
duction of novel methods of cellular and molecular biology and
powerful te- niques for manipulatinggene expression in transgenic
and knock-out mice have greatlyadvanced the field. Not only dowe
now know the precise molecular structure of many of thecell
adhesion receptors that were postulated to exist in the early days,
but we have a clear picture of their function, and evidence of
their involvement in signal transduction. We have also found clues
to the role of cell adhesion in normal embryonal development and
adult physiology, and we have evidence that disturbance in cell
adhesion can cause disease. In this volume, our goal was to provide
an overview of the main topics of c- rent cell adhesion research,
including structural analyses of cell adhesion mo- cules and
studies of their functionalrole in vitroand in vivo. We have
focussed mainly on the four major families of cell-adhesion
receptors, i. e. the cadherins, the integrins, the Ig superfamily
and the selectin-based adhesion system. The chapters by Perez and
Nelson and Choi and Weis describethe structuralbasis of cadherin
function, focussing on the extracellular domain of cadherins and
thecytoplasmic tail interactions with catenins, respectively.
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