This Handbook illustrates that universities per se and higher education in general are essential to catalyze and action the transformative change needed for sustainability and delivery of the Sustainable Development Goals. Part One shows how sustainability can be adopted as a driver of change within higher education institutions (HEIs), as they react and respond to influencing factors outside the academy. Part Two examines how a university working with and for sustainability can influence, effect and amplify change beyond the institution, working with and through others. International contributors explore regional, national and international perspectives, presenting a variety of critically assessed accounts case studies that reflect different local and national contexts, institutional archetypes and academic missions. Frameworks of sustainability-led transformation are illustrated at the level of the institution (executive/administrative), organization, culture, place-based (anchor) and student in various countries including Aruba, Belgium, Brazil, Canada, Hong Kong, Japan, Lebanon, Nepal, New Zealand, Nigeria, South Africa, Spain, Uganda, United Kingdom and the United States of America. The book concludes with a manifesto for change and a call to action. It identifies that the sustainability journey of a HEI is influenced by context and place, with mission, leadership and strategy playing a vital role and change agency by students a key ingredient. Recognizing the patience and resolve to effect change, communication, dialogue and inclusion were central to community building and partnership.