In this adrenaline-fueled adventure, Optimus Prime and the Autobots take on their biggest challenge yet.

When a new threat capable of destroying the entire planet emerges, they must team up with a powerful faction known as the Maximals. With the fate of humanity hanging in the balance, Noah and Elena will do whatever it takes to help the Transformers as they engage in the ultimate battle to save Earth.

In this adrenaline-fueled adventure, Optimus Prime and the Autobots take on their biggest challenge yet.

When a new threat capable of destroying the entire planet emerges, they must team up with a powerful faction known as the Maximals. With the fate of humanity hanging in the balance, Noah and Elena will do whatever it takes to help the Transformers as they engage in the ultimate battle to save Earth.

The creator of “Hamilton” and the director of “Crazy Rich Asians” invite you to a cinematic event, where the streets are made of music and little dreams become big.

Lights up on Washington Heights. The scent of a cafecito caliente hangs in the air just outside of the 181st Street subway stop, where a kaleidoscope of dreams rallies this vibrant and tightknit community. At the intersection of it all is the likeable, magnetic bodega owner Usnavi (Anthony Ramos), who saves every penny from his daily grind as he hopes, imagines and sings about a better life.

“In the Heights” fuses Lin‐Manuel Miranda’s kinetic music and lyrics with director Jon M. Chu’s lively and authentic eye for storytelling to capture a world very much of its place, but universal in its experience.

Comprehensive Precision Medicine holistically integrates essential and interconnecting disciplines that contribute to the make-up of Precision Medicine as we know it today. Encompassing almost 90 contributions from eminent scholars and professionals, the book's contents are organized across 3 volumes and 7 major subject areas, each representing a key pillar driving the evolution and progression of healthcare delivery. Precision medicine approaches will transform the training and practice of all aspects of professional healthcare delivery, including medicine, nursing, pharmacy, psychology, rehabilitation, and social work. This will be a fundamental reference resource for students, post-graduate trainees, researchers, scientists and clinicians interested in precision medicine. Additionally, this resource will be of interest to regulators, policy makers, and public health practitioners across the globe.

The big bad wolf knows he rules the forest—but he likes to hear the others tell him so.

He marches through the woods, asking: “Tell me, who is the strongest?” Everyone, from Little Red Riding Hood to the Three Little Pigs to the Seven Dwarfs, agrees he is the strongest, the toughest, the terror of the woods. So when “a little toad of some sort” stands up to him, the wolf is furious—then quickly learns his lesson.

I Am So Strong is a great read-aloud for families and classrooms, and a delightful story for anyone who’s known an overconfident wolf.

“The wolf’s comeuppance is deeply satisfying; the only disappointment is that the book is over so soon. Better read it again.” Publishers Weekly

Mass Production of Beneficial Organisms: Invertebrates and Entomopathogens, Second Edition explores the latest advancements and technologies for large-scale rearing and manipulation of natural enemies while presenting ways of improving success rate, predictability of biological control procedures, and demonstrating their safe and effective use. Organized into three sections, Parasitoids and Predators, Pathogens, and Invertebrates for Other Applications, this second edition contains important new information on production technology of predatory mites and hymenopteran parasitoids for biological control, application of insects in the food industry and production methods of insects for feed and food, and production of bumble bees for pollination. Beneficial organisms include not only insect predators and parasitoids, but also mite predators, nematodes, fungi, bacteria and viruses. In the past two decades, tremendous advances have been achieved in developing technology for producing these organisms. Despite that and the globally growing research and interest in biological control and biotechnology applications, commercialization of these technologies is still in progress. This is an essential reference and teaching tool for researchers in developed and developing countries working to produce "natural enemies" in biological control and integrated pest management programs.

In this issue of Child and Adolescent Psychiatric Clinics, guest editors Drs. Scott Liebowitz, Serena Chang, and Natalia Ramos bring their considerable expertise to the topic of Transgender and Gender Diverse Children and Adolescents. Top experts in the field cover key topics such as complex psychiatric histories and gender diverse/transgender youth; neurodiversity and transgender/gender diverse youth: the co-occurrence; individual affirming care: psychological and social approaches to trans and gender diverse youth; psychosocial family treatments and navigating family dynamics; and more. Contains 16 relevant, practice-oriented topics including gender in youth; beyond sex and gender: dimensions across child and adolescent development; gender affirming medical treatments; perspectives: being a trans psychiatrist/provider; and more. Provides in-depth clinical reviews on transgender and gender diverse children and adolescents, offering actionable insights for clinical practice. Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.

Lately, tourists consider their mobile devices as essential accessories for the realization of their trip before, during, and after the visit. Such devices allow them to consult information about points of interest, services, or products in real time. Thus, mobile devices have come to be considered as tools to support decision making regarding the realization of trips. In the digital environment, tourists seek complementary information to consolidate knowledge about the destination, heritage, culture, customs, and traditions that make the visited place unique. Simultaneously, they transform tourist experiences into a memory associated with travel, contribute to the sustainability of local populations, reduce inequalities, and cooperate to improve the quality of life of all involved. ICT as Innovator Between Tourism and Culture differs from others on the same areas because it aims to place the emphasis on and increase the bridge of knowledge between information communications technology (ICT), tourism, and culture, considering ICT as the main driver that creates the development environment and enhances the tourist experience in general. In particular, it is linked to cultural heritage, making it a more sustainable and intelligent tourist destination, taking into account the well-being of the local population and visitors. Covering topics such as destination image, religious tourism, and innovation dynamics, this book is an essential resource for IT consultants, hotel managers, marketers, travel agencies, tour operators, tourism researchers, professors, students, practitioners within the tourism industry, and academicians.

Mineralizing Vesicles: From Biochemical and Biophysical Properties to Their Roles in Physiology and Disease presents the state-of-the art in the properties of mineralizing EVs and their potential clinical applications. The first chapter presents foundational biochemical and biological aspects of EVs. Next, the title coves the role of EVs in bone ossification and in cardiovascular and cartilage-related diseases. Considering the unique ability of this class of EVs to form apatite minerals assigned to their special biochemical machinery, three chapters of the book then focus on the enzymes catalysing the inorganic phosphate and calcium turn-over and the dynamic properties of the vesicles’ peripheral proteins. Chapters describe the role of inorganic phosphate and calcium ions and of autophagy on the biogenesis and function of mineralizing EVs. Recent studies show that the lumen of mineralizing EVs is partially filled with miRNA, and a chapter therefore considers research on the possible function of these vesicles as signalosomes. The final five chapters of the book describe practical aspects of working with mineralizing EVs, including their purification, proteomic and biophysical analyses, the use of biomimetic models and mineralizing EVs in regenerative medicine. This title presents, for the first time, a comprehensive account of mineralizing EVs and their potential clinical applications. It will be invaluable to researchers in the field.

Green bond issuance has surged in recent years in response to growing investor appetite and borrowers' needs as they embark on the sustainability transition. The EU leads the way, with over 40% of all sustainable bond issuances denominated in euro. The EU’s 'Regulation on European Green Bonds and optional disclosures for bonds marketed as environmentally sustainable and sustainability-linked bonds’ is the first comprehensive legislative text covering such issuance, and a cornerstone of EU’s Sustainable Finance strategy. This book explores in an interdisciplinary way the challenges and opportunities of green bonds and sustainable finance from a legal, regulatory and economic perspectives. First, it analyses green bonds as a new financial instrument in the context of the existing capital markets law. Second, it studies green bond impact on the market and on investor protection. Third, it assesses green bonds’ relevance for prudential supervision and central banking. The variety of viewpoints ensures a highly comprehensive analysis of green bonds’ impact in a European and global context.

This book provides scientific evidence, both theoretically and empirically, on the understudied field of women entrepreneurs across North Africa. It provides insights on the domain of women entrepreneurship, undertaking critical assessment of overall historical frameworks, ecosystems and future perspectives of the region.Women entrepreneurship is among the most important and unexploited sources of economic growth in the developing world. Yet, despite much progress in socioeconomic aspects such as health, life expectancy and education, the gender economic gap remains unchanged. More needs to be done to understand the underlying forces and factors in the region to challenge the current status quo.