The story of Depo-Provera joins the national struggle over the drug's FDA approval to the state legal issues raised by its contraceptive and criminal justice uses. Depo-Provera is known as an injectable hormonal birth control method, but few are familiar with its dark and complicated history. Depo-Provera was tested on women since the mid-1960s without their informed consent until it was FDA-approved in 1992, but never FDA-approved as chemical castration for male sex offenders. Contraceptive Risk is William Green's landmark study of Depo-Provera. Based on a fascinating combination of archival materials and interviews, the book is framed as three interconnected stories told by Judith Weisz, who chaired the FDA's Public Board of Inquiry on Depo-Provera, a scientific court; by Anne MacMurdo who brought a products liability suit against Upjohn, the drug's manufacturer, for the deleterious side effects she suffered from the drug's use; and by Roger Gauntlett, an Upjohn heir who, when he was convicted of sexual assault, refused to take a dose of his family's own medicine as a probation condition. Together these three stories of Depo-Provera's convoluted fifty year odyssey call for a paradigm shift in pharmaceutical drug development. Contraceptive Risk is a thoroughly researched and engrossing approach to the scientific, political and institutional forces involved in health law and policy, as well as the multifaceted politics of measuring risk.

'A brilliant book packed with powerful insights from the world's most successful investors' Tony Robbins 'A profound, eloquent, and much-needed call for a reassessment of how we build our portfolios and live our lives' Stig Brodersen 'A classic ... for generations, will define what it means to be a better investor and a better human' Guy Spier Billionaire investors. If we think of them, it's with a mixture of awe and suspicion. Clearly, they possess a kind of genius - the proverbial Midas Touch. But are the skills they possess transferable? And would we really want to be them? Do they have anything to teach us besides making money? In Richer, Wiser, Happier, award-winning journalist William Green has spent nearly twenty-five years interviewing these investing wizards and discovered that their talents expand well beyond the financial realm and into practical philosophy. Green ushers us into the lives of more than forty of the world's super-investors, visiting them in their offices, vacation homes, and even their places of worship - all to share what they have to teach us. Green brings together the thinking of some of the best investors, from Warren Buffett to Howard Marks to John Templeton, and provides gems of insight that will enrich you not only financially but also professionally and personally.

The dismantling of the Synthetic Fuels Corporation and the shelving of scores of synfuel plant proposals have triggered a need for a searching inquiry into the reasons why the initial promise of synfuels has not been realized. In this volume a distinguished group of political scientists, policy analysts, and energy planners apply the critical tools of economic, scientific, and political analysis in an attempt to illuminate why the dream of synthetic fuels development has ended, at least temporarily. The essays collected here grapple with a variety of problems surrounding the rise and demise of synthetic fuels development in the 1970s.

The essays in this volume explore the phenomenon of foreign industrial recruitment in terms of the experience of six mid-American states--Michigan, Ohio, Indiana, Illinois, Kentucky, and Tennessee--in attracting Japanese automobile assembly facilities. This experience and the choice of plant sites by Mazda, Honda, Fuji-Isuzu, Mitsubishi, Toyota, and Nissan was invariably determined by multi-state negotiations and escalating state government incentive packages. To understand this phenomenon and its consequences, the essays in this volume sketch its comparative historical, economic, and legal dimensions; examine the dynamics of Japanese automobile investment in terms of the six site-specific studies; and then place these industrial recruitment experiences within a wider framework of federal-state relations and the prospects for a national industrial policy. Part I illuminates the background to and the comparative setting for the mid-American competition for Japanese automobile plants in the era of international corporate flight. Part II carefully probes the dynamics of development in terms of six site-specific studies. Finally, Part III places these six state industrial recruitment experiences within the wider framework of federal-state relations. This book makes informative reading for anyone interested in the automobile industry, Japanese-American trade polices, and federal-state relations.

This volume is a collection of methodological developments and applications of simulation-based methods that were presented at a workshop at Louisiana State University in November, 2009. The first two papers are extensions of the GHK simulator: one reconsiders the computation of the probabilities in a discrete choice model while another example uses an adaptive version of sparse-grids integration (SGI) instead of simulation. Two studies are focused specifically on the methodology: the first compares the performance of the maximum-simulated likelihood (MSL) approach with a proposed composite marginal likelihood (CML) approach in multivariate ordered-response situations, while the second examines methods of testing for the presence of heterogeneity in the heterogeneity model. Further topics examined include: education savings accounts, parent contributions and education attainment; estimating the effect of exchange rate flexibility on financial account openness; estimating a fractional response model with a count endogenous regressor; and modelling and forecasting volatility in a bayesian approach.

BUGLER 'BILL' GREEN AND HIS OFFICER HARRY SMITH TELL THEIR STORIES OF FIGHTING AGAINST NAPOLEON'S ARMY IN SPAIN - The 95th, Wellington's famous green sharpshooter regiment was unusual in that it prompted several of its officers and men to write their memoirs of the war in the Peninsular against the French. These two very different men give us their experiences of campaigning and battles often played out within short steps of each other. This book contains two fascinating & engaging accounts of shared experiences and contrasting perspectives.

In the memorable words of Ragnar Frisch, econometrics is 'a unification of the theoretical-quantitative and the empirical-quantitative approach to economic problems'. Beginning to take shape in the 1930s and 1940s, econometrics is now recognized as a vital subdiscipline supported by a vast-and still rapidly growing-body of literature. Following the positive reception of The Rise of Econometrics (2013) (978-0-415-61678-2), Routledge now announces a new collection bringing together the best that has been published on the practical application and functional use of economic metrics and measurements. With a comprehensive introduction, newly written by the editor, which places the assembled materials in their historical and intellectual context, Applied Econometrics is an essential work of reference. This fully indexed collection will be particularly useful as an indispensable database allowing scattered and often fugitive material to be easily located. It will also be welcomed as a crucial tool permitting rapid access to less familiar-and sometimes overlooked-texts. For researchers and students, as well as economic policy-makers, it is a vital one-stop research and pedagogic resource.

The story of Depo-Provera joins the national struggle over the drug's FDA approval to the state legal issues raised by its contraceptive and criminal justice uses. Depo-Provera is known as an injectable hormonal birth control method, but few are familiar with its dark and complicated history. Depo-Provera was tested on women since the mid-1960s without their informed consent until it was FDA-approved in 1992, but never FDA-approved as chemical castration for male sex offenders. Contraceptive Risk is William Green's landmark study of Depo-Provera. Based on a fascinating combination of archival materials and interviews, the book is framed as three interconnected stories told by Judith Weisz, who chaired the FDA's Public Board of Inquiry on Depo-Provera, a scientific court; by Anne MacMurdo who brought a products liability suit against Upjohn, the drug's manufacturer, for the deleterious side effects she suffered from the drug's use; and by Roger Gauntlett, an Upjohn heir who, when he was convicted of sexual assault, refused to take a dose of his family's own medicine as a probation condition. Together these three stories of Depo-Provera's convoluted fifty year odyssey call for a paradigm shift in pharmaceutical drug development. Contraceptive Risk is a thoroughly researched and engrossing approach to the scientific, political and institutional forces involved in health law and policy, as well as the multifaceted politics of measuring risk.

For first-year graduate courses in Econometrics for Social Scientists. Bridging the gap between social science studies and econometric analysis Designed to bridge the gap between social science studies and field-econometrics, Econometric Analysis, 8th Edition, Global Edition, presents this ever-growing area at an accessible graduate level. The book first introduces students to basic techniques, a rich variety of models, and underlying theory that is easy to put into practice. It then presents students with a sufficient theoretical background to understand advanced techniques and to recognise new variants of established models. This focus, along with hundreds of worked numerical examples, ensures that students can apply the theory to real-world application and are prepared to be successful economists in the field.

For first-year graduate courses in Econometrics for Social Scientists. This title is a Pearson Global Edition. The Editorial team at Pearson has worked closely with educators around the world to include content which is especially relevant to students outside the United States. This text serves as a bridge between an introduction to the field of econometrics and the professional literature for graduate students in the social sciences, focusing on applied econometrics and theoretical concepts.