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Numerous studies have documented the importance of diastolic
dysfunction in heart disease. Now, providing cardiologists with the
most current information available on the subject, the editors have
pulled together contributions from an impressive array of top
researchers and compiled them into one comprehensive, carefully
edited source, Diastolic Relaxation of the Heart, Second Edition:
The Biology of Diastole in Health and Disease. This brand new
Second Edition, based on a recent meeting, includes such topics as:
molecular biology of relaxation; consequences of altered gene
expression; impaired relaxation in experimental models (ischemia
and hypoxia, and hypertrophy and failure); diastolic dysfunction in
the diseased human heart. Diastolic Relaxation of the Heart, Second
Edition: The Biology of Diastole in Health and Disease, the
successor to the editors' bestselling work on the same subject,
published in 1987 - belongs on the shelf of every practising
cardiologist. It will also be an invaluable addition to the library
of scientists researching the effects of diastole on heart
function.
viewed as rolling downhili from an uphill or This book represents
an edited compilation of the scientific presentations given at an
Interna- high-energy state. This transition results from tional
Symposium on the Physiology of Diastole the opening of membrane
pores that allow in Health and Disease, September 11 to 14, calcium
to rush into the cytosol, triggering 1986, in Cambridge,
Massachusetts. Numerous excitation-contraction coupling. If the
energy studies have documented the importance of available to
sarcoplasmic reticular and sarcolem- diastolic dysfunction in
clinical heart disease. In mal calcium pumps was insufficient to
remove recent years clinicians have become increasingly this
calcium from the cytosol and res tore the aware that many patients
with congestive heart 1O,OOO-fold calcium gradient, characteristic
of failure have completely normal myocardial con- the "resting"
myocyte, we would live for one tractile function. In these
patients, inotropic glorious systole and die in cardiac rigor. The
agents provide no clinical benefit and may in well-known phenomenon
of rigor mortis re- fact exacerbate clinical manifestations of
heart minds us that for skeletal muscles as weIl relaxation is the
high-energy state and per- failure. These patients, who may be
regarded as having diastolic heart failure, represent a major
manent contraction is the inevitable downhili therapeutic challenge
today. It has also become state for muscle that can no longer
produce increasingly apparent that a variety of patho- adenosine
triphosphate.
Numerous studies have documented the importance of diastolic
dysfunction in heart disease. Now, providing cardiologists with the
most current information available on the subject, the editors have
pulled together contributions from an impressive array of top
researchers and compiled them into one comprehensive, carefully
edited source, Diastolic Relaxation of the Heart, Second Edition:
The Biology of Diastole in Health and Disease. This brand new
Second Edition, based on a recent meeting, includes such topics as:
molecular biology of relaxation; consequences of altered gene
expression; impaired relaxation in experimental models (ischemia
and hypoxia, and hypertrophy and failure); diastolic dysfunction in
the diseased human heart. Diastolic Relaxation of the Heart, Second
Edition: The Biology of Diastole in Health and Disease, the
successor to the editors' bestselling work on the same subject,
published in 1987 - belongs on the shelf of every practising
cardiologist. It will also be an invaluable addition to the library
of scientists researching the effects of diastole on heart
function.
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