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Cardiac anatomy had already been a subject of and its control in
health and disease has been great interest for centuries when
Harvey de- published. Studies of hypertrophy, heart failure,
scribed the dynamic nature of blood flow, but ischemia, and
infarction have been vigorously the concept of defining ventricular
function was pursued in experimental animals and in human first
introduced with the measurement of a subjects, and as a result new
areas for study have emerged. These include the process of
hypertro- mare's blood pressure by Steven Hales in 1733. Amidst the
important contributions of a number phy as an adaptive mechanism,
the coronary vas- of European physiologists, the primal relation-
cular reserve in hypertrophy, the role of the ship between the
mechanical energy of the heart microvasculature in myocardial
failure, active and the length of a myocardial fiber was enun-
relaxation and other diastolic mechanisms that contribute to the
syndrome of congestive heart ciated by E. H. Starling in 1912; this
became known as the "law of the heart. " Perhaps the failure,
ventricular interaction and the role of the normal pericardium,
ischemic-stunned- first major refinement of this law was suggested
by Sarnoff and co-workers, who introduced the reperfused
myocardium, and vasoactive drugs in concept of homeometric
autoregulation to ex- the treatment of heart failure.
Sir Dominic Corrigan's classic monograph "On Permanent Patency of
the Mouth of the Aorta, or Inadequacy of the Aortic Valves" was
published in 1832. Descriptions of aortic regurgitation had
previously been published by others, but Corrigan's contribution
was so comprehensive that his name is still closely associated with
this disorder. He described the physical findings and the
underlying gross pathologic anatomy of aortic regurgitation. He
recognized that sudden death was not characteristic of aortic
regurgitation, as it was in aortic stenosis, and his therapeutic
approach was based on firm physiologic principles. In the past 150
years we have expanded Corrigan's work, and we have developed a
detailed appreciation of the natural history, pathophysiology,
diagnostic methods, and treatment of chronic aortic regurgitation.
Fifteen years ago, cardiac catheterization and angiography had
already achieved widespread application in the evaluation of aortic
regurgitation, but cardiac ultrasound, especially Doppler
echocardiography, was in its infancy, and the utility of
radionuclide ventriculography was not widely appreciated.
Sir Dominic Corrigan's classic monograph "On Permanent Patency of
the Mouth of the Aorta, or Inadequacy of the Aortic Valves" was
published in 1832. Descriptions of aortic regurgitation had
previously been published by others, but Corrigan's contribution
was so comprehensive that his name is still closely associated with
this disorder. He described the physical findings and the
underlying gross pathologic anatomy of aortic regurgitation. He
recognized that sudden death was not characteristic of aortic
regurgitation, as it was in aortic stenosis, and his therapeutic
approach was based on firm physiologic principles. In the past 150
years we have expanded Corrigan's work, and we have developed a
detailed appreciation of the natural history, pathophysiology,
diagnostic methods, and treatment of chronic aortic regurgitation.
Fifteen years ago, cardiac catheterization and angiography had
already achieved widespread application in the evaluation of aortic
regurgitation, but cardiac ultrasound, especially Doppler
echocardiography, was in its infancy, and the utility of
radionuclide ventriculography was not widely appreciated.
Cardiac anatomy had already been a subject of and its control in
health and disease has been great interest for centuries when
Harvey de- published. Studies of hypertrophy, heart failure,
scribed the dynamic nature of blood flow, but ischemia, and
infarction have been vigorously the concept of defining ventricular
function was pursued in experimental animals and in human first
introduced with the measurement of a subjects, and as a result new
areas for study have emerged. These include the process of
hypertro- mare's blood pressure by Steven Hales in 1733. Amidst the
important contributions of a number phy as an adaptive mechanism,
the coronary vas- of European physiologists, the primal relation-
cular reserve in hypertrophy, the role of the ship between the
mechanical energy of the heart microvasculature in myocardial
failure, active and the length of a myocardial fiber was enun-
relaxation and other diastolic mechanisms that contribute to the
syndrome of congestive heart ciated by E. H. Starling in 1912; this
became known as the "law of the heart. " Perhaps the failure,
ventricular interaction and the role of the normal pericardium,
ischemic-stunned- first major refinement of this law was suggested
by Sarnoff and co-workers, who introduced the reperfused
myocardium, and vasoactive drugs in concept of homeometric
autoregulation to ex- the treatment of heart failure.
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