F. Schweda and A. Kurtz: Regulation of Renin Release by Local and Systemic Factors M. Krauss and V. Haucke: Shaping Membranes for Endocytosis B.M. Jockusch and P.L. Graumann: The Long Journey: Actin on the Road to Pro- and Eukaryotic Cells B. Colsoul, R. Vennekens and B. Nilius: Transient Receptor Potential (TRP) Cation Channels in Pancreatic ss cells

F. Schweda and A. Kurtz: Regulation of Renin Release by Local and Systemic Factors M. Krauss and V. Haucke: Shaping Membranes for Endocytosis B.M. Jockusch and P.L. Graumann: The Long Journey: Actin on the Road to Pro- and Eukaryotic Cells B. Colsoul, R. Vennekens and B. Nilius: Transient Receptor Potential (TRP) Cation Channels in Pancreatic ss cells

Contents

Philip C. Sharpe, Rosemary S. Harrison, and David P. Fairlie: Amyloid Peptides and Proteins in Review. - Marilena Kampa, Artemissia-Phoebe Nifli, George Notas, Elias Castanas: Polyphenols and Cancer Cell Growth. - Michal Janitz: Assigning Functions to Genes The Main Challenge of the Post-Genomic Era. - Brigittte M. Jockusch, Kai Murk and Martin Rothkegel: The Profile of Profilins.

Contents

E.I. Christensen and R. Nielsen: Role of Megalin and Cubilin in Renal Physiology and Pathophysiology

G. Zifarelli and M. Pusch: CLC Chloride Channels and Transporters: A Biophysical and Physiological Perspective

S.F.J. van de Graaf, R.J.M. Bindels and J.G.J. Hoenderop: Physiology of Epithelial Ca2 and Mg2+ Transport

A piercing expose of American incompetence and corruption in Southeast Asia, The Ugly American captivated the nation when it was first published in 1958. The book introduces readers to an unlikely hero in the titular "ugly American"-and to the ignorant politicians and arrogant ambassadors who ignore his empathetic and commonsense advice. In linked stories and vignettes set in the fictional nation of Sarkhan, William J. Lederer and Eugene Burdick draw an incisive portrait of American foreign policy gone dangerously wrong-and how it might be fixed. Eerily relevant sixty years after its initial publication, The Ugly American reminds us that "today, as the battle for hearts and minds has shifted to the Middle East, we still can't speak Sarkhanese" (New York Times).

All the Ships at Sea Making Annapolis Was Easy Good old Barracks B is no more, and I guess Im its only mourner. It burned down in the winter of I 941 . Some Newporters claim that spontaneous combustion did the job. Alaybe so, but I wouldnt have blamed the captain of the head if he had struck the match. Nothing remains now but a heap of rubble. Perhaps there isnt even any rubble. I havent been to Newport for a year, but in 1930, when I arrived there as a hospital apprentice, Barracks B was the proudest building at the United States Naval Training Station. Though it had been built in 1904, it was still referred to as the New Barracks. Its SO new, said Coxswain Brown, that it aint even finished yet. Theres a couple of panes of glass missing. That head is cold enough to freeze a volcano all the way down to hell. All the Ships at Sea What Brown said about the crews head and wash- room being cold was true it was also dirty and smelly. These three qualities were brought to our attention the first thing every day. After leaving our warm hammocks we were lined up in the head, naked and shivering, to take our turns in the cold shower. I felt sorry enough for myself each morning, but I was sorrier for the guy who had to clean the place. Captain of the head was a tough billet. The job was given as unofficial punishment to men who were dirty or who didnt rise promptly at reveille. Yet the captain was an important personage because the lives of several hundred men revolved about the head. It was not only their bathroom but also their clubroom, curb market, and library. It was the only unsupervised spot in the barracks. We found it possible to sneak smokes there during working hours, and, despite thedirt and the draft, we could relax there a little. Fights were held in the head without interruption. The kind of literature not approved by the chaplain was read- and hidden-there. Small business was conducted within those cold gray walls. Here some sailors financed their Newport liberties by selling half-smoked cigarettes-snipes-four for a cent. The honest efforts of regimented souls to express themselves decorated the walls. Scribbled all over were such remarks as Chief Amorary has a shape like a beer bottle, or John LaPlant, the worlds greatest lover, blew his nose here. Making Annapolis Was Easy The place had a certain quality which the chief yeo- man called the sanctity of the john. But coziness was not part of that quality. Long streamers of twisted paper lay about, whispering in the multiple drafts. Soggy cigarette butts, shredded and brown, spotted the deck. The brass pipes had an overcoat of green mold. The vivid memory of this salon of discomfort dates back to a day in February, 1930, when I was summoned to the executive officers office. The sign on the door said COME IN. I obeyed. The exec, who was reading, looked at me over his glasses. Lederer Yes, sir. I have your application here for the Naval Academy Preparatory Class. Thank You, sir...

I am stunned by I, Giorghos. I was completely carried away by the beauty of the thought, the vigor of the writing and the absolute truth of the whole. I read far into the night until I had finished it and then lay awake thinking about it. I have rarely been so impressed or inspired by a book. It raised up my spirit, and the perfect line of the plot, from initial imperfection and degradation to what was exactly the right ending, gave me enormous satisfaction. What a wonderful journey that was, too, between beginning and end, with interesting development of character and philosophy, expressed in shining phrases, many of which I copied out because I couldn t bear to lose them. It s a triumph. Noreen Maxwell"

Many tens of thousands of copies of Sarkhan were in the bookstores on publication day. Suddenly it seemed to vanish. Mr. Lederer and the late Mr. Burdick were convinced that the book had been suppressed by agencies of the government, and certainly it contains much that might make such agencies unhappy. In a highly dramatic narrative, it tells of blundering by our intelligence community in Southeast Asia, of error and incompetence as well as heroics by Americans who understood Asia. Today, brought back to life after twelve years in limbo, ironically retitled The Deceptive American, and given a new, explanatory introduction, it is still relevant. The prescience of its message has been proved by events. The drama of its people and the drive of its narrative are undiminished."

This helpful, incisive analysis of marriage in America discusses the false assumptions of modern marriage and how to make a marriage work. It is imperative to realize, the authors argue, that the marital relationship is an interlocked system in itself, not a function of individual partners. They offer techniques for appraising one's own marriage, discuss the use of counselors and the dangers of unilateral therapy, and outline the major elements of a satisfactory marriage.

A five-week program for making bad relationships good and good relationships even better. The manual is in two parts. 1) Assessing and improving human relationships. 2) Identifying the often unsuspected physical ailments that contribute to a large proportion of unhappy relationships and that often can be cured or controlled nutritionally (see page 201).