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Genetic disease contributes to a major portion of our health care
costs. While most of the human genetic burden is transmitted from
generation to generation, environmental chemicals capable of
reacting with germ cell DNA could produce new mutations, resulting
in an even greater genetic liability for the next generation. The
potential impact of environmental mutagens on the health and
viability of other living things is important to consider as well.
Methods for Genetic Risk Assessment features contributions from
international experts to provide a comprehensive review of the
current status of genetic risk assessment. You'll learn about
various methods and strategies for when and how to conduct genetic
risk assessments on human populations. You will also learn about
the potential effects of environmental genotoxins on nonhuman
organisms. Topics considered include:
The study of the relationship between environmental pollution and
human health is in its infancy. The number of substances and
mixtures that have been identified in uncontrolled hazardous waste
sites or that have been in advertently released into the
environment is large and data on how thes~ substances are modified
as they interact with one another as they migrate through soil,
air, and water are limited. There are also limits on our un
derstanding of how these substances may be ingested, inhaled, or
absorbed by people. The complexity of possible interactions between
biological, chemical, and physical components in a given
environment makes it virtually impossible to evaluate the potential
for adverse biological effects ade quately in the laboratory.
Other, more comprehensive methods which provide realistic and
interpretable results must be used. Many scientists believe that
humans represent the ultimate sentinel species of a toxic exposure
re sUlting from environmental pollution, however such exposures may
also se verely impact environmental health. There exists a wide
variety of organ isms in the natural environment that could be used
to provide an early warning for potential human health effects as
well as to indicate adverse ecological effects. The issue of
effective utilization of sentinel species for environment al
monitoring is a rapidly developing area of research which has grown
in importance during the last decade.
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