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This book presents a systematic survey of different local
treatments in inflammatory joint diseases and their potential side
effects and complications. Both surgical therapies and
pharmaceutical strategies involving local or systemic application
of anti-inflammatory and immunomodulating drugs are addressed.
Special emphasis is placed on nuclear medicine therapy by
intra-articular instillation of beta radiation emitters, known as
radiosynoviorthesis or radiation synovectomy. Possible
complications, in particular radionecrosis, infection, and
thromboembolism, are described and available treatment strategies
are examined in detail. In addition, radiation safety
considerations are critically reviewed and relevant clinical
questions are discussed. While radiosynoviorthesis is an effective
and safe treatment if a proper indication is secured and if the
application is performed by an experienced nuclear medicine
physician, local complications can never be excluded with
certainty. This book will support physicians who are engaged in the
care and treatment of patients with inflammatory joint disease,
approximately 30,000 of whom undergo radiosynoviorthesis in Europe
each year.
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