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Drug Addiction: From Basic Research to Therapy provides a
comprehensive overview of physiological, biochemical, and genetic
pathways underlying drug addiction, and resultant efforts to
develop novel treatment strategies dealing with drug addiction and
other CNS disorders where the neurophysiological processes overlap,
such as treatment of pain. Based on the AAPS-NIDA Frontiers in
Science Symposium Drug Addiction: From Basic Research to Therapies,
this volume, representing focuses on the translation of fundamental
addiction research to a variety of treatments, bringing together
scientists with widely ranging expertise in synthetic and
computational chemistry, molecular biology, genetics, and
neuroscience with researchers in drug discovery and development,
drug targeting, and quantitative therapeutics."
Because progress in the field of transporters has been
extraordinary, this volume will focus on recent advances in our
understanding of the structure, function, physiology, and molecular
biology of membrane transporters. There will be an emphasis on
transporters as molecular targets for drug delivery and disposition
in the body.
Because progress in the field of transporters has been
extraordinary, this volume will focus on recent advances in our
understanding of the structure, function, physiology, and molecular
biology of membrane transporters. There will be an emphasis on
transporters as molecular targets for drug delivery and disposition
in the body.
Drug addiction is a chronic disorder characterized by compulsive
drug seeking and taking despite serious negative consequences.
Association studies have identified a number of candidate genes
harboring variants associated with susceptibility to addiction, but
the causative variants frequently remain unknown. A solution to the
challenge of identifying causative variants is the thorough
characterization of functional genetic polymorphisms and their
effects on regulation of candidate genes. I focused on candidate
genes for drug addiction (ARRB2, DRD2, and DRD3) and made some
novel and significant findings: The effects of two intronic SNPs in
the human dopamine receptor D2 (DRD2) gene, previously shown to
alter DRD2 alternative splicing, were confirmed in human brain
autopsy tissues obtained from a population of cocaine abusers and
controls. The same SNPs were significantly associated with cocaine
abuse. The results of this study contribute to our understanding of
the functional genetic variation in important candidate genes and
have the potential to improve the prevention and treatment of drug
addiction and other psychiatric disorders.
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