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The ribosome is a macromolecular machine that synthesizes proteins
with a high degree of speed and accuracy. Our present understanding
of its structure, function and dynamics is the result of six
decades of research. This book collects over 40 articles based on
the talks presented at the 2010 Ribosome Meeting, held in Orvieto,
Italy, covering all facets of the structure and function of the
ribosome. New high-resolution crystal structures of functional
ribosome complexes and cryo-EM structures of translating ribosomes
are presented, while partial reactions of translation are examined
in structural and mechanistic detail, featuring translocation as a
most dynamic process. Mechanisms of initiation, both in bacterial
and eukaryotic systems, translation termination, and novel details
of the functions of the respective factors are described. Structure
and interactions of the nascent peptide within, and emerging from,
the ribosomal peptide exit tunnel are addressed in several
articles. Structural and single-molecule studies reveal a picture
of the ribosome exhibiting the energy landscape of a processive
Brownian machine. The collection provides up-to-date reviews which
will serve as a source of essential information for years to come.
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