A comprehensive, integrated, and accessible textbook presenting core neuroscientific topics from a computational perspective, tracing a path from cells and circuits to behavior and cognition. This textbook presents a wide range of subjects in neuroscience from a computational perspective. It offers a comprehensive, integrated introduction to core topics, using computational tools to trace a path from neurons and circuits to behavior and cognition. Moreover, the chapters show how computational neuroscience-methods for modeling the causal interactions underlying neural systems-complements empirical research in advancing the understanding of brain and behavior. The chapters-all by leaders in the field, and carefully integrated by the editors-cover such subjects as action and motor control; neuroplasticity, neuromodulation, and reinforcement learning; vision; and language-the core of human cognition. The book can be used for advanced undergraduate or graduate level courses. It presents all necessary background in neuroscience beyond basic facts about neurons and synapses and general ideas about the structure and function of the human brain. Students should be familiar with differential equations and probability theory, and be able to pick up the basics of programming in MATLAB and/or Python. Slides, exercises, and other ancillary materials are freely available online, and many of the models described in the chapters are documented in the brain operation database, BODB (which is also described in a book chapter). Contributors Michael A. Arbib, Joseph Ayers, James Bednar, Andrej Bicanski, James J. Bonaiuto, Nicolas Brunel, Jean-Marie Cabelguen, Carmen Canavier, Angelo Cangelosi, Richard P. Cooper, Carlos R. Cortes, Nathaniel Daw, Paul Dean, Peter Ford Dominey, Pierre Enel, Jean-Marc Fellous, Stefano Fusi, Wulfram Gerstner, Frank Grasso, Jacqueline A. Griego, Ziad M. Hafed, Michael E. Hasselmo, Auke Ijspeert, Stephanie Jones, Daniel Kersten, Jeremie Knuesel, Owen Lewis, William W. Lytton, Tomaso Poggio, John Porrill, Tony J. Prescott, John Rinzel, Edmund Rolls, Jonathan Rubin, Nicolas Schweighofer, Mohamed A. Sherif, Malle A. Tagamets, Paul F. M. J. Verschure, Nathan Vierling-Claasen, Xiao-Jing Wang, Christopher Williams, Ransom Winder, Alan L. Yuille

What happens in our brain when we make a decision? What triggers a neuron to send out a signal? What is the neural code? This textbook for advanced undergraduate and beginning graduate students provides a thorough and up-to-date introduction to the fields of computational and theoretical neuroscience. It covers classical topics, including the Hodgkin-Huxley equations and Hopfield model, as well as modern developments in the field such as Generalized Linear Models and decision theory. Concepts are introduced using clear step-by-step explanations suitable for readers with only a basic knowledge of differential equations and probabilities, and are richly illustrated by figures and worked-out examples. End-of-chapter summaries and classroom-tested exercises make the book ideal for courses or for self-study. The authors also give pointers to the literature and an extensive bibliography, which will prove invaluable to readers interested in further study.

What happens in our brain when we make a decision? What triggers a neuron to send out a signal? What is the neural code? This textbook for advanced undergraduate and beginning graduate students provides a thorough and up-to-date introduction to the fields of computational and theoretical neuroscience. It covers classical topics, including the Hodgkin-Huxley equations and Hopfield model, as well as modern developments in the field such as Generalized Linear Models and decision theory. Concepts are introduced using clear step-by-step explanations suitable for readers with only a basic knowledge of differential equations and probabilities, and are richly illustrated by figures and worked-out examples. End-of-chapter summaries and classroom-tested exercises make the book ideal for courses or for self-study. The authors also give pointers to the literature and an extensive bibliography, which will prove invaluable to readers interested in further study.

This introduction to spiking neurons can be used in advanced-level courses in computational neuroscience, theoretical biology, neural modeling, biophysics, or neural networks. It focuses on phenomenological approaches rather than detailed models in order to provide the reader with a conceptual framework. The authors formulate the theoretical concepts clearly without many mathematical details. While the book contains standard material for courses in computational neuroscience, neural modeling, or neural networks, it also provides an entry to current research. No prior knowledge beyond undergraduate mathematics is required.