The first comprehensive book focusing on synthesis and applications of macrocyclic polyamines and their derivatives Macrocyclic polyamines are a class of widely used important compounds. This is the first book that systematically summarizes the synthesis and applications of macrocyclic polyamines and their analogues, including the properties and synthetic methods of macrocyclic polyamines, chemical nucleases based on macrocyclic polyamines, the derivatives of macrocyclic polyamines as nano-vector materials, macrocyclic polyamines derivatives for bio-imaging, chemical sensors based on macrocyclic polyamines, and other applications of macrocyclic polyamines. Macrocyclic Polyamines: Synthesis and Applications includes most of the studies involving macrocyclic polyamines and their derivatives, and may be used as a reference for the researchers in related fields. It offers in-depth coverage of cyclization modes; special procedures for tetraza macrocyclic compounds; diacids-diamines condensation; oxidative DNA cleaving by macrocyclic polyamines; lipids with cationic MPA headgroups; the derivatives of DOTA, DO3A, and PCTA; receptors for anions; sensors for bioactive molecules; macrocyclic polyamines for solvent extraction and membrane transport of amino acids and their derivatives, electrophoretic separation, and open-tubular CEC; and much more. ?The first book that systematically summarizes the chemistry of macrocyclic polyamines and their derivatives in terms of synthetic methods for their preparation, functionalization, and application in the main fields of chemical sensors, chemical nucleases, drug-delivery, bio-imaging and vector materials ?Provides a comprehensive reference for the researchers working on macrocyclic polyamines ?Offers train of thought in related research fields such as organic chemistry, coordination chemistry, analytical chemistry, supramolecular chemistry, biomaterials, etc. Macrocyclic Polyamines: Synthesis and Applications will not only provide a reference for the researchers working on macrocyclic polyamines, but also offer opportunities for researchers in related research fields to understand the benefits of these key compounds.

This comprehensive reference provides an in-depth discussion on state-of-the-art regulatory science in bioequivalence. In sixteen chapters, the volume explores a broad range of topics pertaining to bioequivalence, including its origin and principles, statistical considerations, food effect studies, conditions for waivers of bioequivalence studies, Biopharmaceutics Classification Systems, Biopharmaceutics Drug Disposition Classification System, bioequivalence modeling/simulation and best practices in bioanalysis. It also discusses bioequivalence studies with pharmacodynamic and clinical endpoints as well as bioequivalence approaches for highly variable drugs, narrow therapeutic index drugs, liposomes, locally acting gastrointestinal drug products, topical products and nasal and inhalation products.

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"FDA Bioequivalence Standards" is written by FDA regulatory scientists who develop regulatory policies and conduct regulatory assessment of bioequivalence. As such, both practical case studies and fundamental science are highlighted in these chapters. The book is a valuable resource for scientists who work in the pharmaceutical industry, regulatory agencies and academia as well as undergraduate and graduate students looking to expand their knowledge about bioequivalence standards.

A systematic exploration of both classic and contemporary algorithms in blind source separation with practical case studies The book presents an overview of Blind Source Separation, a relatively new signal processing method. Due to the multidisciplinary nature of the subject, the book has been written so as to appeal to an audience from very different backgrounds. Basic mathematical skills (e.g. on matrix algebra and foundations of probability theory) are essential in order to understand the algorithms, although the book is written in an introductory, accessible style. This book offers a general overview of the basics of Blind Source Separation, important solutions and algorithms, and in-depth coverage of applications in image feature extraction, remote sensing image fusion, mixed-pixel decomposition of SAR images, image object recognition fMRI medical image processing, geochemical and geophysical data mining, mineral resources prediction and geoanomalies information recognition. Firstly, the background and theory basics of blind source separation are introduced, which provides the foundation for the following work. Matrix operation, foundations of probability theory and information theory basics are included here. There follows the fundamental mathematical model and fairly new but relatively established blind source separation algorithms, such as Independent Component Analysis (ICA) and its improved algorithms (Fast ICA, Maximum Likelihood ICA, Overcomplete ICA, Kernel ICA, Flexible ICA, Non-negative ICA, Constrained ICA, Optimised ICA). The last part of the book considers the very recent algorithms in BSS e.g. Sparse Component Analysis (SCA) and Non-negative Matrix Factorization (NMF). Meanwhile, in-depth cases are presented for each algorithm in order to help the reader understand the algorithm and its application field. * A systematic exploration of both classic and contemporary algorithms in blind source separation with practical case studies * Presents new improved algorithms aimed at different applications, such as image feature extraction, remote sensing image fusion, mixed-pixel decomposition of SAR images, image object recognition, and MRI medical image processing * With applications in geochemical and geophysical data mining, mineral resources prediction and geoanomalies information recognition * Written by an expert team with accredited innovations in blind source separation and its applications in natural science * Accompanying website includes a software system providing codes for most of the algorithms mentioned in the book, enhancing the learning experience Essential reading for postgraduate students and researchers engaged in the area of signal processing, data mining, image processing and recognition, information, geosciences, life sciences.

This comprehensive reference provides an in-depth discussion on state-of-the-art regulatory science in bioequivalence. In sixteen chapters, the volume explores a broad range of topics pertaining to bioequivalence, including its origin and principles, statistical considerations, food effect studies, conditions for waivers of bioequivalence studies, Biopharmaceutics Classification Systems, Biopharmaceutics Drug Disposition Classification System, bioequivalence modeling/simulation and best practices in bioanalysis. It also discusses bioequivalence studies with pharmacodynamic and clinical endpoints as well as bioequivalence approaches for highly variable drugs, narrow therapeutic index drugs, liposomes, locally acting gastrointestinal drug products, topical products and nasal and inhalation products. FDA Bioequivalence Standards is written by FDA regulatory scientists who develop regulatory policies and conduct regulatory assessment of bioequivalence. As such, both practical case studies and fundamental science are highlighted in these chapters. The book is a valuable resource for scientists who work in the pharmaceutical industry, regulatory agencies and academia as well as undergraduate and graduate students looking to expand their knowledge about bioequivalence standards.