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The first comprehensive book focusing on synthesis and applications
of macrocyclic polyamines and their derivatives Macrocyclic
polyamines are a class of widely used important compounds. This is
the first book that systematically summarizes the synthesis and
applications of macrocyclic polyamines and their analogues,
including the properties and synthetic methods of macrocyclic
polyamines, chemical nucleases based on macrocyclic polyamines, the
derivatives of macrocyclic polyamines as nano-vector materials,
macrocyclic polyamines derivatives for bio-imaging, chemical
sensors based on macrocyclic polyamines, and other applications of
macrocyclic polyamines. Macrocyclic Polyamines: Synthesis and
Applications includes most of the studies involving macrocyclic
polyamines and their derivatives, and may be used as a reference
for the researchers in related fields. It offers in-depth coverage
of cyclization modes; special procedures for tetraza macrocyclic
compounds; diacids-diamines condensation; oxidative DNA cleaving by
macrocyclic polyamines; lipids with cationic MPA headgroups; the
derivatives of DOTA, DO3A, and PCTA; receptors for anions; sensors
for bioactive molecules; macrocyclic polyamines for solvent
extraction and membrane transport of amino acids and their
derivatives, electrophoretic separation, and open-tubular CEC; and
much more. ?The first book that systematically summarizes the
chemistry of macrocyclic polyamines and their derivatives in terms
of synthetic methods for their preparation, functionalization, and
application in the main fields of chemical sensors, chemical
nucleases, drug-delivery, bio-imaging and vector materials
?Provides a comprehensive reference for the researchers working on
macrocyclic polyamines ?Offers train of thought in related research
fields such as organic chemistry, coordination chemistry,
analytical chemistry, supramolecular chemistry, biomaterials, etc.
Macrocyclic Polyamines: Synthesis and Applications will not only
provide a reference for the researchers working on macrocyclic
polyamines, but also offer opportunities for researchers in related
research fields to understand the benefits of these key compounds.
This comprehensive reference provides an in-depth discussion on
state-of-the-art regulatory science in bioequivalence. In sixteen
chapters, the volume explores a broad range of topics pertaining to
bioequivalence, including its origin and principles, statistical
considerations, food effect studies, conditions for waivers of
bioequivalence studies, Biopharmaceutics Classification Systems,
Biopharmaceutics Drug Disposition Classification System,
bioequivalence modeling/simulation and best practices in
bioanalysis. It also discusses bioequivalence studies with
pharmacodynamic and clinical endpoints as well as bioequivalence
approaches for highly variable drugs, narrow therapeutic index
drugs, liposomes, locally acting gastrointestinal drug products,
topical products and nasal and inhalation products. FDA
Bioequivalence Standards is written by FDA regulatory scientists
who develop regulatory policies and conduct regulatory assessment
of bioequivalence. As such, both practical case studies and
fundamental science are highlighted in these chapters. The book is
a valuable resource for scientists who work in the pharmaceutical
industry, regulatory agencies and academia as well as undergraduate
and graduate students looking to expand their knowledge about
bioequivalence standards.
This comprehensive reference provides an in-depth discussion on
state-of-the-art regulatory science in bioequivalence. In sixteen
chapters, the volume explores a broad range of topics pertaining to
bioequivalence, including its origin and principles, statistical
considerations, food effect studies, conditions for waivers of
bioequivalence studies, Biopharmaceutics Classification Systems,
Biopharmaceutics Drug Disposition Classification System,
bioequivalence modeling/simulation and best practices in
bioanalysis. It also discusses bioequivalence studies with
pharmacodynamic and clinical endpoints as well as bioequivalence
approaches for highly variable drugs, narrow therapeutic index
drugs, liposomes, locally acting gastrointestinal drug products,
topical products and nasal and inhalation products.
""
"FDA Bioequivalence Standards" is written by FDA regulatory
scientists who develop regulatory policies and conduct regulatory
assessment of bioequivalence. As such, both practical case studies
and fundamental science are highlighted in these chapters. The book
is a valuable resource for scientists who work in the
pharmaceutical industry, regulatory agencies and academia as well
as undergraduate and graduate students looking to expand their
knowledge about bioequivalence standards.
A systematic exploration of both classic and contemporary
algorithms in blind source separation with practical case studies
The book presents an overview of Blind Source Separation, a
relatively new signal processing method. Due to the
multidisciplinary nature of the subject, the book has been written
so as to appeal to an audience from very different backgrounds.
Basic mathematical skills (e.g. on matrix algebra and foundations
of probability theory) are essential in order to understand the
algorithms, although the book is written in an introductory,
accessible style. This book offers a general overview of the basics
of Blind Source Separation, important solutions and algorithms, and
in-depth coverage of applications in image feature extraction,
remote sensing image fusion, mixed-pixel decomposition of SAR
images, image object recognition fMRI medical image processing,
geochemical and geophysical data mining, mineral resources
prediction and geoanomalies information recognition. Firstly, the
background and theory basics of blind source separation are
introduced, which provides the foundation for the following work.
Matrix operation, foundations of probability theory and information
theory basics are included here. There follows the fundamental
mathematical model and fairly new but relatively established blind
source separation algorithms, such as Independent Component
Analysis (ICA) and its improved algorithms (Fast ICA, Maximum
Likelihood ICA, Overcomplete ICA, Kernel ICA, Flexible ICA,
Non-negative ICA, Constrained ICA, Optimised ICA). The last part of
the book considers the very recent algorithms in BSS e.g. Sparse
Component Analysis (SCA) and Non-negative Matrix Factorization
(NMF). Meanwhile, in-depth cases are presented for each algorithm
in order to help the reader understand the algorithm and its
application field. * A systematic exploration of both classic and
contemporary algorithms in blind source separation with practical
case studies * Presents new improved algorithms aimed at different
applications, such as image feature extraction, remote sensing
image fusion, mixed-pixel decomposition of SAR images, image object
recognition, and MRI medical image processing * With applications
in geochemical and geophysical data mining, mineral resources
prediction and geoanomalies information recognition * Written by an
expert team with accredited innovations in blind source separation
and its applications in natural science * Accompanying website
includes a software system providing codes for most of the
algorithms mentioned in the book, enhancing the learning experience
Essential reading for postgraduate students and researchers engaged
in the area of signal processing, data mining, image processing and
recognition, information, geosciences, life sciences.
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