This volume constitutes the refereed proceedings of the 25th European Conference on Systems, Software and Services Process Improvement, EuroSPI conference, held in Bilbao, Spain, in September 2018. The 56 revised full papers presented were carefully reviewed and selected from 95 submissions. They are organized in topical sections on SPI context and agility, SPI and safety testing, SPI and management issues, SPI and assessment, SPI and safety critical, gamifySPI, SPI in industry 4.0, best practices in implementing traceability, good and bad practices in improvement, safety and security, experiences with agile and lean, standards and assessment models,team skills and diversity strategies, SPI in medical device industry, empowering the future infrastructure.

This volume constitutes the refereed proceedings of the four workshops held at the 30th International Conference on Database and Expert Systems Applications, DEXA 2019, held in Linz, Austria, in August 2019: The 10th International Workshop on Biological Knowledge Discovery from Data, BIOKDD 2019, the 3rd International Workshop on Cyber-Security and Functional Safety in Cyber-Physical Systems, IWCFS 2019, the 1st International Workshop on Machine Learning and Knowledge Graphs, MLKgraphs2019, and the 16th International Workshop on Technologies for Information Retrieval, TIR 2019. The 26 selected papers discuss a range of topics including: knowledge discovery, biological data, cyber security, cyber-physical system, machine learning, knowledge graphs, information retriever, data base, and artificial intelligent.