This book provides a detailed overview of B-cell directed therapies in patients with rheumatic and systemic autoimmune diseases, including rheumatoid arthritis, systemic lupus erythematosus, Sjoegren syndrome, ANCA-associated vasculitis and cryoglobulinemia. Organ-specific autoimmune diseases are discussed with respect to the use of B-cell directed therapies in neurological autoimmune diseases and autoimmune cytopenias. Situations in which B-cell targeted therapy may be indicated are identified, thereby offering comprehensive support for therapeutic decisions on the basis of the latest published evidence. The book also offers a valuable reference tool for rheumatologists, internists, nephrologists, immunologists, and all specialists involved in the multidisciplinary care of patients with rheumatic and systemic autoimmune diseases.

While our knowledge about cancer is proliferating rapidly, our principles of cancer medicine for individual patients and for populations are evolving only gradually. Our fundamental understanding of cancer causes and deve lopment is incomplete, and our treatments are nonspecific and less often curative than we would like. Nevertheless, worldwide, our major challenge remains to apply to our populations all that we know about cancer. To meet this challenge, doctors everywhere need a broad view and under standing of cancer causes and control. This book is intended for doctors-in-training and clinical medical practi tioners; it provides principles across the breadth of cancer medicine. The editors and authors believe that it is possible to reduce the exposition of current knowledge to the compact 40 chapters and 600 pages presented here without losing the comprehensiveness, richness, and pragmatic detail that doctors need. This compilation presumes knowledge of the basic sciences, particularly genetics, pathology, anatomy, and physiology. We have tried to balance scientific exposition with practical material in preven tion, early detection, and palliative care, which are the major areas of pub lic health medicine where greater attention is needed worldwide. While this book is based, in part, on material prepared for previous edi tions, each chapter has been newly written and edited by the authors and editorial staff for this edition."

Human Papillomavirus: Proving and Using a Viral Cause for Cancer presents a steady and massive accumulation of evidence about the role of HPV and prevention of HPV-induced cancer, along with the role and personal commitment of many scientists of different backgrounds in establishing global relevance. This exercise involved years of personal commitment to proving or disproving an idea that aroused initial skepticism, and that still has difficult implications for some. It remains one of the big successes of medicine that exploited both established medical science dating back to the nineteenth century and new molecular genetic science during a time of transition in medicine.