This book presents the latest trends in scientific methods and enabling technologies to advance e-business. It consists of selected high-quality papers from the 16th International Conference on E-Business Engineering (ICEBE 2019), held in Shanghai, China, on 11-13 October 2019. ICEBE is a leading international forum for researchers, engineers, and business specialists to exchange cutting-edge ideas, findings, and experiences in the field of e-business. The book covers a range of topics, including agents for e-business, big data for e-business, Internet of Things, mobile and autonomous computing, security/privacy/trust, service-oriented and cloud computing, software engineering, blockchain, and industry applications.