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Validamycin and Its Derivatives: Discovery, Chemical Synthesis and
Biological Activity presents, for the first time, a complete review
of the underlying chemistry, synthesis, behavior and application of
these compounds. Beginning with an introduction to validamycin, the
book then outlines the key elements of its discovery and
production, including details of its structures, isolation,
analysis, and issues relating to its large scale production.
Biological activities are then explored in more detail, followed by
details of biosynthesis. Further to this, the chemical synthesis of
validamycin and its intermediates, including valienamine,
validamine, valiolamine, and validoxylamines is reviewed, before
preparation of these derivatives and their biological activities
are explored. Finally, the book concludes with a discussion of the
economic aspects of working with validamycin and its potential in
future applications and trends. With its detailed chemical coverage
from a team of expert authors, this detailed guide can be applied
to the large-scale industrial production of antibiotics and the
adaptation of bioactive agents, from agricultural, to novel
pharmaceutical applications.
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