The book provides an in-depth and comprehensive overview of the essential role of non-coding RNAs (ncRNAs) in bone formation. In combination with researches from multiple scholars in this field, the book reviews the mechanisms of ncRNA-related bone diseases, as well as the potential applications of RNA synthesis technology in bone disorder treatments. This volume covers the following topics: 1) basic introduction of non-coding RNA and bone development, how 2) microRNAs and 3) long noncoding RNAs (LncRNAs) regulate bone formation, 4) how ncRNAs and the corresponding pathways participate in bone metabolism diseases, 5) RNA synthesis technology and the possible RNA therapies in bone disease. Researchers and students in the fields of human genetics, human physiology, developmental biology and biomedical engineering, as well as professionals and scientists in Orthopedics, will particularly find this book helpful.

The book provides an in-depth and comprehensive overview of the essential role of non-coding RNAs (ncRNAs) in bone formation. In combination with researches from multiple scholars in this field, the book reviews the mechanisms of ncRNA-related bone diseases, as well as the potential applications of RNA synthesis technology in bone disorder treatments. This volume covers the following topics: 1) basic introduction of non-coding RNA and bone development, how 2) microRNAs and 3) long noncoding RNAs (LncRNAs) regulate bone formation, 4) how ncRNAs and the corresponding pathways participate in bone metabolism diseases, 5) RNA synthesis technology and the possible RNA therapies in bone disease. Researchers and students in the fields of human genetics, human physiology, developmental biology and biomedical engineering, as well as professionals and scientists in Orthopedics, will particularly find this book helpful.

This book summarizes the latest advances in understanding chloride ingress and steel corrosion in concrete under service loads. Unlike the existing literature, it focuses specifically on the effect of service loads on chloride-induced durability issues in reinforced concrete structures. It discusses how service loads affect the moisture and chloride penetration rate, corrosion kinetics and rust distribution, as well as the structural performance of concrete components (e.g. beams and columns) in a systematic and hierarchical way. Given its scope, the book is chiefly intended for researchers and industry practitioners in structural engineering, particularly those whose work involves the durability design of concrete structures.

This book summarizes the latest advances in understanding chloride ingress and steel corrosion in concrete under service loads. Unlike the existing literature, it focuses specifically on the effect of service loads on chloride-induced durability issues in reinforced concrete structures. It discusses how service loads affect the moisture and chloride penetration rate, corrosion kinetics and rust distribution, as well as the structural performance of concrete components (e.g. beams and columns) in a systematic and hierarchical way. Given its scope, the book is chiefly intended for researchers and industry practitioners in structural engineering, particularly those whose work involves the durability design of concrete structures.

This book investigates the problem of reducing operating cost for a video streaming content delivery network (CDN), including both the CDN's energy and traffic costs. It first introduces the key issues and design choices of representative real-world CDNs, and discusses the energy saving techniques for data centers and CDNs. Then, based on a measurement study on a large video streaming CDN, it reveals an inherent conflict between improving a video streaming CDN's energy efficiency for energy saving, and maintaining the CDN's ISP-friendly server selection policy. Further, it discusses a cost-aware capacity provisioning algorithm that not only allows the service capacity of a CDN's server clusters in numerous ISPs to be dynamically planned, but also means that the overall operating cost, including both the energy consumptions and the cross-ISP traffics, can be further optimized. In addition it uses the workload derived from real-world measurement and also implements real values of the actual power and bandwidth prices to evaluate the capacity provisioning algorithm, showing that it can significantly reduce the overall operating cost of a video streaming CDN, and effectively avoid frequent server switches. Lastly, the book outlines a number of potential research directions regarding cost-aware content delivery. The measurement, analysis, and optimization methodologies and results presented in this book are of particular interest to researchers in the Internet and networking area.