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Boron-based drugs have attracted broad interest from both academia
and industry. This book describes advanced boron-based drugs, new
applications and related pharmacology. Authoritative yet
accessible, it begins with an introduction to general boron
chemistry, before detailing FDA-approved boron-containing drugs,
boron agents for neutron capture therapy and clinical reports for
boron neutron capture therapy. Designed for academic and industrial
scientists, this is a valuable resource that brings together in one
comprehensive volume cutting-edge information on the current state
of boron-based medicinal chemistry.
The book focuses on two concurrent experimental therapies in cancer
treatment known as boron neutron capture therapy (BNCT) and
gadolinium neutron capture therapy (GdNCT) using a variety of
boron- and gadolinium-based compounds. Some of the gadolinium
compounds serve the dual purpose as being MRI contrast agents and
GdNCT agents. The book describes why BNCT & GdNCT were not at
the forefront of the clinical trials during the past seven to eight
decades since the discovery of neutrons by John Chadwick in 1932
and how the latest development in the synthesis of target boron-
and gadolinium-based drugs have turned the area to be the hottest
one and worthy of further investigation with the new clinical
trials in the USA and elsewhere.
Fundamentals and Applications of Boron Chemistry highlights its
impressive potential for current and future developments across a
range of fields, providing foundational information on boron
chemistry and systematically summarizing applications of boron in
energy, medicinal chemistry, and materials chemistry. Beginning
with an introduction to boron chemistry which outlines the boron
element and its physical and chemical properties, this book goes on
to discuss advances in boron coordination chemistry, before delving
deeper into key fields of application. The latest developments in
boron-based catalysts in organic reactions are reviewed, followed
by novel emerging boron-containing materials and their potential
applications in areas such as hydrogen storage, and boron materials
with special optical activity. Finally, advance boron-based drugs
and therapies are explored. This book fills the current market gap,
systematically summarizing developments and applications of boron
in energy, medicinal chemistry, and materials chemistry in a
single, accessible volume. It is a valuable reference for chemists,
students, and researchers in relative areas.
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