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Cardiovascular disease is the major cause of mortality and
morbidity in the Western Hemisphere. While significant progress has
been made in treating a major sub-category of cardiac disease,
arrhythmias, significant unmet needs remain. In particular, every
day, thousands of patients die because of arrhythmias in the US
alone, and atrial fibrillation is the most common arrhythmia
affecting millions of patients in the US alone at a given time.
Therefore, there is a public need to continue to develop new and
better therapies for arrhythmias. Accordingly, an ever increasing
number of biomedical, pharmaceutical, and medical personnel is
interested in studying various aspects of arrhythmias at a basic,
translational, and applied level, both in industry (ie Biotech,
Pharmaceutical and device), and in academia. Not only has our
overall understanding of molecular bases of disease dramatically
increased, but so has the number of available and emerging
molecular, pharmacological or device treatment based therapies.
This practical, state-of-the art handbook will summarize and review
key research methods and protocols, their advantages and pitfalls,
with a focus on practical implementation, and collaborative
cross-functional research. The volume will include visual and
easy-to-use graphics, bulleted summaries, boxed summary paragraphs,
links to reference websites, equipment manufacturers where
appropriate, photographs of typical experimental setups and so
forth, to keep this book very focused on practical methods and
implementation, and yet, provide enough theory that the principles
are clearly understood and can be easily applied.
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