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Biomaterials for Surgical Operation offers a review of the latest
advances made in developing bioabsorbable devices for surgical
operations which include surgical adhesives (sealants), barriers
for the prevention of tissue adhesion, polymers for fractured bone
fixation, growth factors for the promotion of wound healing, and
sutures. Over the years, many descriptions of biomaterials have
appeared in academic journals and books, but most of them have been
devoted to limited clinical areas. This is in marked contrast with
this volume which covers a wide range of bioabsorbable devices used
in surgery from a practical point of view. The currently applied
polymeric devices are critical in surgery, but all involve serious
problems due to their poor performance. For instance, fibrin glue,
the most widely used surgical sealant, can produce only a weak gel
with low adhesive strength to tissues, accentuating the limited
effectiveness of current treatment options. Likewise, the currently
available barrier membranes cannot fully prevent tissue adhesion at
the acceptable level and are, moreover, not easy to handle with
endoscopes due to their poor mechanical properties. Biomaterials
for Surgical Operation is aimed at those who are interested in
expanding their knowledge of how the problems associated with the
currently used devices for surgical operation can be solved. It
primarily focuses on the absorbable biomaterials which are the main
components of these medical devices.
Biomaterials for Surgical Operation offers a review of the latest
advances made in developing bioabsorbable devices for surgical
operations which include surgical adhesives (sealants), barriers
for the prevention of tissue adhesion, polymers for fractured bone
fixation, growth factors for the promotion of wound healing, and
sutures. Over the years, many descriptions of biomaterials have
appeared in academic journals and books, but most of them have been
devoted to limited clinical areas. This is in marked contrast with
this volume which covers a wide range of bioabsorbable devices used
in surgery from a practical point of view. The currently applied
polymeric devices are critical in surgery, but all involve serious
problems due to their poor performance. For instance, fibrin glue,
the most widely used surgical sealant, can produce only a weak gel
with low adhesive strength to tissues, accentuating the limited
effectiveness of current treatment options. Likewise, the currently
available barrier membranes cannot fully prevent tissue adhesion at
the acceptable level and are, moreover, not easy to handle with
endoscopes due to their poor mechanical properties. Biomaterials
for Surgical Operation is aimed at those who are interested in
expanding their knowledge of how the problems associated with the
currently used devices for surgical operation can be solved. It
primarily focuses on the absorbable biomaterials which are the main
components of these medical devices.
Tissue engineering is an emerging interdisciplinary field,
occupying a major position in the regenerative medicine that aims
at restoring lost or damaged tissues and organs with use of cells.
Regenerative medicine includes cellular therapy and tissue
engineering. In general, the former treats patients by cell
infusion alone, while tissue engineering needs biomaterials and
growth factors in addition to cells. Biomaterials function in
tissue engineering as the scaffold or template for cells to
proliferate, differentiate, and produce matrices. This book focuses
on the fundamentals (biomaterials, scaffolds, cell cultures,
bioreactors, animal models etc.), recent animal and human trials,
and future prospects regarding tissue engineering.
Almost twenty years have passed since the advent of the tissue
engineering, whicht uses cells, scaffolds, and growth factors for
regeneration of neotissues. The number of investigations on tissue
engineering is still increasing tremendously. Nevertheless, it
seems likely that the number of reports describing clinical trials
of tissue engineering will remain very limited. Even the studies
that apply tissue engineering research to large animals have not
been performed yet on a large scale. The major objective of this
book is to address this question from a science and technology
point of view, and to describe the principles of basic technologies
that have currently been developed by numerous research
groups.
* Helps reader understand the key issues required for promotion of
clinical trials in tissue engineering
* Covers in full the issues related to tissue engineering
* Looking at current technologies in the field
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