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Malignant neoplasms occurring in the biliary tract and pancreas
remain a therap- tic challenge. The mechanism of carcinogenesis as
well as the growth and spread of these tumors is still poorly
understood, making the development of rational tre- ment strategies
difficult. In order to improve the clinical results achieved by
sur- cal or other medical treatment of such malignant tumors, the
establishment of an experimental animal model is critical. For this
purpose, attempts were made to induce carcinoma experimentally in
the biliary tree and finally an animal model using the hamster was
established in 1994 at our laboratory. Because the tumor in this
model mimicked the characteristics of human tumors, a series of
experimental investigations were conducted to clarify the
pathological characteristics of biliary carcinoma, the genetic
alterations during biliary carcinogenesis, and the relationship
between biliary inflammation and c- cinogenesis. The
chemopreventive effects on the occurrence of biliary carcinoma were
also successfully examined. In addition, in vitro studies led to
the establi- ment of transplantable biliary cancer cell lines and
biliary epithelial cell lines by utilizing the hamster model. This
monograph represents the collective efforts in hepato-biliary and
pancreatic disease research over the past 20 years. I hope that
this monograph will be a source of useful knowledge for basic
researchers as well as for clinicians involved in the care of
patients with hepato-biliary and pancreatic neoplasms. Takashi
Kanematsu, M.D., Ph.D.
Malignant neoplasms occurring in the biliary tract and pancreas
remain a therap- tic challenge. The mechanism of carcinogenesis as
well as the growth and spread of these tumors is still poorly
understood, making the development of rational tre- ment strategies
difficult. In order to improve the clinical results achieved by
sur- cal or other medical treatment of such malignant tumors, the
establishment of an experimental animal model is critical. For this
purpose, attempts were made to induce carcinoma experimentally in
the biliary tree and finally an animal model using the hamster was
established in 1994 at our laboratory. Because the tumor in this
model mimicked the characteristics of human tumors, a series of
experimental investigations were conducted to clarify the
pathological characteristics of biliary carcinoma, the genetic
alterations during biliary carcinogenesis, and the relationship
between biliary inflammation and c- cinogenesis. The
chemopreventive effects on the occurrence of biliary carcinoma were
also successfully examined. In addition, in vitro studies led to
the establi- ment of transplantable biliary cancer cell lines and
biliary epithelial cell lines by utilizing the hamster model. This
monograph represents the collective efforts in hepato-biliary and
pancreatic disease research over the past 20 years. I hope that
this monograph will be a source of useful knowledge for basic
researchers as well as for clinicians involved in the care of
patients with hepato-biliary and pancreatic neoplasms. Takashi
Kanematsu, M.D., Ph.D.
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